Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - B2RU06 (B2RU06_HUMAN)

Entry version 74 (25 May 2022)
Sequence version 1 (01 Jul 2008)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

eIF4G1 protein

Gene

EIF4G1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorARBA annotation
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
eIF4G1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4G1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		B2RU06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		B2RU06, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		B2RU06, 1 interactor

Molecular INTeraction database

More...MINTi		B2RU06

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B2RU06

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1248 – 1370MIInterPro annotationAdd BLAST123
Domaini1440 – 1606W2InterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 84DisorderedSequence analysisAdd BLAST84
Regioni173 – 229DisorderedSequence analysisAdd BLAST57
Regioni241 – 606DisorderedSequence analysisAdd BLAST366
Regioni675 – 720DisorderedSequence analysisAdd BLAST46
Regioni738 – 764DisorderedSequence analysisAdd BLAST27
Regioni1031 – 1234DisorderedSequence analysisAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 26Pro residuesSequence analysisAdd BLAST20
Compositional biasi30 – 52Polar residuesSequence analysisAdd BLAST23
Compositional biasi60 – 74Polar residuesSequence analysisAdd BLAST15
Compositional biasi181 – 197Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi205 – 225Polar residuesSequence analysisAdd BLAST21
Compositional biasi262 – 280Pro residuesSequence analysisAdd BLAST19
Compositional biasi292 – 310Polar residuesSequence analysisAdd BLAST19
Compositional biasi342 – 357Polar residuesSequence analysisAdd BLAST16
Compositional biasi384 – 401Pro residuesSequence analysisAdd BLAST18
Compositional biasi441 – 458Polar residuesSequence analysisAdd BLAST18
Compositional biasi460 – 478Acidic residuesSequence analysisAdd BLAST19
Compositional biasi497 – 511Polar residuesSequence analysisAdd BLAST15
Compositional biasi571 – 593Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1066 – 1094Polar residuesSequence analysisAdd BLAST29
Compositional biasi1119 – 1148Polar residuesSequence analysisAdd BLAST30
Compositional biasi1149 – 1230Basic and acidic residuesSequence analysisAdd BLAST82

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic initiation factor 4G family.ARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		594395at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR045208, IF4G
IPR003891, Initiation_fac_eIF4g_MI
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain

The PANTHER Classification System

More...PANTHERi		PTHR23253, PTHR23253, 1 hit
PTHR23253:SF10, PTHR23253:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RU06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKAPQSTGP PPAPSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG 
        60         70         80         90        100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAAHVYPA GSQVMMIPSQ 
       110        120        130        140        150
ISYPASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG 
       160        170        180        190        200
AYYPAQGVQQ FPTGVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT 
       210        220        230        240        250
EEIMSGARTA STPTPPQTGG GLEPQANGET PQVAVIVRPD DRSQGAIIAD 
       260        270        280        290        300
RPGLPGPEHS PSESQPSSPS PTPSPSPVLE PGSEPNLAVL SIPGDTMTTI 
       310        320        330        340        350
QMSVEESTPI SRETGEPYRL SPEPTPLAEP ILEVEVTLSK PVPESEFSSS 
       360        370        380        390        400
PLQAPTPLAS HTVEIHEPNG MVPSEDLEPE VESSPELAPP PACPSESPVP 
       410        420        430        440        450
IAPTAQPEEL LNGAPSPPAV DLSPVSEPEE QAKEVTASVA PPTIPSATPA 
       460        470        480        490        500
TAPSATSPAQ EEEMEEEEEE EEGEAGEAGE AESEKGGEEL LPPESTPIPA 
       510        520        530        540        550
NLSQNLEAAA ATQVAVSVPK RRRKIKELNK KEAVGDLLDA FKEANPAVPE 
       560        570        580        590        600
VENQPPAGSN PGPESEGSGV PPRPEEADET WDSKEDKIHN AENIQPGEQK 
       610        620        630        640        650
YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK 
       660        670        680        690        700
ANKTPLRPLD PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP 
       710        720        730        740        750
RGPAGLGPRR SQQGPRKEPR KIIATVLMTE DIKLNKAEKA WKPSSKRTAA 
       760        770        780        790        800
DKDRGEEDAD GSKTQDLFRR VRSILNKLTP QMFQQLMKQV TQLAIDTEER 
       810        820        830        840        850
LKGVIDLIFE KAISEPNFSV AYANMCRCLM ALKVPTTEKP TVTVNFRKLL 
       860        870        880        890        900
LNRCQKEFEK DKDDDEVFEK KQKEMDEAAT AEERGRLKEE LEEARDIARR 
       910        920        930        940        950
RSLGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG 
       960        970        980        990       1000
KDLDFEKAKP RMDQYFNQME KIIKEKKTSS RIRFMLQDVL DLRGSNWVPR 
      1010       1020       1030       1040       1050
RGDQGPKTID QIHKEAEMEE HREHIKVQQL MAKGSDKRRG GPPGPPISRG 
      1060       1070       1080       1090       1100
LPLVDDGGWN TVPISKGSRP IDTSRLTKIT KPGSIDSNNQ LFAPGGRLSW 
      1110       1120       1130       1140       1150
GKGSSGGSGA KPSDAASEAA RPATSTLNRF SALQQAVPTE STDNRRVVQR 
      1160       1170       1180       1190       1200
SSLSRERGEK AGDRGDRLER SERGGDRGDR LDRARTPATK RSFSKEVEER 
      1210       1220       1230       1240       1250
SRERPSQPEG LRKAASLTED RDRGRDAVKR EAALPPVSPL KAALSEEELE 
      1260       1270       1280       1290       1300
KKSKAIIEEY LHLNDMKEAV QCVQELASPS LLFIFVRHGV ESTLERSAIA 
      1310       1320       1330       1340       1350
REHMGQLLHQ LLCAGHLSTA QYYQGLYEIL ELAEDMEIDI PHVWLYLAEL 
      1360       1370       1380       1390       1400
VTPILQEGGV PMGELFREIT KPLRPLGKAA SLLLEILGLL CKSMGPKKVG 
      1410       1420       1430       1440       1450
TLWREAGLSW KEFLPEGQDI GAFVAEQKVE YTLGEESEAP GQRALPSEEL 
      1460       1470       1480       1490       1500
NRQLEKLLKE GSSNQRVFDW IEANLSEQQI VSNTLVRALM TAVCYSAIIF 
      1510       1520       1530       1540       1550
ETPLRVDVAV LKARAKLLQK YLCDEQKELQ ALYALQALVV TLEQPPNLLR 
      1560       1570       1580       1590       1600
MFFDALYDED VVKEDAFYSW ESSKDPAEQQ GKGVALKSVT AFFKWLREAE 

EESDHN
Length:1,606
Mass (Da):176,175
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A8B1B889D6D7A8D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC140892 mRNA Translation: AAI40893.1

NCBI Reference Sequences

More...RefSeqi		NP_001181875.1, NM_001194946.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1981

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140892 mRNA Translation: AAI40893.1
RefSeqiNP_001181875.1, NM_001194946.1

3D structure databases

SMRiB2RU06
ModBaseiSearch...

Protein-protein interaction databases

IntActiB2RU06, 1 interactor
MINTiB2RU06

Proteomic databases

PeptideAtlasiB2RU06

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1981

Genome annotation databases

GeneIDi1981

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1981

Phylogenomic databases

OrthoDBi594395at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1981, 581 hits in 1087 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EIF4G1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1981

Gene expression databases

GenevisibleiB2RU06, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037584, EIF4G1
IPR045208, IF4G
IPR003891, Initiation_fac_eIF4g_MI
IPR003890, MIF4G-like_typ-3
IPR003307, W2_domain
PANTHERiPTHR23253, PTHR23253, 1 hit
PTHR23253:SF10, PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847, MA3, 1 hit
PF02854, MIF4G, 1 hit
PF02020, W2, 1 hit
SMARTiView protein in SMART
SM00515, eIF5C, 1 hit
SM00544, MA3, 1 hit
SM00543, MIF4G, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366, MI, 1 hit
PS51363, W2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RU06_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RU06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 25, 2022
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again