The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - B2RUS7 (B2RUS7_MOUSE)
Protein
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Gene
Abcc8
Organism
Mus musculus (Mouse)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 713 – 720 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1385 – 1392 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type transporter activity Source: InterPro
- ATPase-coupled cation transmembrane transporter activity Source: MGI
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
- potassium channel activity Source: MGI
- sulfonylurea receptor activity Source: InterPro
- transmembrane transporter binding Source: MGI
GO - Biological processi
- cellular glucose homeostasis Source: MGI
- cellular response to organic substance Source: MGI
- female pregnancy Source: Ensembl
- memory Source: MGI
- negative regulation of angiogenesis Source: MGI
- negative regulation of blood-brain barrier permeability Source: MGI
- negative regulation of glial cell proliferation Source: MGI
- negative regulation of insulin secretion Source: MGI
- negative regulation of low-density lipoprotein particle clearance Source: MGI
- negative regulation of neuroblast migration Source: MGI
- negative regulation of neurogenesis Source: MGI
- negative regulation of wound healing Source: MGI
- positive regulation of potassium ion transport Source: MGI
- positive regulation of tight junction disassembly Source: MGI
- positive regulation of tumor necrosis factor production Source: MGI
- positive regulation of uterine smooth muscle relaxation Source: MGI
- positive regulation of voltage-gated potassium channel activity Source: MGI
- potassium ion import across plasma membrane Source: ComplexPortal
- response to insulin Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to pH Source: MGI
- response to xenobiotic stimulus Source: Ensembl
- response to zinc ion Source: MGI
- transmembrane transport Source: GO_Central
- visual learning Source: MGI
Keywordsi
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1296025, ATP sensitive Potassium channels R-MMU-422356, Regulation of insulin secretion |
Names & Taxonomyi
Protein namesi | Submitted name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8Imported |
Gene namesi | Name:Abcc8Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352629, Abcc8 |
VEuPathDBi | HostDB:ENSMUSG00000040136 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: Ensembl
Plasma Membrane
- inward rectifying potassium channel Source: MGI
- plasma membrane Source: MGI
- sarcolemma Source: MGI
Other locations
- membrane Source: GO_Central
- synaptic vesicle membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 52 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 73 – 94 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 106 – 124 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 136 – 155 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 161 – 185 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 307 – 324 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 351 – 368 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 430 – 454 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 460 – 478 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 536 – 559 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 571 – 593 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1010 – 1028 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1069 – 1095 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 1162 – 1184 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000040136, Expressed in islet of Langerhans and 240 other tissues |
Interactioni
Subunit structurei
Interacts with KCNJ11.
ARBA annotationGO - Molecular functioni
- transmembrane transporter binding Source: MGI
Protein-protein interaction databases
ComplexPortali | CPX-194, Inward rectifying potassium channel complex, Kir6.2-SUR1 |
DIPi | DIP-58644N |
IntActi | B2RUS7, 2 interactors |
STRINGi | 10090.ENSMUSP00000033123 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 300 – 602 | ABC transmembrane type-1InterPro annotationAdd BLAST | 303 | |
Domaini | 679 – 936 | ABC transporterInterPro annotationAdd BLAST | 258 | |
Domaini | 1021 – 1312 | ABC transmembrane type-1InterPro annotationAdd BLAST | 292 | |
Domaini | 1351 – 1585 | ABC transporterInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 945 – 968 | DisorderedSequence analysisAdd BLAST | 24 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 969 – 989 | Sequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000156626 |
HOGENOMi | CLU_000604_27_1_1 |
OMAi | ANTVVLW |
OrthoDBi | 138195at2759 |
TreeFami | TF105201 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR000844, ABCC8 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01093, SULFNYLUR1 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
B2RUS7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG
60 70 80 90 100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE
110 120 130 140 150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK
160 170 180 190 200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEINVI RVRRYIFFKT
210 220 230 240 250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HRKPIDLRAI
260 270 280 290 300
GKLPIAMRAL TNYQRLCAAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV
310 320 330 340 350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE
360 370 380 390 400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM
410 420 430 440 450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI
460 470 480 490 500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN
510 520 530 540 550
EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT SISIFMNTAI
560 570 580 590 600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST
610 620 630 640 650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR
660 670 680 690 700
PAREEVRDLL GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT
710 720 730 740 750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QRVSGAVFWN SSLPDSEGED
760 770 780 790 800
PRYCLRTSNP ERETAADSDA RSRGPVAYAS QKPWLLNATV EENITFESPF
810 820 830 840 850
NKQRYKMVIE ACSLQPDIDI LPHGDQTQIG ERGINLSGGQ RQRISVARAL
860 870 880 890 900
YQHTNVVFLD DPFSALDVHL SDHLMQAGIL ELLRDDKRTV VLVTHKLQYL
910 920 930 940 950
PHADWIIAMK DGTIQREGTL KDFQRSECQL FEHWKTLMNR QDQELEKETV
960 970 980 990 1000
MERKAPEPSQ GLPRAMSSRD GLLLDEDEEE EEAAESEEDD NLSSVLHQRA
1010 1020 1030 1040 1050
KIPWRACTKY LSSAGVLLLS LLVFSQLLKH MVLVAIDYWL AKWTDSALVL
1060 1070 1080 1090 1100
SPAARNCSLS QECALDQSVY AMVFTVLCSL GIALCLVTSV TVEWTGLKVA
1110 1120 1130 1140 1150
KRLHRSLLNR IILAPMRFFE TTPLGSILNR FSSDCNTIDQ HIPSTLECLS
1160 1170 1180 1190 1200
RSTLLCVSAL TVISYVTPVF LVALLPLAVV CYFIQKYFRV ASRDLQQLDD
1210 1220 1230 1240 1250
TTQLPLLSHF AETVEGLTTI RAFRYEARFQ QKLLEYTDSN NIASLFLTAA
1260 1270 1280 1290 1300
NRWLEVRMEY IGACVVLIAA ATSISNSLHR ELSAGLVGLG LTYALMVSNY
1310 1320 1330 1340 1350
LNWMVRNLAD MEIQLGAVKR IHTLLKTEAE SYEGLLAPSL IPKNWPDQGK
1360 1370 1380 1390 1400
IQIQNLSVRY DSSLKPVLKH VNALIAPGQK IGICGRTGSG KSSFSLAFFR
1410 1420 1430 1440 1450
MVDMFEGRII IDGIDIAKLP LHTLRSRLSI ILQDPVLFSG TIRFNLDPEK
1460 1470 1480 1490 1500
KCSDSTLWEA LEIAQLKLVV KALPGGLDAI ITEGGENFSQ GQRQLFCLAR
1510 1520 1530 1540 1550
AFVRKTSIFI MDEATASIDM ATENILQKVV MTAFADRTVV TIAHRVHTIL
1560 1570 1580
SADLVMVLKR GAILEFDKPE KLLSQKDSVF ASFVRADK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GT25 | A0A1B0GT25_MOUSE | ATP-binding cassette, sub-family C ... | Abcc8 | 910 | Annotation score: | ||
A0A1B0GT49 | A0A1B0GT49_MOUSE | ATP-binding cassette, sub-family C ... | Abcc8 | 100 | Annotation score: | ||
A0A1B0GRD7 | A0A1B0GRD7_MOUSE | ATP-binding cassette, sub-family C ... | Abcc8 | 158 | Annotation score: | ||
A0A1B0GSG2 | A0A1B0GSG2_MOUSE | ATP-binding cassette, sub-family C ... | Abcc8 | 123 | Annotation score: | ||
A0A1B0GR95 | A0A1B0GR95_MOUSE | ATP-binding cassette, sub-family C ... | Abcc8 | 73 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC141411 mRNA Translation: AAI41412.1 |
RefSeqi | NP_035640.2, NM_011510.3 |
Genome annotation databases
Ensembli | ENSMUST00000033123.8; ENSMUSP00000033123.7; ENSMUSG00000040136.11 |
GeneIDi | 20927 |
UCSCi | uc009gye.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC141411 mRNA Translation: AAI41412.1 |
RefSeqi | NP_035640.2, NM_011510.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
ComplexPortali | CPX-194, Inward rectifying potassium channel complex, Kir6.2-SUR1 |
DIPi | DIP-58644N |
IntActi | B2RUS7, 2 interactors |
STRINGi | 10090.ENSMUSP00000033123 |
Proteomic databases
ProteomicsDBi | 338937 |
Protocols and materials databases
Antibodypediai | 24846, 315 antibodies from 36 providers |
DNASUi | 20927 |
Genome annotation databases
Ensembli | ENSMUST00000033123.8; ENSMUSP00000033123.7; ENSMUSG00000040136.11 |
GeneIDi | 20927 |
UCSCi | uc009gye.1, mouse |
Organism-specific databases
CTDi | 6833 |
MGIi | MGI:1352629, Abcc8 |
VEuPathDBi | HostDB:ENSMUSG00000040136 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
GeneTreei | ENSGT00940000156626 |
HOGENOMi | CLU_000604_27_1_1 |
OMAi | ANTVVLW |
OrthoDBi | 138195at2759 |
TreeFami | TF105201 |
Enzyme and pathway databases
Reactomei | R-MMU-1296025, ATP sensitive Potassium channels R-MMU-422356, Regulation of insulin secretion |
Miscellaneous databases
BioGRID-ORCSi | 20927, 1 hit in 72 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040136, Expressed in islet of Langerhans and 240 other tissues |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR000844, ABCC8 IPR027417, P-loop_NTPase IPR000388, Sulphorea_rcpt |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
PRINTSi | PR01093, SULFNYLUR1 PR01092, SULFNYLUREAR |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RUS7_MOUSE | |
Accessioni | B2RUS7Primary (citable) accession number: B2RUS7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |