UniProtKB - B2RU06 (B2RU06_HUMAN)
Protein
Submitted name:
eIF4G1 protein
Gene
EIF4G1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- eukaryotic initiation factor 4E binding Source: AgBase
- mRNA binding Source: InterPro
- translation initiation factor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Initiation factorARBA annotation |
Biological process | Protein biosynthesis |
Names & Taxonomyi
Protein namesi | Submitted name: eIF4G1 proteinImported |
Gene namesi | Name:EIF4G1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- cytoplasm Source: AgBase
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1248 – 1370 | MIInterPro annotationAdd BLAST | 123 | |
Domaini | 1440 – 1606 | W2InterPro annotationAdd BLAST | 167 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 173 – 229 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 241 – 606 | DisorderedSequence analysisAdd BLAST | 366 | |
Regioni | 675 – 720 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 738 – 764 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 1031 – 1234 | DisorderedSequence analysisAdd BLAST | 204 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 26 | Pro-richSequence analysisAdd BLAST | 20 | |
Compositional biasi | 30 – 52 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 60 – 74 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 181 – 197 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 205 – 225 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 262 – 280 | Pro-richSequence analysisAdd BLAST | 19 | |
Compositional biasi | 292 – 310 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 342 – 357 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 384 – 401 | Pro-richSequence analysisAdd BLAST | 18 | |
Compositional biasi | 441 – 458 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 460 – 478 | AcidicSequence analysisAdd BLAST | 19 | |
Compositional biasi | 497 – 511 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 571 – 593 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1066 – 1094 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1119 – 1148 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 1149 – 1230 | PolyampholyteSequence analysisAdd BLAST | 82 |
Sequence similaritiesi
Belongs to the eukaryotic initiation factor 4G family.ARBA annotation
Phylogenomic databases
OrthoDBi | 594395at2759 |
Family and domain databases
Gene3Di | 1.25.40.180, 3 hits |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037584, EIF4G1 IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 IPR003307, W2_domain |
PANTHERi | PTHR23253:SF10, PTHR23253:SF10, 1 hit |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit PS51363, W2, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RU06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG
60 70 80 90 100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ
110 120 130 140 150
ISYPASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG
160 170 180 190 200
AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT
210 220 230 240 250
EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD DRSQGAIIAD
260 270 280 290 300
RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI
310 320 330 340 350
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS
360 370 380 390 400
PLQAPTPLAS HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP
410 420 430 440 450
IAPTAQPEEL LNGAPSPPAV DLSPVSEPEE QAKEVTASVA PPTIPSATPA
460 470 480 490 500
TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE AESEKGGEEL LPPESTPIPA
510 520 530 540 550
NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEANPAVPE
560 570 580 590 600
VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK
610 620 630 640 650
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK
660 670 680 690 700
ANKTPLRPLD PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP
710 720 730 740 750
RGPAGLGPRR SQQGPRKEPR KIIATVLMTE DIKLNKAEKA WKPSSKRTAA
760 770 780 790 800
DKDRGEEDAD GSKTQDLFRR VRSILNKLTP QMFQQLMKQV TQLAIDTEER
810 820 830 840 850
LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP TVTVNFRKLL
860 870 880 890 900
LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR
910 920 930 940 950
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG
960 970 980 990 1000
KDLDFEKAKP RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR
1010 1020 1030 1040 1050
RGDQGPKTID QIHKEAEMEE HREHIKVQQL MAKGSDKRRG GPPGPPISRG
1060 1070 1080 1090 1100
LPLVDDGGWN TVPISKGSRP IDTSRLTKIT KPGSIDSNNQ LFAPGGRLSW
1110 1120 1130 1140 1150
GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE STDNRRVVQR
1160 1170 1180 1190 1200
SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER
1210 1220 1230 1240 1250
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE
1260 1270 1280 1290 1300
KKSKAIIEEY LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA
1310 1320 1330 1340 1350
REHMGQLLHQ LLCAGHLSTA QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL
1360 1370 1380 1390 1400
VTPILQEGGV PMGELFREIT KPLRPLGKAA SLLLEILGLL CKSMGPKKVG
1410 1420 1430 1440 1450
TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP GQRALPSEEL
1460 1470 1480 1490 1500
NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF
1510 1520 1530 1540 1550
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR
1560 1570 1580 1590 1600
MFFDALYDED VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE
EESDHN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC140892 mRNA Translation: AAI40893.1 |
RefSeqi | NP_001181875.1, NM_001194946.1 |
Genome annotation databases
GeneIDi | 1981 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC140892 mRNA Translation: AAI40893.1 |
RefSeqi | NP_001181875.1, NM_001194946.1 |
3D structure databases
SMRi | B2RU06 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B2RU06 |
PRIDEi | B2RU06 |
Protocols and materials databases
DNASUi | 1981 |
Genome annotation databases
GeneIDi | 1981 |
Organism-specific databases
CTDi | 1981 |
Phylogenomic databases
OrthoDBi | 594395at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1981, 556 hits in 847 CRISPR screens |
ChiTaRSi | EIF4G1, human |
GenomeRNAii | 1981 |
Gene expression databases
Genevisiblei | B2RU06, HS |
Family and domain databases
Gene3Di | 1.25.40.180, 3 hits |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR037584, EIF4G1 IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 IPR003307, W2_domain |
PANTHERi | PTHR23253:SF10, PTHR23253:SF10, 1 hit |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit PF02020, W2, 1 hit |
SMARTi | View protein in SMART SM00515, eIF5C, 1 hit SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit PS51363, W2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RU06_HUMAN | |
Accessioni | B2RU06Primary (citable) accession number: B2RU06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |