ATP-binding cassette, sub-family C (CFTR/MRP), member 8

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase activity, coupled to transmembrane movement of substances Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• ATP binding Source: UniProtKB-UniRule
• ion channel binding Source: MGI
• potassium channel activity Source: MGI
• sulfonylurea receptor activity Source: InterPro

GO - Biological processⁱ

• cellular glucose homeostasis Source: MGI
• cellular response to organic substance Source: MGI
• female pregnancy Source: Ensembl
• memory Source: MGI
• negative regulation of angiogenesis Source: MGI
• negative regulation of glial cell proliferation Source: MGI
• negative regulation of insulin secretion Source: MGI
• negative regulation of low-density lipoprotein particle clearance Source: MGI
• negative regulation of maintenance of permeability of blood-brain barrier Source: MGI
• negative regulation of neuroblast migration Source: MGI
• negative regulation of neurogenesis Source: MGI
• negative regulation of wound healing Source: MGI
• positive regulation of potassium ion transport Source: MGI
• positive regulation of tight junction disassembly Source: MGI
• positive regulation of tumor necrosis factor production Source: MGI
• positive regulation of uterine smooth muscle relaxation Source: MGI
• positive regulation of voltage-gated potassium channel activity Source: MGI
• response to drug Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to insulin Source: Ensembl
• response to lipopolysaccharide Source: Ensembl
• response to pH Source: MGI
• response to zinc ion Source: MGI
• transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• visual learning Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• ion channel binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG 
        60         70         80         90        100
WGSQSSKVHI HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE 
       110        120        130        140        150
SRHLHLYMPA GMAFMAAITS VVYYHNIETS NFPKLLIALL IYWTLAFITK 
       160        170        180        190        200
TIKFVKFYDH AIGFSQLRFC LTGLLVILYG MLLLVEINVI RVRRYIFFKT 
       210        220        230        240        250
PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA HRKPIDLRAI 
       260        270        280        290        300
GKLPIAMRAL TNYQRLCAAF DAQARKDTQS QQGARAIWRA LCHAFGRRLV 
       310        320        330        340        350
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE 
       360        370        380        390        400
FLGNAYVLAV LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM 
       410        420        430        440        450
HLSTSNLSMG EMTAGQICNL VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI 
       460        470        480        490        500
LLYYILGVSA LIGAAVIILL APVQYFVATK LSQAQRSTLE YSNERLKQTN 
       510        520        530        540        550
EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT SISIFMNTAI 
       560        570        580        590        600
PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 
       610        620        630        640        650
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR 
       660        670        680        690        700
PAREEVRDLL GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT 
       710        720        730        740        750
IRIPRGQLTM IVGQVGCGKS SLLLATLGEM QRVSGAVFWN SSLPDSEGED 
       760        770        780        790        800
PRYCLRTSNP ERETAADSDA RSRGPVAYAS QKPWLLNATV EENITFESPF 
       810        820        830        840        850
NKQRYKMVIE ACSLQPDIDI LPHGDQTQIG ERGINLSGGQ RQRISVARAL 
       860        870        880        890        900
YQHTNVVFLD DPFSALDVHL SDHLMQAGIL ELLRDDKRTV VLVTHKLQYL 
       910        920        930        940        950
PHADWIIAMK DGTIQREGTL KDFQRSECQL FEHWKTLMNR QDQELEKETV 
       960        970        980        990       1000
MERKAPEPSQ GLPRAMSSRD GLLLDEDEEE EEAAESEEDD NLSSVLHQRA 
      1010       1020       1030       1040       1050
KIPWRACTKY LSSAGVLLLS LLVFSQLLKH MVLVAIDYWL AKWTDSALVL 
      1060       1070       1080       1090       1100
SPAARNCSLS QECALDQSVY AMVFTVLCSL GIALCLVTSV TVEWTGLKVA 
      1110       1120       1130       1140       1150
KRLHRSLLNR IILAPMRFFE TTPLGSILNR FSSDCNTIDQ HIPSTLECLS 
      1160       1170       1180       1190       1200
RSTLLCVSAL TVISYVTPVF LVALLPLAVV CYFIQKYFRV ASRDLQQLDD 
      1210       1220       1230       1240       1250
TTQLPLLSHF AETVEGLTTI RAFRYEARFQ QKLLEYTDSN NIASLFLTAA 
      1260       1270       1280       1290       1300
NRWLEVRMEY IGACVVLIAA ATSISNSLHR ELSAGLVGLG LTYALMVSNY 
      1310       1320       1330       1340       1350
LNWMVRNLAD MEIQLGAVKR IHTLLKTEAE SYEGLLAPSL IPKNWPDQGK 
      1360       1370       1380       1390       1400
IQIQNLSVRY DSSLKPVLKH VNALIAPGQK IGICGRTGSG KSSFSLAFFR 
      1410       1420       1430       1440       1450
MVDMFEGRII IDGIDIAKLP LHTLRSRLSI ILQDPVLFSG TIRFNLDPEK 
      1460       1470       1480       1490       1500
KCSDSTLWEA LEIAQLKLVV KALPGGLDAI ITEGGENFSQ GQRQLFCLAR 
      1510       1520       1530       1540       1550
AFVRKTSIFI MDEATASIDM ATENILQKVV MTAFADRTVV TIAHRVHTIL 
      1560       1570       1580 
SADLVMVLKR GAILEFDKPE KLLSQKDSVF ASFVRADK              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ