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Entry version 64 (31 Jul 2019)
Sequence version 1 (01 Jul 2008)
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Protein
Submitted name:

eIF4G1 protein

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
eIF4G1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4G1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B2RU10

PRoteomics IDEntifications database

More...
PRIDEi
B2RU10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B2RU10 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2RU10

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1248 – 1370MIInterPro annotationAdd BLAST123
Domaini1440 – 1606W2InterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 84DisorderedSequence analysisAdd BLAST84
Regioni173 – 229DisorderedSequence analysisAdd BLAST57
Regioni241 – 607DisorderedSequence analysisAdd BLAST367
Regioni675 – 720DisorderedSequence analysisAdd BLAST46
Regioni738 – 764DisorderedSequence analysisAdd BLAST27
Regioni1031 – 1234DisorderedSequence analysisAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 26Pro-richSequence analysisAdd BLAST20
Compositional biasi30 – 52PolarSequence analysisAdd BLAST23
Compositional biasi60 – 74PolarSequence analysisAdd BLAST15
Compositional biasi181 – 197PolyampholyteSequence analysisAdd BLAST17
Compositional biasi205 – 225PolarSequence analysisAdd BLAST21
Compositional biasi262 – 280Pro-richSequence analysisAdd BLAST19
Compositional biasi292 – 310PolarSequence analysisAdd BLAST19
Compositional biasi342 – 357PolarSequence analysisAdd BLAST16
Compositional biasi384 – 401Pro-richSequence analysisAdd BLAST18
Compositional biasi441 – 458PolarSequence analysisAdd BLAST18
Compositional biasi460 – 478AcidicSequence analysisAdd BLAST19
Compositional biasi497 – 511PolarSequence analysisAdd BLAST15
Compositional biasi571 – 593PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1066 – 1094PolarSequence analysisAdd BLAST29
Compositional biasi1119 – 1148PolarSequence analysisAdd BLAST30
Compositional biasi1149 – 1230PolyampholyteSequence analysisAdd BLAST82

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0401 Eukaryota
ENOG410XS4P LUCA

Database of Orthologous Groups

More...
OrthoDBi
594395at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23253:SF10 PTHR23253:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RU10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG
60 70 80 90 100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ
110 120 130 140 150
ISYPASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG
160 170 180 190 200
AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT
210 220 230 240 250
EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD DRSQGAIIAD
260 270 280 290 300
RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI
310 320 330 340 350
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS
360 370 380 390 400
PLQAPTPLAS HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP
410 420 430 440 450
IAPTAQPEEL LNGAPSPPAV DLSPVSEPEE QAKEVTASMA PPTIPSATPA
460 470 480 490 500
TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE AESEKGGEEL LPPESTPIPA
510 520 530 540 550
NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEANPAVPE
560 570 580 590 600
VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK
610 620 630 640 650
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK
660 670 680 690 700
ANKTPLRPLD PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP
710 720 730 740 750
RGPAGLGPRR SQQGPRKEPR KIIATVLMTE DIKLNKAEKA WKPSSKRTAA
760 770 780 790 800
DKDRGEEDAD GSKTQDLFRR VRSILNKLTP QMFQQLMKQV TQLAIDTEER
810 820 830 840 850
LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP TVTVNFRKLL
860 870 880 890 900
LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR
910 920 930 940 950
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG
960 970 980 990 1000
KDLDFEKAKP RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR
1010 1020 1030 1040 1050
RGDQGPKTID QIHKEAEMEE HREHIKVQQL MAKGSDKRRG GPPGPPISRG
1060 1070 1080 1090 1100
LPLVDDGGWN TVPISKGSRP IDTSRLTKIT KPGSIDSNNQ LFAPGGRLSW
1110 1120 1130 1140 1150
GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE STDNRRVVQR
1160 1170 1180 1190 1200
SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER
1210 1220 1230 1240 1250
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE
1260 1270 1280 1290 1300
KKSKAIIEEY LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA
1310 1320 1330 1340 1350
REHMGQLLHQ LLCAGHLSTA QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL
1360 1370 1380 1390 1400
VTPILQEGGV PMGELFREIT KPLRPLGKAA SLLLEILGLL CKSMGPKKVG
1410 1420 1430 1440 1450
TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP GQRALPSEEL
1460 1470 1480 1490 1500
NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF
1510 1520 1530 1540 1550
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR
1560 1570 1580 1590 1600
MFFDALYDED VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE

EESDHN
Length:1,606
Mass (Da):176,207
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD3BD97634837A9D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC140896 mRNA Translation: AAI40897.1

NCBI Reference Sequences

More...
RefSeqi
NP_001181875.1, NM_001194946.1
NP_001181876.1, NM_001194947.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1981

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140896 mRNA Translation: AAI40897.1
RefSeqiNP_001181875.1, NM_001194946.1
NP_001181876.1, NM_001194947.1

3D structure databases

SMRiB2RU10
ModBaseiSearch...

Proteomic databases

PeptideAtlasiB2RU10
PRIDEiB2RU10

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1981

Genome annotation databases

GeneIDi1981

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1981

Phylogenomic databases

eggNOGiKOG0401 Eukaryota
ENOG410XS4P LUCA
OrthoDBi594395at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EIF4G1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1981

Gene expression databases

GenevisibleiB2RU10 HS

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF10 PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RU10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RU10
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 31, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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