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Protein

von Willebrand factor C domain-containing protein 2-like

Gene

VWC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor C domain-containing protein 2-like
Alternative name(s):
Brorin-like
Gene namesi
Name:VWC2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000174453.9
HGNCiHGNC:37203 VWC2L
neXtProtiNX_B2RUY7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi402117
OpenTargetsiENSG00000174453
PharmGKBiPA165697841

Polymorphism and mutation databases

BioMutaiVWC2L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000034806022 – 222von Willebrand factor C domain-containing protein 2-likeAdd BLAST201

Proteomic databases

PaxDbiB2RUY7
PRIDEiB2RUY7
ProteomicsDBi3456
3457 [B2RUY7-2]

PTM databases

iPTMnetiB2RUY7
PhosphoSitePlusiB2RUY7

Expressioni

Gene expression databases

BgeeiENSG00000174453 Expressed in 22 organ(s), highest expression level in hypothalamus
ExpressionAtlasiB2RUY7 baseline and differential

Organism-specific databases

HPAiHPA044815
HPA059414

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi135334, 11 interactors
IntActiB2RUY7, 28 interactors
STRINGi9606.ENSP00000308976

Structurei

3D structure databases

ProteinModelPortaliB2RUY7
SMRiB2RUY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 110VWFC 1PROSITE-ProRule annotationAdd BLAST60
Domaini114 – 172VWFC 2PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHPX Eukaryota
ENOG410XTA9 LUCA
GeneTreeiENSGT00720000108792
HOGENOMiHOG000036086
HOVERGENiHBG068398
InParanoidiB2RUY7
OMAiCTICRCH
OrthoDBiEOG091G0Q3M
PhylomeDBiB2RUY7
TreeFamiTF329913

Family and domain databases

InterProiView protein in InterPro
IPR001007 VWF_dom
SMARTiView protein in SMART
SM00214 VWC, 2 hits
PROSITEiView protein in PROSITE
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: B2RUY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALHIHEACI LLLVIPGLVT SAAISHEDYP ADEGDQISSN DNLIFDDYRG
60 70 80 90 100
KGCVDDSGFV YKLGERFFPG HSNCPCVCAL DGPVCDQPEC PKIHPKCTKV
110 120 130 140 150
EHNGCCPECK EVKNFCEYHG KNYKILEEFK PSPCEWCRCE PSNEVHCVVA
160 170 180 190 200
DCAVPECVNP VYEPEQCCPV CKNGPNCFAG TTIIPAGIEV KVDECNICHC
210 220
HNGDWWKPAQ CSKRECQGKQ TV
Length:222
Mass (Da):24,570
Last modified:September 2, 2008 - v1
Checksum:i7047CE3CBA835B54
GO
Isoform 2 (identifier: B2RUY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-138: PSPCEWCR → VCVTLHIY
     139-222: Missing.

Show »
Length:138
Mass (Da):15,394
Checksum:iA6E25B068821A555
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZW27B7ZW27_HUMAN
VWC2L protein
VWC2L
139Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035088131 – 138PSPCEWCR → VCVTLHIY in isoform 2. Curated8
Alternative sequenceiVSP_035089139 – 222Missing in isoform 2. CuratedAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB374231 mRNA Translation: BAH04176.1
EU541473 mRNA Translation: ACD62527.1
AC107218 Genomic DNA No translation available.
BC146903 mRNA Translation: AAI46904.1
BC146911 mRNA Translation: AAI46912.1
BC146931 mRNA Translation: AAI46932.1
BC146935 mRNA Translation: AAI46936.1
CCDSiCCDS46509.1 [B2RUY7-1]
RefSeqiNP_001073969.1, NM_001080500.3 [B2RUY7-1]
UniGeneiHs.534834

Genome annotation databases

EnsembliENST00000312504; ENSP00000308976; ENSG00000174453 [B2RUY7-1]
GeneIDi402117
KEGGihsa:402117
UCSCiuc002vet.3 human [B2RUY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVWC2L_HUMAN
AccessioniPrimary (citable) accession number: B2RUY7
Secondary accession number(s): A6NC69, B2RUW7, B7X8X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 12, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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