UniProtKB - B2RTQ2 (B2RTQ2_HUMAN)
Protein
Submitted name:
TBC1 domain family, member 2B, isoform CRA_b
Gene
TBC1D2B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: TBC1 domain family, member 2B, isoform CRA_bImportedSubmitted name: TBC1D2B proteinImported |
Gene namesi | Name:TBC1D2BImported ORF Names:hCG_38935Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 536 – 730 | Rab-GAP TBCInterPro annotationAdd BLAST | 195 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 146 – 222 | DisorderedSequence analysisAdd BLAST | 77 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 279 – 313 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 353 – 408 | Sequence analysisAdd BLAST | 56 | |
Coiled coili | 799 – 819 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 188 – 222 | PolarSequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OrthoDBi | 1162786at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RTQ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTYWLQELQQ KRWEYCNSLD MVKWDSRTSP TPGDFPKGLV ARDNTDLIYP
60 70 80 90 100
HPNASAEKAR NVLAVETVPG ELVGEQAANQ PAPGHPNSIN FYSLKQWGNE
110 120 130 140 150
LKNSMSSFRP GRGHNDSRRT VFYTNEEWEL LDPTPKDLEE SIVQEEKKKL
160 170 180 190 200
TPEGNKGVTG SGFPFDFGRN PYKGKRPLKD IIGSYKNRHS SGDPSSEGTS
210 220 230 240 250
GSGSVSIRKP ASEMQLQVQS QQEELEQLKK DLSSQKELVR LLQQTVRSSQ
260 270 280 290 300
YDKYFTSSRL CEGVPKDTLE LLHQKDDQIL GLTSQLERFS LEKESLQQEV
310 320 330 340 350
RTLKSKVGEL NEQLGMLMET IQAKDEVIIK LSEGEGNGPP PTVAPSSPSV
360 370 380 390 400
VPVARDQLEL DRLKDNLQGY KTQNKFLNKE ILELSALRRN AERRERDLMA
410 420 430 440 450
KYSSLEAKLC QIESKYLILL QEMKTPVCSE DQGPTREVIA QLLEDALQVE
460 470 480 490 500
SQEQPEQAFV KPHLVSEYDI YGFRTVPEDD EEEKLVAKVR ALDLKTLYLT
510 520 530 540 550
ENQEVSTGVK WENYFASTVN REMMCSPELK NLIRAGIPHE HRSKVWKWCV
560 570 580 590 600
DRHTRKFKDN TEPGHFQTLL QKALEKQNPA SKQIELDLLR TLPNNKHYSC
610 620 630 640 650
PTSEGIQKLR NVLLAFSWRN PDIGYCQGLN RLVAVALLYL EQEDAFWCLV
660 670 680 690 700
TIVEVFMPRD YYTKTLLGSQ VDQRVFRDLM SEKLPRLHGH FEQYKVDYTL
710 720 730 740 750
ITFNWFLVVF VDSVVSDILF KIWDSFLYEG PKVIFRFALA LFKYKEEEIL
760 770 780 790 800
KLQDSMSIFK YLRYFTRTIL DARKLISISF GDLNPFPLRQ IRNRRAYHLE
810 820 830
KVRLELTELE AIREDFLRER DTSPDKGELV SDEEEDT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC140766 mRNA Translation: AAI40767.1 CH471136 Genomic DNA Translation: EAW99189.1 |
RefSeqi | NP_653173.1, NM_144572.1 |
Genome annotation databases
GeneIDi | 23102 |
KEGGi | hsa:23102 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC140766 mRNA Translation: AAI40767.1 CH471136 Genomic DNA Translation: EAW99189.1 |
RefSeqi | NP_653173.1, NM_144572.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B2RTQ2 |
Genome annotation databases
GeneIDi | 23102 |
KEGGi | hsa:23102 |
Organism-specific databases
CTDi | 23102 |
PharmGKBi | PA142670832 |
Phylogenomic databases
OrthoDBi | 1162786at2759 |
Miscellaneous databases
BioGRID-ORCSi | 23102, 3 hits in 870 CRISPR screens |
ChiTaRSi | TBC1D2B, human |
GenomeRNAii | 23102 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RTQ2_HUMAN | |
Accessioni | B2RTQ2Primary (citable) accession number: B2RTQ2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | February 10, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |