UniProtKB - B2RTY4 (MYO9A_HUMAN)
Protein
Unconventional myosin-IXa
Gene
MYO9A
Organism
Homo sapiens (Human)
Status
Functioni
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons, has a role in the regulation of neuronal morphology and function.By similarity
Caution
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 239 – 246 | ATPSequence analysis | 8 | |
Zinc fingeri | 1999 – 2048 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 50 | |
Zinc fingeri | 2068 – 2119 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 52 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- ATP binding Source: UniProtKB-KW
- GTPase activator activity Source: Reactome
- metal ion binding Source: UniProtKB-KW
- motor activity Source: InterPro
GO - Biological processi
- bioluminescence Source: UniProtKB-KW
- cell junction assembly Source: UniProtKB
- establishment of epithelial cell apical/basal polarity Source: UniProtKB
- intracellular signal transduction Source: InterPro
- regulation of small GTPase mediated signal transduction Source: Reactome
- visual perception Source: ProtInc
Keywordsi
Molecular function | Actin-binding, GTPase activation, Motor protein, Myosin, Photoprotein |
Biological process | Luminescence |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-194840 Rho GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-IXaAlternative name(s): Unconventional myosin-9a |
Gene namesi | Name:MYO9A Synonyms:MYR7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000066933.15 |
HGNCi | HGNC:7608 MYO9A |
MIMi | 604875 gene |
neXtProti | NX_B2RTY4 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass membrane protein By similarity
- Cytoplasm By similarity
Note: Localized in the cytoplasm of cell bodies, dendrites and axons with occasional hints of an enrichment near the plasma membrane.By similarity
Cytoskeleton
- unconventional myosin complex Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 175 – 195 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
GeneReviewsi | MYO9A |
MalaCardsi | MYO9A |
OpenTargetsi | ENSG00000066933 |
Orphaneti | 98914 Presynaptic congenital myasthenic syndromes |
PharmGKBi | PA31413 |
Polymorphism and mutation databases
BioMutai | MYO9A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000348440 | 1 – 2548 | Unconventional myosin-IXaAdd BLAST | 2548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 755 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1242 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1258 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1299 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1364 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1948 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2294 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2464 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by ALPK1 following monosodium urate monohydrate (MSU)-induced inflammation.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | B2RTY4 |
jPOSTi | B2RTY4 |
MaxQBi | B2RTY4 |
PaxDbi | B2RTY4 |
PRIDEi | B2RTY4 |
ProteomicsDBi | 3450 3451 [B2RTY4-2] 3452 [B2RTY4-3] 3453 [B2RTY4-4] 3454 [B2RTY4-5] |
PTM databases
iPTMneti | B2RTY4 |
PhosphoSitePlusi | B2RTY4 |
Expressioni
Tissue specificityi
Found to be expressed in testis and placenta, and at lower levels in all the examined tissues with the exception of liver (PubMed:10409426). Isoform 5: Found in leukocytes but not in brain, retina or testis (PubMed:10409426).1 Publication
Gene expression databases
Bgeei | ENSG00000066933 Expressed in 236 organ(s), highest expression level in stomach |
ExpressionAtlasi | B2RTY4 baseline and differential |
Genevisiblei | B2RTY4 HS |
Organism-specific databases
HPAi | HPA039812 HPA040071 |
Interactioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGridi | 110733, 34 interactors |
IntActi | B2RTY4, 10 interactors |
STRINGi | 9606.ENSP00000348349 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 112 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 146 – 1016 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 871 | |
Domaini | 1021 – 1041 | IQ 1PROSITE-ProRule annotationAdd BLAST | 21 | |
Domaini | 1042 – 1071 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1074 – 1103 | IQ 3PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1115 – 1144 | IQ 4PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1138 – 1167 | IQ 5PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 2063 – 2251 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 189 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 907 – 918 | Actin-bindingBy similarityAdd BLAST | 12 | |
Regioni | 1021 – 1162 | Neck or regulatory domainAdd BLAST | 142 | |
Regioni | 1163 – 2511 | TailAdd BLAST | 1349 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1264 – 1291 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 1486 – 1532 | Sequence analysisAdd BLAST | 47 | |
Coiled coili | 2315 – 2358 | Sequence analysisAdd BLAST | 44 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1999 – 2048 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 50 | |
Zinc fingeri | 2068 – 2119 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 52 |
Keywords - Domaini
Coiled coil, Repeat, Transmembrane, Transmembrane helix, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1453 Eukaryota KOG4229 Eukaryota COG5022 LUCA |
GeneTreei | ENSGT00940000154905 |
HOVERGENi | HBG108165 |
InParanoidi | B2RTY4 |
KOi | K10360 |
OMAi | KPRIGEC |
OrthoDBi | 14881at2759 |
PhylomeDBi | B2RTY4 |
TreeFami | TF316834 |
Family and domain databases
CDDi | cd00029 C1, 1 hit cd01385 MYSc_Myo9, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 3.40.850.10, 2 hits |
InterProi | View protein in InterPro IPR000048 IQ_motif_EF-hand-BS IPR036961 Kinesin_motor_dom_sf IPR028558 MYO9A IPR001609 Myosin_head_motor_dom IPR036023 MYSc_Myo9 IPR027417 P-loop_NTPase IPR002219 PE/DAG-bd IPR000159 RA_dom IPR008936 Rho_GTPase_activation_prot IPR000198 RhoGAP_dom IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR13140:SF9 PTHR13140:SF9, 2 hits |
Pfami | View protein in Pfam PF00612 IQ, 4 hits PF00063 Myosin_head, 2 hits PF00788 RA, 1 hit PF00620 RhoGAP, 1 hit |
PRINTSi | PR00193 MYOSINHEAVY |
SMARTi | View protein in SMART SM00109 C1, 1 hit SM00015 IQ, 5 hits SM00242 MYSc, 1 hit SM00314 RA, 1 hit SM00324 RhoGAP, 1 hit |
SUPFAMi | SSF48350 SSF48350, 1 hit SSF52540 SSF52540, 2 hits SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50096 IQ, 4 hits PS51456 MYOSIN_MOTOR, 1 hit PS50200 RA, 1 hit PS50238 RHOGAP, 1 hit PS00479 ZF_DAG_PE_1, 1 hit PS50081 ZF_DAG_PE_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: B2RTY4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNINDGGRRR FEDNEHTLRI YPGAISEGTI YCPIPARKNS TAAEVIESLI
60 70 80 90 100
NKLHLDKTKC YVLAEVKEFG GEEWILNPTD CPVQRMMLWP RMALENRLSG
110 120 130 140 150
EDYRFLLREK NLDGSIHYGS LQSWLRVTEE RRRMMERGFL PQPQQKDFDD
160 170 180 190 200
LCSLPDLNEK TLLENLRNRF KHEKIYTYVG SILIVINPFK FLPIYNPKYV
210 220 230 240 250
KMYDNHQLGK LEPHIYAVAD VAYHAMLQRK KNQCIVISGE SGSGKTQSTN
260 270 280 290 300
FLIHHLTALS QKGFASGVEQ IILGAGPVLE AFGNAKTAHN NNSSRFGKFI
310 320 330 340 350
QVNYQETGTV LGAYVEKYLL EKSRLVYQEH NERNYHVFYY LLAGASEDER
360 370 380 390 400
SAFHLKQPEE YHYLNQITKK PLRQSWDDYC YDSEPDCFTV EGEDLRHDFE
410 420 430 440 450
RLQLAMEMVG FLPKTRRQIF SLLSAILHLG NICYKKKTYR DDSIDICNPE
460 470 480 490 500
VLPIVSELLE VKEEMLFEAL VTRKTVTVGE KLILPYKLAE AVTVRNSMAK
510 520 530 540 550
SLYSALFDWI VFRINHALLN SKDLEHNTKT LSIGVLDIFG FEDYENNSFE
560 570 580 590 600
QFCINFANER LQHYFNQHIF KLEQEEYRTE GISWHNIDYI DNTCCINLIS
610 620 630 640 650
KKPTGLLHLL DEESNFPQAT NQTLLDKFKH QHEDNSYIEF PAVMEPAFII
660 670 680 690 700
KHYAGKVKYG VKDFREKNTD HMRPDIVALL RSSKNAFISG MIGIDPVAVF
710 720 730 740 750
RWAILRAFFR AMVAFREAGK RNIHRKTGHD DTAPCAILKS MDSFSFLQHP
760 770 780 790 800
VHQRSLEILQ RCKEEKYSIT RKNPRTPLSD LQGMNALNEK NQHDTFDIAW
810 820 830 840 850
NGRTGIRQSR LSSGTSLLDK DGIFANSTSS KLLERAHGIL TRNKNFKSKP
860 870 880 890 900
ALPKHLLEVN SLKHLTRLTL QDRITKSLLH LHKKKKPPSI SAQFQASLSK
910 920 930 940 950
LMETLGQAEP YFVKCIRSNA EKLPLRFSDV LVLRQLRYTG MLETVRIRQS
960 970 980 990 1000
GYSSKYSFQD FVSHFHVLLP RNIIPSKFNI QDFFRKINLN PDNYQVGKTM
1010 1020 1030 1040 1050
VFLKEQERQH LQDLLHQEVL RRIILLQRWF RVLLCRQHFL HLRQASVIIQ
1060 1070 1080 1090 1100
RFWRNYLNQK QVRDAAVQKD AFVMASAAAL LQASWRAHLE RQRYLELRAA
1110 1120 1130 1140 1150
AIVIQQKWRD YYRRRHMAAI CIQARWKAYR ESKRYQEQRK KIILLQSTCR
1160 1170 1180 1190 1200
GFRARQRFKA LKEQRLRETK PEVGLVNIKG YGSLEIQGSD PSGWEDCSFD
1210 1220 1230 1240 1250
NRIKAIEECK SVIESNRISR ESSVDCLKES PNKQQERAQS QSGVDLQEDV
1260 1270 1280 1290 1300
LVRERPRSLE DLHQKKVGRA KRESRRMREL EQAIFSLELL KVRSLGGISP
1310 1320 1330 1340 1350
SEDRRWSTEL VPEGLQSPRG TPDSESSQGS LELLSYEESQ KSKLESVISD
1360 1370 1380 1390 1400
EGDLQFPSPK ISSSPKFDSR DNALSASNET SSAEHLKDGT MKEMVVCSSE
1410 1420 1430 1440 1450
SITCKPQLKD SFISNSLPTF FYIPQQDPLK TNSQLDTSIQ RNKLLENEDT
1460 1470 1480 1490 1500
AGEALTLDIN RETRRYHCSG KDQIVPSLNT ESSNPVLKKL EKLNTEKEER
1510 1520 1530 1540 1550
QKQLQQQNEK EMMEQIRQQT DILEKERKAF KTIEKPRIGE CLVAPSSYQS
1560 1570 1580 1590 1600
KQRVERPSSL LSLNTSNKGE LNVLGSLSLK DAALAQKDSS SAHLPPKDRP
1610 1620 1630 1640 1650
VTVFFERKGS PCQSSTVKEL SKTDRMGTQL NVACKLSNNR ISKREHFRPT
1660 1670 1680 1690 1700
QSYSHNSDDL SREGNARPIF FTPKDNMSIP LVSKEALNSK NPQLHKEDEP
1710 1720 1730 1740 1750
AWKPVKLAGP GQRETSQRFS SVDEQAKLHK TMSQGEITKL AVRQKASDSD
1760 1770 1780 1790 1800
IRPQRAKMRF WAKGKQGEKK TTRVKPTTQS EVSPLFAGTD VIPAHQFPDE
1810 1820 1830 1840 1850
LAAYHPTPPL SPELPGSCRK EFKENKEPSP KAKRKRSVKI SNVALDSMHW
1860 1870 1880 1890 1900
QNDSVQIIAS VSDLKSMDEF LLKKVNDLDN EDSKKDTLVD VVFKKALKEF
1910 1920 1930 1940 1950
RQNIFSFYSS ALAMDDGKSI RYKDLYALFE QILEKTMRLE QRDSLGESPV
1960 1970 1980 1990 2000
RVWVNTFKVF LDEYMNEFKT SDCTATKVPK TERKKRRKKE TDLVEEHNGH
2010 2020 2030 2040 2050
IFKATQYSIP TYCEYCSSLI WIMDRASVCK LCKYACHKKC CLKTTAKCSK
2060 2070 2080 2090 2100
KYDPELSSRQ FGVELSRLTS EDRTVPLVVE KLINYIEMHG LYTEGIYRKS
2110 2120 2130 2140 2150
GSTNKIKELR QGLDTDAESV NLDDYNIHVI ASVFKQWLRD LPNPLMTFEL
2160 2170 2180 2190 2200
YEEFLRAMGL QERKETIRGV YSVIDQLSRT HLNTLERLIF HLVRIALQED
2210 2220 2230 2240 2250
TNRMSANALA IVFAPCILRC PDTTDPLQSV QDISKTTTCV ELIVVEQMNK
2260 2270 2280 2290 2300
YKARLKDISS LEFAENKAKT RLSLIRRSMG KGRIRRGNYP GPSSPVVVRL
2310 2320 2330 2340 2350
PSVSDVSEET LTSEAAMETD ITEQQQAAMQ QEERVLTEQI ENLQKEKEEL
2360 2370 2380 2390 2400
TFEMLVLEPR ASDDETLESE ASIGTADSSE NLNMESEYAI SEKSERSLAL
2410 2420 2430 2440 2450
SSLKTAGKSE PSSKLRKQLK KQQDSLDVVD SSVSSLCLSN TASSHGTRKL
2460 2470 2480 2490 2500
FQIYSKSPFY RAASGNEALG MEGPLGQTKF LEDKPQFISR GTFNPEKGKQ
2510 2520 2530 2540
KLKNVKNSPQ KTKETPEGTV MSGRRKTVDP DCTSNQQLAL FGNNEFMV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRD5 | H3BRD5_HUMAN | Unconventional myosin-IXa | MYO9A | 2,396 | Annotation score: | ||
H3BMM1 | H3BMM1_HUMAN | Unconventional myosin-IXa | MYO9A | 1,301 | Annotation score: | ||
H3BTL9 | H3BTL9_HUMAN | Unconventional myosin-IXa | MYO9A | 90 | Annotation score: | ||
H3BV44 | H3BV44_HUMAN | Unconventional myosin-IXa | MYO9A | 1,398 | Annotation score: | ||
H3BU05 | H3BU05_HUMAN | Unconventional myosin-IXa | MYO9A | 463 | Annotation score: | ||
H3BP49 | H3BP49_HUMAN | Unconventional myosin-IXa | MYO9A | 194 | Annotation score: | ||
H3BMS3 | H3BMS3_HUMAN | Unconventional myosin-IXa | MYO9A | 140 | Annotation score: | ||
H3BSU8 | H3BSU8_HUMAN | Unconventional myosin-IXa | MYO9A | 73 | Annotation score: |
Sequence cautioni
The sequence BAA91979 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14517 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 88 | L → R in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 94 | L → Q in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 104 | R → H in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 206 | H → R in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 394 | D → N in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 424 | S → P in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 504 | S → C in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 573 | E → D in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 595 | C → Y in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 694 | I → M in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 705 | L → I in CAA04947 (PubMed:9819351).Curated | 1 | |
Sequence conflicti | 1591 | S → P in BAB14517 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046165 | 37 | R → K1 PublicationCorresponds to variant dbSNP:rs17855105Ensembl. | 1 | |
Natural variantiVAR_046166 | 85 | R → Q1 Publication | 1 | |
Natural variantiVAR_046167 | 161 | T → I. Corresponds to variant dbSNP:rs2929516Ensembl. | 1 | |
Natural variantiVAR_046168 | 168 | N → D1 Publication | 1 | |
Natural variantiVAR_046169 | 211 | L → P1 Publication | 1 | |
Natural variantiVAR_056189 | 825 | A → V. Corresponds to variant dbSNP:rs11637562Ensembl. | 1 | |
Natural variantiVAR_046170 | 946 | R → Q1 PublicationCorresponds to variant dbSNP:rs754348944Ensembl. | 1 | |
Natural variantiVAR_046171 | 1193 | G → E4 PublicationsCorresponds to variant dbSNP:rs2415129Ensembl. | 1 | |
Natural variantiVAR_046172 | 1362 | S → P1 PublicationCorresponds to variant dbSNP:rs55738821Ensembl. | 1 | |
Natural variantiVAR_046173 | 1476 | P → R. Corresponds to variant dbSNP:rs16956375Ensembl. | 1 | |
Natural variantiVAR_046174 | 1795 | H → Y. Corresponds to variant dbSNP:rs16956367Ensembl. | 1 | |
Natural variantiVAR_046175 | 1805 | H → Q. Corresponds to variant dbSNP:rs2306575Ensembl. | 1 | |
Natural variantiVAR_046176 | 1834 | R → C1 PublicationCorresponds to variant dbSNP:rs74475742Ensembl. | 1 | |
Natural variantiVAR_046177 | 2390 | I → V. Corresponds to variant dbSNP:rs2291280Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035156 | 45 – 280 | Missing in isoform 5. 1 PublicationAdd BLAST | 236 | |
Alternative sequenceiVSP_035157 | 367 – 385 | Missing in isoform 2. CuratedAdd BLAST | 19 | |
Alternative sequenceiVSP_035158 | 729 | H → K in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_035159 | 730 – 2548 | Missing in isoform 3. 1 PublicationAdd BLAST | 1819 | |
Alternative sequenceiVSP_035160 | 1714 | E → EVARPAHKKKARMARTRSDF LTRGTFADGEGDTEEDDYDD IIEPLLSLDQASHCELGPAP SLGQASHSDSEM in isoform 4. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117888 mRNA Translation: AAD49195.1 AC020779 Genomic DNA No translation available. AC022872 Genomic DNA No translation available. AC090454 Genomic DNA No translation available. AC104938 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77880.1 BC060886 mRNA Translation: AAH60886.1 BC140869 mRNA Translation: AAI40870.1 AJ001714 mRNA Translation: CAA04947.1 AB290183 mRNA Translation: BAG06737.1 L29148 mRNA Translation: AAA20911.1 DQ088983 mRNA Translation: AAZ85978.1 DQ088984 mRNA Translation: AAZ85979.1 AL137287 mRNA Translation: CAB70679.1 AK001923 mRNA Translation: BAA91979.1 Different initiation. AK023306 mRNA Translation: BAB14517.1 Different initiation. |
CCDSi | CCDS10239.1 [B2RTY4-1] |
PIRi | E59435 I61699 T46354 |
RefSeqi | NP_008832.2, NM_006901.3 [B2RTY4-1] XP_006720602.1, XM_006720539.2 [B2RTY4-4] |
UniGenei | Hs.513000 Hs.546268 Hs.733087 |
Genome annotation databases
Ensembli | ENST00000356056; ENSP00000348349; ENSG00000066933 [B2RTY4-1] ENST00000424560; ENSP00000399162; ENSG00000066933 [B2RTY4-3] ENST00000444904; ENSP00000398250; ENSG00000066933 [B2RTY4-1] |
GeneIDi | 4649 |
KEGGi | hsa:4649 |
UCSCi | uc002atl.6 human [B2RTY4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF117888 mRNA Translation: AAD49195.1 AC020779 Genomic DNA No translation available. AC022872 Genomic DNA No translation available. AC090454 Genomic DNA No translation available. AC104938 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77880.1 BC060886 mRNA Translation: AAH60886.1 BC140869 mRNA Translation: AAI40870.1 AJ001714 mRNA Translation: CAA04947.1 AB290183 mRNA Translation: BAG06737.1 L29148 mRNA Translation: AAA20911.1 DQ088983 mRNA Translation: AAZ85978.1 DQ088984 mRNA Translation: AAZ85979.1 AL137287 mRNA Translation: CAB70679.1 AK001923 mRNA Translation: BAA91979.1 Different initiation. AK023306 mRNA Translation: BAB14517.1 Different initiation. |
CCDSi | CCDS10239.1 [B2RTY4-1] |
PIRi | E59435 I61699 T46354 |
RefSeqi | NP_008832.2, NM_006901.3 [B2RTY4-1] XP_006720602.1, XM_006720539.2 [B2RTY4-4] |
UniGenei | Hs.513000 Hs.546268 Hs.733087 |
3D structure databases
ProteinModelPortali | B2RTY4 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 110733, 34 interactors |
IntActi | B2RTY4, 10 interactors |
STRINGi | 9606.ENSP00000348349 |
PTM databases
iPTMneti | B2RTY4 |
PhosphoSitePlusi | B2RTY4 |
Polymorphism and mutation databases
BioMutai | MYO9A |
Proteomic databases
EPDi | B2RTY4 |
jPOSTi | B2RTY4 |
MaxQBi | B2RTY4 |
PaxDbi | B2RTY4 |
PRIDEi | B2RTY4 |
ProteomicsDBi | 3450 3451 [B2RTY4-2] 3452 [B2RTY4-3] 3453 [B2RTY4-4] 3454 [B2RTY4-5] |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000356056; ENSP00000348349; ENSG00000066933 [B2RTY4-1] ENST00000424560; ENSP00000399162; ENSG00000066933 [B2RTY4-3] ENST00000444904; ENSP00000398250; ENSG00000066933 [B2RTY4-1] |
GeneIDi | 4649 |
KEGGi | hsa:4649 |
UCSCi | uc002atl.6 human [B2RTY4-1] |
Organism-specific databases
CTDi | 4649 |
EuPathDBi | HostDB:ENSG00000066933.15 |
GeneCardsi | MYO9A |
GeneReviewsi | MYO9A |
H-InvDBi | HIX0012401 |
HGNCi | HGNC:7608 MYO9A |
HPAi | HPA039812 HPA040071 |
MalaCardsi | MYO9A |
MIMi | 604875 gene |
neXtProti | NX_B2RTY4 |
OpenTargetsi | ENSG00000066933 |
Orphaneti | 98914 Presynaptic congenital myasthenic syndromes |
PharmGKBi | PA31413 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1453 Eukaryota KOG4229 Eukaryota COG5022 LUCA |
GeneTreei | ENSGT00940000154905 |
HOVERGENi | HBG108165 |
InParanoidi | B2RTY4 |
KOi | K10360 |
OMAi | KPRIGEC |
OrthoDBi | 14881at2759 |
PhylomeDBi | B2RTY4 |
TreeFami | TF316834 |
Enzyme and pathway databases
Reactomei | R-HSA-194840 Rho GTPase cycle |
Miscellaneous databases
ChiTaRSi | MYO9A human |
GenomeRNAii | 4649 |
PROi | PR:B2RTY4 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000066933 Expressed in 236 organ(s), highest expression level in stomach |
ExpressionAtlasi | B2RTY4 baseline and differential |
Genevisiblei | B2RTY4 HS |
Family and domain databases
CDDi | cd00029 C1, 1 hit cd01385 MYSc_Myo9, 1 hit |
Gene3Di | 1.10.555.10, 1 hit 3.40.850.10, 2 hits |
InterProi | View protein in InterPro IPR000048 IQ_motif_EF-hand-BS IPR036961 Kinesin_motor_dom_sf IPR028558 MYO9A IPR001609 Myosin_head_motor_dom IPR036023 MYSc_Myo9 IPR027417 P-loop_NTPase IPR002219 PE/DAG-bd IPR000159 RA_dom IPR008936 Rho_GTPase_activation_prot IPR000198 RhoGAP_dom IPR029071 Ubiquitin-like_domsf |
PANTHERi | PTHR13140:SF9 PTHR13140:SF9, 2 hits |
Pfami | View protein in Pfam PF00612 IQ, 4 hits PF00063 Myosin_head, 2 hits PF00788 RA, 1 hit PF00620 RhoGAP, 1 hit |
PRINTSi | PR00193 MYOSINHEAVY |
SMARTi | View protein in SMART SM00109 C1, 1 hit SM00015 IQ, 5 hits SM00242 MYSc, 1 hit SM00314 RA, 1 hit SM00324 RhoGAP, 1 hit |
SUPFAMi | SSF48350 SSF48350, 1 hit SSF52540 SSF52540, 2 hits SSF54236 SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50096 IQ, 4 hits PS51456 MYOSIN_MOTOR, 1 hit PS50200 RA, 1 hit PS50238 RHOGAP, 1 hit PS00479 ZF_DAG_PE_1, 1 hit PS50081 ZF_DAG_PE_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | MYO9A_HUMAN | |
Accessioni | B2RTY4Primary (citable) accession number: B2RTY4 Secondary accession number(s): B0I1T5 Q9UNJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 13, 2019 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations