Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - B2RTY4 (MYO9A_HUMAN)

Entry version 124 (07 Apr 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Unconventional myosin-IXa

Gene

MYO9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi239 – 246ATPSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1999 – 2048Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri2068 – 2119Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, GTPase activation, Motor protein, Myosin
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		B2RTY4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840, Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...SIGNORi		B2RTY4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-IXa
Alternative name(s):
Unconventional myosin-9a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO9A
Synonyms:MYR7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7608, MYO9A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604875, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_B2RTY4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000066933.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei175 – 195HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myasthenic syndrome, congenital, 24, presynaptic (CMS24)3 Publications
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features include easy fatigability and muscle weakness. CMS24 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081671203Y → C in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374155761EnsemblClinVar.1
Natural variantiVAR_082148513 – 2548Missing in CMS24; unknown pathological significance. 1 PublicationAdd BLAST2036
Natural variantiVAR_0816721517R → H in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149046541Ensembl.1
Natural variantiVAR_0816731698D → G in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs150726107Ensembl.1
Natural variantiVAR_0816742282G → E in CMS24; unknown pathological significance. 1 Publication1
Natural variantiVAR_0816752283R → H in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs142345927EnsemblClinVar.1

Keywords - Diseasei

Congenital myasthenic syndrome, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		4649

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MYO9A

MalaCards human disease database

More...MalaCardsi		MYO9A
MIMi618198, phenotype

Open Targets

More...OpenTargetsi		ENSG00000066933

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98914, Presynaptic congenital myasthenic syndromes

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31413

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		B2RTY4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYO9A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003484401 – 2548Unconventional myosin-IXaAdd BLAST2548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei755PhosphoserineBy similarity1
Modified residuei1242PhosphoserineBy similarity1
Modified residuei1258PhosphoserineBy similarity1
Modified residuei1299PhosphoserineCombined sources1
Modified residuei1317PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1948PhosphoserineBy similarity1
Modified residuei2294PhosphoserineCombined sources1
Modified residuei2464PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		B2RTY4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		B2RTY4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		B2RTY4

MaxQB - The MaxQuant DataBase

More...MaxQBi		B2RTY4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		B2RTY4

PeptideAtlas

More...PeptideAtlasi		B2RTY4

PRoteomics IDEntifications database

More...PRIDEi		B2RTY4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3450 [B2RTY4-1]
3451 [B2RTY4-2]
3452 [B2RTY4-3]
3453 [B2RTY4-4]
3454 [B2RTY4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		B2RTY4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		B2RTY4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found to be expressed in testis and placenta and at lower levels in all the examined tissues with the exception of liver (PubMed:10409426). Isoform 5: Found in leukocytes but not in brain, retina or testis (PubMed:10409426).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000066933, Expressed in calcaneal tendon and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B2RTY4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		B2RTY4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000066933, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110733, 57 interactors

Protein interaction database and analysis system

More...IntActi		B2RTY4, 29 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348349

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		B2RTY4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 112Ras-associatingPROSITE-ProRule annotationAdd BLAST99
Domaini146 – 1016Myosin motorPROSITE-ProRule annotationAdd BLAST871
Domaini1021 – 1041IQ 1PROSITE-ProRule annotationAdd BLAST21
Domaini1042 – 1071IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini1074 – 1103IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini1115 – 1144IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1138 – 1167IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini2063 – 2251Rho-GAPPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni898 – 920Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1021 – 1162Neck or regulatory domainAdd BLAST142
Regioni1163 – 2511TailAdd BLAST1349

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1264 – 1291Sequence analysisAdd BLAST28
Coiled coili1486 – 1532Sequence analysisAdd BLAST47
Coiled coili2315 – 2358Sequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1999 – 2048Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST50
Zinc fingeri2068 – 2119Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1453, Eukaryota
KOG4229, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154905

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000192_7_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B2RTY4

Identification of Orthologs from Complete Genome Data

More...OMAi		KYQAANM

Database of Orthologous Groups

More...OrthoDBi		14881at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		B2RTY4

TreeFam database of animal gene trees

More...TreeFami		TF316834

Family and domain databases

Conserved Domains Database

More...CDDi		cd00029, C1, 1 hit
cd01385, MYSc_Myo9, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
3.40.850.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR028558, MYO9A
IPR001609, Myosin_head_motor_dom
IPR036023, MYSc_Myo9
IPR027417, P-loop_NTPase
IPR002219, PE/DAG-bd
IPR000159, RA_dom
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR46184:SF3, PTHR46184:SF3, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00612, IQ, 4 hits
PF00063, Myosin_head, 2 hits
PF00788, RA, 1 hit
PF00620, RhoGAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00109, C1, 1 hit
SM00015, IQ, 5 hits
SM00242, MYSc, 1 hit
SM00314, RA, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 2 hits
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50096, IQ, 4 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS50200, RA, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B2RTY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEVIESLI 
        60         70         80         90        100
NKLHLDKTKC YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG 
       110        120        130        140        150
EDYRFLLREK NLDGSIHYGS LQSWLRVTEE RRRMMERGFL PQPQQKDFDD 
       160        170        180        190        200
LCSLPDLNEK TLLENLRNRF KHEKIYTYVG SILIVINPFK FLPIYNPKYV 
       210        220        230        240        250
KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE SGSGKTQSTN 
       260        270        280        290        300
FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI 
       310        320        330        340        350
QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEDER 
       360        370        380        390        400
SAFHLKQPEE YHYLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE 
       410        420        430        440        450
RLQLAMEMVG FLPKTRRQIF SLLSAILHLG NICYKKKTYR DDSIDICNPE 
       460        470        480        490        500
VLPIVSELLE VKEEMLFEAL VTRKTVTVGE KLILPYKLAE AVTVRNSMAK 
       510        520        530        540        550
SLYSALFDWI VFRINHALLN SKDLEHNTKT LSIGVLDIFG FEDYENNSFE 
       560        570        580        590        600
QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS 
       610        620        630        640        650
KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEDNSYIEF PAVMEPAFII 
       660        670        680        690        700
KHYAGKVKYG VKDFREKNTD HMRPDIVALL RSSKNAFISG MIGIDPVAVF 
       710        720        730        740        750
RWAILRAFFR AMVAFREAGK RNIHRKTGHD DTAPCAILKS MDSFSFLQHP 
       760        770        780        790        800
VHQRSLEILQ RCKEEKYSIT RKNPRTPLSD LQGMNALNEK NQHDTFDIAW 
       810        820        830        840        850
NGRTGIRQSR LSSGTSLLDK DGIFANSTSS KLLERAHGIL TRNKNFKSKP 
       860        870        880        890        900
ALPKHLLEVN SLKHLTRLTL QDRITKSLLH LHKKKKPPSI SAQFQASLSK 
       910        920        930        940        950
LMETLGQAEP YFVKCIRSNA EKLPLRFSDV LVLRQLRYTG MLETVRIRQS 
       960        970        980        990       1000
GYSSKYSFQD FVSHFHVLLP RNIIPSKFNI QDFFRKINLN PDNYQVGKTM 
      1010       1020       1030       1040       1050
VFLKEQERQH LQDLLHQEVL RRIILLQRWF RVLLCRQHFL HLRQASVIIQ 
      1060       1070       1080       1090       1100
RFWRNYLNQK QVRDAAVQKD AFVMASAAAL LQASWRAHLE RQRYLELRAA 
      1110       1120       1130       1140       1150
AIVIQQKWRD YYRRRHMAAI CIQARWKAYR ESKRYQEQRK KIILLQSTCR 
      1160       1170       1180       1190       1200
GFRARQRFKA LKEQRLRETK PEVGLVNIKG YGSLEIQGSD PSGWEDCSFD 
      1210       1220       1230       1240       1250
NRIKAIEECK SVIESNRISR ESSVDCLKES PNKQQERAQS QSGVDLQEDV 
      1260       1270       1280       1290       1300
LVRERPRSLE DLHQKKVGRA KRESRRMREL EQAIFSLELL KVRSLGGISP 
      1310       1320       1330       1340       1350
SEDRRWSTEL VPEGLQSPRG TPDSESSQGS LELLSYEESQ KSKLESVISD 
      1360       1370       1380       1390       1400
EGDLQFPSPK ISSSPKFDSR DNALSASNET SSAEHLKDGT MKEMVVCSSE 
      1410       1420       1430       1440       1450
SITCKPQLKD SFISNSLPTF FYIPQQDPLK TNSQLDTSIQ RNKLLENEDT 
      1460       1470       1480       1490       1500
AGEALTLDIN RETRRYHCSG KDQIVPSLNT ESSNPVLKKL EKLNTEKEER 
      1510       1520       1530       1540       1550
QKQLQQQNEK EMMEQIRQQT DILEKERKAF KTIEKPRIGE CLVAPSSYQS 
      1560       1570       1580       1590       1600
KQRVERPSSL LSLNTSNKGE LNVLGSLSLK DAALAQKDSS SAHLPPKDRP 
      1610       1620       1630       1640       1650
VTVFFERKGS PCQSSTVKEL SKTDRMGTQL NVACKLSNNR ISKREHFRPT 
      1660       1670       1680       1690       1700
QSYSHNSDDL SREGNARPIF FTPKDNMSIP LVSKEALNSK NPQLHKEDEP 
      1710       1720       1730       1740       1750
AWKPVKLAGP GQRETSQRFS SVDEQAKLHK TMSQGEITKL AVRQKASDSD 
      1760       1770       1780       1790       1800
IRPQRAKMRF WAKGKQGEKK TTRVKPTTQS EVSPLFAGTD VIPAHQFPDE 
      1810       1820       1830       1840       1850
LAAYHPTPPL SPELPGSCRK EFKENKEPSP KAKRKRSVKI SNVALDSMHW 
      1860       1870       1880       1890       1900
QNDSVQIIAS VSDLKSMDEF LLKKVNDLDN EDSKKDTLVD VVFKKALKEF 
      1910       1920       1930       1940       1950
RQNIFSFYSS ALAMDDGKSI RYKDLYALFE QILEKTMRLE QRDSLGESPV 
      1960       1970       1980       1990       2000
RVWVNTFKVF LDEYMNEFKT SDCTATKVPK TERKKRRKKE TDLVEEHNGH 
      2010       2020       2030       2040       2050
IFKATQYSIP TYCEYCSSLI WIMDRASVCK LCKYACHKKC CLKTTAKCSK 
      2060       2070       2080       2090       2100
KYDPELSSRQ FGVELSRLTS EDRTVPLVVE KLINYIEMHG LYTEGIYRKS 
      2110       2120       2130       2140       2150
GSTNKIKELR QGLDTDAESV NLDDYNIHVI ASVFKQWLRD LPNPLMTFEL 
      2160       2170       2180       2190       2200
YEEFLRAMGL QERKETIRGV YSVIDQLSRT HLNTLERLIF HLVRIALQED 
      2210       2220       2230       2240       2250
TNRMSANALA IVFAPCILRC PDTTDPLQSV QDISKTTTCV ELIVVEQMNK 
      2260       2270       2280       2290       2300
YKARLKDISS LEFAENKAKT RLSLIRRSMG KGRIRRGNYP GPSSPVVVRL 
      2310       2320       2330       2340       2350
PSVSDVSEET LTSEAAMETD ITEQQQAAMQ QEERVLTEQI ENLQKEKEEL 
      2360       2370       2380       2390       2400
TFEMLVLEPR ASDDETLESE ASIGTADSSE NLNMESEYAI SEKSERSLAL 
      2410       2420       2430       2440       2450
SSLKTAGKSE PSSKLRKQLK KQQDSLDVVD SSVSSLCLSN TASSHGTRKL 
      2460       2470       2480       2490       2500
FQIYSKSPFY RAASGNEALG MEGPLGQTKF LEDKPQFISR GTFNPEKGKQ 
      2510       2520       2530       2540 
KLKNVKNSPQ KTKETPEGTV MSGRRKTVDP DCTSNQQLAL FGNNEFMV
Length:2,548
Mass (Da):292,706
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i867835BD2B841C84
GO
Isoform 2 (identifier: B2RTY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-385: Missing.

Show »
Length:2,529
Mass (Da):290,379
Checksum:i6024586FEA633B1C
GO
Isoform 3 (identifier: B2RTY4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     729-729: H → K
     730-2548: Missing.

Show »
Length:729
Mass (Da):84,679
Checksum:iC7529CD8EB711767
GO
Isoform 4 (identifier: B2RTY4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1714-1714: E → EVARPAHKKKARMARTRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQASHCELGPAPSLGQASHSDSEM

Show »
Length:2,619
Mass (Da):300,433
Checksum:iE19A84D21D057FB0
GO
Isoform 5 (identifier: B2RTY4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-280: Missing.

Note: Lacks the ATP-binding domain which suggests that it cannot interact with actin.Curated
Show »
Length:2,312
Mass (Da):265,414
Checksum:iD00A255132D264DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRD5H3BRD5_HUMAN
Unconventional myosin-IXa
MYO9A
2,396Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMM1H3BMM1_HUMAN
Unconventional myosin-IXa
MYO9A
1,301Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTL9H3BTL9_HUMAN
Unconventional myosin-IXa
MYO9A
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV44H3BV44_HUMAN
Unconventional myosin-IXa
MYO9A
1,398Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU05H3BU05_HUMAN
Unconventional myosin-IXa
MYO9A
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP49H3BP49_HUMAN
Unconventional myosin-IXa
MYO9A
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMS3H3BMS3_HUMAN
Unconventional myosin-IXa
MYO9A
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSU8H3BSU8_HUMAN
Unconventional myosin-IXa
MYO9A
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91979 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14517 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti88L → R in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti94L → Q in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti104R → H in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti206H → R in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti394D → N in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti424S → P in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti504S → C in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti573E → D in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti595C → Y in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti694I → M in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti705L → I in CAA04947 (PubMed:9819351).Curated1
Sequence conflicti1591S → P in BAB14517 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04616537R → K1 PublicationCorresponds to variant dbSNP:rs17855105Ensembl.1
Natural variantiVAR_04616685R → Q1 Publication1
Natural variantiVAR_046167161T → I. Corresponds to variant dbSNP:rs2929516EnsemblClinVar.1
Natural variantiVAR_046168168N → D1 Publication1
Natural variantiVAR_081671203Y → C in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs374155761EnsemblClinVar.1
Natural variantiVAR_046169211L → P1 Publication1
Natural variantiVAR_082148513 – 2548Missing in CMS24; unknown pathological significance. 1 PublicationAdd BLAST2036
Natural variantiVAR_056189825A → V. Corresponds to variant dbSNP:rs11637562Ensembl.1
Natural variantiVAR_046170946R → Q1 PublicationCorresponds to variant dbSNP:rs754348944Ensembl.1
Natural variantiVAR_0461711193G → E4 PublicationsCorresponds to variant dbSNP:rs2415129Ensembl.1
Natural variantiVAR_0461721362S → P1 PublicationCorresponds to variant dbSNP:rs55738821Ensembl.1
Natural variantiVAR_0461731476P → R. Corresponds to variant dbSNP:rs16956375EnsemblClinVar.1
Natural variantiVAR_0816721517R → H in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149046541Ensembl.1
Natural variantiVAR_0816731698D → G in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs150726107Ensembl.1
Natural variantiVAR_0461741795H → Y. Corresponds to variant dbSNP:rs16956367EnsemblClinVar.1
Natural variantiVAR_0461751805H → Q. Corresponds to variant dbSNP:rs2306575Ensembl.1
Natural variantiVAR_0461761834R → C1 PublicationCorresponds to variant dbSNP:rs74475742Ensembl.1
Natural variantiVAR_0816742282G → E in CMS24; unknown pathological significance. 1 Publication1
Natural variantiVAR_0816752283R → H in CMS24; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs142345927EnsemblClinVar.1
Natural variantiVAR_0461772390I → V. Corresponds to variant dbSNP:rs2291280Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03515645 – 280Missing in isoform 5. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_035157367 – 385Missing in isoform 2. CuratedAdd BLAST19
Alternative sequenceiVSP_035158729H → K in isoform 3. 1 Publication1
Alternative sequenceiVSP_035159730 – 2548Missing in isoform 3. 1 PublicationAdd BLAST1819
Alternative sequenceiVSP_0351601714E → EVARPAHKKKARMARTRSDF LTRGTFADGEGDTEEDDYDD IIEPLLSLDQASHCELGPAP SLGQASHSDSEM in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF117888 mRNA Translation: AAD49195.1
AC020779 Genomic DNA No translation available.
AC022872 Genomic DNA No translation available.
AC090454 Genomic DNA No translation available.
AC104938 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77880.1
BC060886 mRNA Translation: AAH60886.1
BC140869 mRNA Translation: AAI40870.1
AJ001714 mRNA Translation: CAA04947.1
AB290183 mRNA Translation: BAG06737.1
L29148 mRNA Translation: AAA20911.1
DQ088983 mRNA Translation: AAZ85978.1
DQ088984 mRNA Translation: AAZ85979.1
AL137287 mRNA Translation: CAB70679.1
AK001923 mRNA Translation: BAA91979.1 Different initiation.
AK023306 mRNA Translation: BAB14517.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10239.1 [B2RTY4-1]

Protein sequence database of the Protein Information Resource

More...PIRi		E59435
I61699
T46354

NCBI Reference Sequences

More...RefSeqi		NP_008832.2, NM_006901.3 [B2RTY4-1]
XP_006720602.1, XM_006720539.2 [B2RTY4-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356056; ENSP00000348349; ENSG00000066933 [B2RTY4-1]
ENST00000424560; ENSP00000399162; ENSG00000066933 [B2RTY4-3]
ENST00000444904; ENSP00000398250; ENSG00000066933 [B2RTY4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4649

UCSC genome browser

More...UCSCi		uc002atl.6, human [B2RTY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117888 mRNA Translation: AAD49195.1
AC020779 Genomic DNA No translation available.
AC022872 Genomic DNA No translation available.
AC090454 Genomic DNA No translation available.
AC104938 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77880.1
BC060886 mRNA Translation: AAH60886.1
BC140869 mRNA Translation: AAI40870.1
AJ001714 mRNA Translation: CAA04947.1
AB290183 mRNA Translation: BAG06737.1
L29148 mRNA Translation: AAA20911.1
DQ088983 mRNA Translation: AAZ85978.1
DQ088984 mRNA Translation: AAZ85979.1
AL137287 mRNA Translation: CAB70679.1
AK001923 mRNA Translation: BAA91979.1 Different initiation.
AK023306 mRNA Translation: BAB14517.1 Different initiation.
CCDSiCCDS10239.1 [B2RTY4-1]
PIRiE59435
I61699
T46354
RefSeqiNP_008832.2, NM_006901.3 [B2RTY4-1]
XP_006720602.1, XM_006720539.2 [B2RTY4-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110733, 57 interactors
IntActiB2RTY4, 29 interactors
STRINGi9606.ENSP00000348349

PTM databases

iPTMnetiB2RTY4
PhosphoSitePlusiB2RTY4

Genetic variation databases

BioMutaiMYO9A

Proteomic databases

EPDiB2RTY4
jPOSTiB2RTY4
MassIVEiB2RTY4
MaxQBiB2RTY4
PaxDbiB2RTY4
PeptideAtlasiB2RTY4
PRIDEiB2RTY4
ProteomicsDBi3450 [B2RTY4-1]
3451 [B2RTY4-2]
3452 [B2RTY4-3]
3453 [B2RTY4-4]
3454 [B2RTY4-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26536, 29 antibodies

Genome annotation databases

EnsembliENST00000356056; ENSP00000348349; ENSG00000066933 [B2RTY4-1]
ENST00000424560; ENSP00000399162; ENSG00000066933 [B2RTY4-3]
ENST00000444904; ENSP00000398250; ENSG00000066933 [B2RTY4-1]
GeneIDi4649
KEGGihsa:4649
UCSCiuc002atl.6, human [B2RTY4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4649
DisGeNETi4649

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYO9A
GeneReviewsiMYO9A
HGNCiHGNC:7608, MYO9A
HPAiENSG00000066933, Low tissue specificity
MalaCardsiMYO9A
MIMi604875, gene
618198, phenotype
neXtProtiNX_B2RTY4
OpenTargetsiENSG00000066933
Orphaneti98914, Presynaptic congenital myasthenic syndromes
PharmGKBiPA31413
VEuPathDBiHostDB:ENSG00000066933.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1453, Eukaryota
KOG4229, Eukaryota
GeneTreeiENSGT00940000154905
HOGENOMiCLU_000192_7_5_1
InParanoidiB2RTY4
OMAiKYQAANM
OrthoDBi14881at2759
PhylomeDBiB2RTY4
TreeFamiTF316834

Enzyme and pathway databases

PathwayCommonsiB2RTY4
ReactomeiR-HSA-194840, Rho GTPase cycle
SIGNORiB2RTY4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4649, 10 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYO9A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4649
PharosiB2RTY4, Tdark

Protein Ontology

More...PROi		PR:B2RTY4
RNActiB2RTY4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000066933, Expressed in calcaneal tendon and 249 other tissues
ExpressionAtlasiB2RTY4, baseline and differential
GenevisibleiB2RTY4, HS

Family and domain databases

CDDicd00029, C1, 1 hit
cd01385, MYSc_Myo9, 1 hit
Gene3Di1.10.555.10, 1 hit
3.40.850.10, 2 hits
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR028558, MYO9A
IPR001609, Myosin_head_motor_dom
IPR036023, MYSc_Myo9
IPR027417, P-loop_NTPase
IPR002219, PE/DAG-bd
IPR000159, RA_dom
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR46184:SF3, PTHR46184:SF3, 2 hits
PfamiView protein in Pfam
PF00612, IQ, 4 hits
PF00063, Myosin_head, 2 hits
PF00788, RA, 1 hit
PF00620, RhoGAP, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00015, IQ, 5 hits
SM00242, MYSc, 1 hit
SM00314, RA, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
SSF52540, SSF52540, 2 hits
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 4 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS50200, RA, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO9A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RTY4
Secondary accession number(s): B0I1T5
, C9IYB3, C9JA86, Q14787, Q3YLD7, Q3YLD8, Q6P986, Q9H8T5, Q9NTG2, Q9NUY2, Q9UEP3, Q9UNJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again