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Protein

Potassium channel subfamily K member

Gene

Kcnk15

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • potassium ion leak channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelUniRule annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K memberUniRule annotation
Gene namesi
Name:Kcnk15Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2675209 Kcnk15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei99 – 118HelicalSequence analysisAdd BLAST20
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei178 – 200HelicalSequence analysisAdd BLAST23
Transmembranei206 – 227HelicalSequence analysisAdd BLAST22
Transmembranei239 – 267HelicalSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000035238 Expressed in 20 organ(s), highest expression level in brain

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048326

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 151Ion_trans_2InterPro annotationAdd BLAST57
Domaini185 – 265Ion_trans_2InterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
KOiK04923
OrthoDBiEOG091G08DH
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR008073 TASK5
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01690 TASK5CHANNEL
PR01095 TASKCHANNEL

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B2RVL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELEPSGRTE TGTRSGRAAM RKQSARTAAL ILCILSYLLV GAAVFDALES
60 70 80 90 100
EAERSRQRLL ARKRGEFRRK YRFSADDYRE LERLALQAEP HRAGRQWRFA
110 120 130 140 150
GSFYFAITVI TTIGYGHAAP GTDSGKVFCM FYALLGIPLT LVTFQSLGER
160 170 180 190 200
LNTLVRCLLL TAKRCLGLRR PHVSAENMVV AGLLLCAATL ALGAIAFAHF
210 220 230 240 250
EGWTFFHAYY YCFITLTTIG FGDFVALQRD EALQRKPPYV AFSFLYILLG
260 270 280 290 300
LTVIGAFLNL VVLRFLASSD APERAVHRRV SVFRRGAPES RVRAGASTCI
310 320 330 340
PYPFHQLETW ARDNPAFSPP LSPEATHHCH SSPDRPRARR KSI
Length:343
Mass (Da):38,381
Last modified:July 1, 2008 - v1
Checksum:i7F96884BD5CA168B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AHD2A2AHD2_MOUSE
Potassium channel subfamily K membe...
Kcnk15
324Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731698 Genomic DNA No translation available.
BC147255 mRNA Translation: AAI47256.1
BC147256 mRNA Translation: AAI47257.1
RefSeqiNP_001025463.1, NM_001030292.1
UniGeneiMm.295337

Genome annotation databases

EnsembliENSMUST00000044798; ENSMUSP00000048326; ENSMUSG00000035238
GeneIDi241769
KEGGimmu:241769
UCSCiuc008ntn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731698 Genomic DNA No translation available.
BC147255 mRNA Translation: AAI47256.1
BC147256 mRNA Translation: AAI47257.1
RefSeqiNP_001025463.1, NM_001030292.1
UniGeneiMm.295337

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048326

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044798; ENSMUSP00000048326; ENSMUSG00000035238
GeneIDi241769
KEGGimmu:241769
UCSCiuc008ntn.1 mouse

Organism-specific databases

CTDi60598
MGIiMGI:2675209 Kcnk15

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
KOiK04923
OrthoDBiEOG091G08DH
TreeFamiTF313947

Enzyme and pathway databases

ReactomeiR-MMU-5576886 Phase 4 - resting membrane potential

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035238 Expressed in 20 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR008073 TASK5
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01690 TASK5CHANNEL
PR01095 TASKCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiB2RVL1_MOUSE
AccessioniPrimary (citable) accession number: B2RVL1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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