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Protein

UDP-glucuronosyltransferase

Gene

Ugt1a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588 Glucuronidation
R-MMU-189483 Heme degradation

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:Ugt1a5Imported
ORF Names:mCG_14318Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3032634 Ugt1a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei487 – 510HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501501938825 – 529UDP-glucuronosyltransferaseUniRule annotationAdd BLAST505

Expressioni

Gene expression databases

BgeeiENSMUSG00000089943 Expressed in 12 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095263

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 393UDPGTInterPro annotationAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili409 – 429Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220832
HOVERGENiHBG004033
KOiK00699
OMAiIHRSCVE
OrthoDBiEOG091G03YY
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

B2RT14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLRMPLQGL VGLLLLCALP WTEGEKVLVF PVGGSHWLSM RDVVRELHAQ
60 70 80 90 100
GHQTVVLAPE VNMRIKEEDF FTFKVYAVPY TRQELEEMME NLKVFFDTGN
110 120 130 140 150
YMKKIFKTSE ALRNMSTVLL KTCTNILHNE SLLHHLNSSS FDVVFTDPVF
160 170 180 190 200
PCGALLAKYL GIPAVFFLRY IPCGIEYEAT QCPSPSSYIP NLFTRLSDHM
210 220 230 240 250
DFLQRVQNML YHLVLKYICH LLITPYESLA SELFQREVSS VELFSYASVW
260 270 280 290 300
LFRGDFVLDY PRPIMPNMVF IGGINCVTKK PLSQEFEAYV NASGEHGIVV
310 320 330 340 350
FSLGSMVSEI PEKKAMEIAE ALGRIPQTVL WRYTGTRPSN LAKNTILVKW
360 370 380 390 400
LPQNDLLGHP KTRAFITHSG SHGIYEGICN GVPMVMMPLF GDQMDNAKRM
410 420 430 440 450
ETRGAGVTLN VLEMTADDLE NALKTVINNK SYKENIMRLS SLHKDRPIEP
460 470 480 490 500
LDLAVFWVEY VMRHKGAPHL RPAAHDLTWY QYHSLDVIGF LLAIVLTVVF
510 520
IVFKCCAYGC RKCFGGKGRV KKSHKSKTH
Length:529
Mass (Da):60,073
Last modified:July 1, 2008 - v1
Checksum:iACA1EADA382CCE4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087780 Genomic DNA No translation available.
AC087801 Genomic DNA No translation available.
BC139093 mRNA Translation: AAI39094.1
BC139094 mRNA Translation: AAI39095.1
CH466520 Genomic DNA Translation: EDL40128.1
RefSeqiNP_964005.2, NM_201643.2
UniGeneiMm.300095

Genome annotation databases

EnsembliENSMUST00000097659; ENSMUSP00000095263; ENSMUSG00000089943
GeneIDi394433
KEGGimmu:394433
UCSCiuc007byh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087780 Genomic DNA No translation available.
AC087801 Genomic DNA No translation available.
BC139093 mRNA Translation: AAI39094.1
BC139094 mRNA Translation: AAI39095.1
CH466520 Genomic DNA Translation: EDL40128.1
RefSeqiNP_964005.2, NM_201643.2
UniGeneiMm.300095

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095263

Protocols and materials databases

DNASUi394433
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097659; ENSMUSP00000095263; ENSMUSG00000089943
GeneIDi394433
KEGGimmu:394433
UCSCiuc007byh.1 mouse

Organism-specific databases

CTDi54579
MGIiMGI:3032634 Ugt1a5

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220832
HOVERGENiHBG004033
KOiK00699
OMAiIHRSCVE
OrthoDBiEOG091G03YY
TreeFamiTF315472

Enzyme and pathway databases

ReactomeiR-MMU-156588 Glucuronidation
R-MMU-189483 Heme degradation

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089943 Expressed in 12 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RT14_MOUSE
AccessioniPrimary (citable) accession number: B2RT14
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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