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Entry version 84 (16 Jan 2019)
Sequence version 1 (01 Jul 2008)
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Protein
Submitted name:

Cingulin-like 1

Gene

Cgnl1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cingulin-like 1Imported
Submitted name:
Cingulin-like protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cgnl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915428 Cgnl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032232 Expressed in 271 organ(s), highest expression level in heart

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini607 – 1032Myosin_tail_1InterPro annotationAdd BLAST426
Domaini1020 – 1251Myosin_tail_1InterPro annotationAdd BLAST232

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili612 – 716Sequence analysisAdd BLAST105
Coiled coili725 – 805Sequence analysisAdd BLAST81
Coiled coili820 – 962Sequence analysisAdd BLAST143
Coiled coili975 – 1044Sequence analysisAdd BLAST70
Coiled coili1052 – 1086Sequence analysisAdd BLAST35
Coiled coili1091 – 1128Sequence analysisAdd BLAST38
Coiled coili1137 – 1185Sequence analysisAdd BLAST49
Coiled coili1190 – 1245Sequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGSJ Eukaryota
ENOG410YEC7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154489

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107670

KEGG Orthology (KO)

More...
KOi
K21110

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTCFPKP

Database of Orthologous Groups

More...
OrthoDBi
110948at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332247

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002928 Myosin_tail

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01576 Myosin_tail_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B2RSU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELYFGEYQH VQQEYGVHLR LASGDTPKPR NSQPSKAGSY GVSIRVQGID
60 70 80 90 100
GHPYIVLNNT ERCLAGTPFP ENAPSFPSSV INNLSLHPSN GTVLKENTPE
110 120 130 140 150
ELQLPENPYL QTSPLRGQKQ FSLHEGRNGV LERKDGPTKL PHVLNFQRHP
160 170 180 190 200
ELLQPYDPEK NEVNAKKHHP PESPWLRNAT EDGTNCKKSR NCFPKSYGSQ
210 220 230 240 250
PNSPTSEDLA KTNMTAIRLC SSVVIEDPQK QTSVCVNVQR CAKEGVGEET
260 270 280 290 300
LSPRRKSPTA PSPQAYSETK KNRPDVLPFR RQDSAGPILD GARSRRSSSS
310 320 330 340 350
STTPTSATSL YKFLLDDQEC AIHADSVNRH ENRRYIPFLP GTGRDIDTCS
360 370 380 390 400
IPGVDQLIEK FDQKPGLQRR GRSGKRNRIN PDDRKRSRSV DSAFPFGLQG
410 420 430 440 450
NTEYLTEFSR NLGKSSEHLL RPSQVFPQRS VAQEHRGKHS PSSPPAKLQG
460 470 480 490 500
AQGAHPKPPL QNKDGKVLNK GRQESTGACA PSLPAPNKKE EEIKIATATL
510 520 530 540 550
MLQNRAVAAT SDSGAKKISV KTFPSDSSTQ ATPDLLKGQQ ELTQQTNEET
560 570 580 590 600
AKQILYNYLK EGGTDNEDAT KRKVNLVFEK IQTLKSRAAG SAQGSNQAPN
610 620 630 640 650
SPSEGNSLLD QKNKLILEVS ELQQQLQLEM KNQQNIKEER ERMREDLEEL
660 670 680 690 700
RVRHQSQVEE TATLQRRLEE SEGELRKSLE ELFQVKMERE QHQTEIRDLQ
710 720 730 740 750
DQLSEMHDEL DSTKRSEDRE KGALIEELLQ AKQDLQDLLI AKEEQEDLLR
760 770 780 790 800
KRERELTALK GALKEEVSSH DQEMDKLKEQ YDAELQALRE SVEEATKNVE
810 820 830 840 850
VLASRSNSSE QSQAEADLRE KVLKEENEKL QGRIAELERR AAQLQRQMED
860 870 880 890 900
VKGDEAQAKE TLRKCESEVQ QLEEALVHAR KEEKEATCAR RALEKELEQA
910 920 930 940 950
RRELSQVSQE QKELLEKLRD EAEQKEQLRK LKNEMESERW HLDKTIEKLQ
960 970 980 990 1000
KEMADIAEAS RTSSLELQKQ LGEYKEKNRR ELAEMQTQLK EKCLEVEKAR
1010 1020 1030 1040 1050
LAASKMQDEL RLKEEELQDY QRAEEEALTK RQLLEQSLKD LEYELEAKSH
1060 1070 1080 1090 1100
LKDDRSRLIK QMEDKVSQLE IELEEERTNA DLLSERITWS REQMEQMRSE
1110 1120 1130 1140 1150
LLQEKAAKQD LECDKISLER QNKDLKSRII HLEGSYRSSK EGLVVQMEAR
1160 1170 1180 1190 1200
IAELEDRLEN EERDRANLQL SNRRLERKVK ELVMQVDDEH LSLTDQKDQL
1210 1220 1230 1240 1250
SLRLKAMKRQ VEEAEEEIDR LESSKKKLQR ELEEQMGVNE QLQGQLNSLK
1260 1270 1280 1290
KGLRLKTLSS KVLDDSDDDD LSSDAGSLYE APLSYAFPKD STIASQI
Length:1,297
Mass (Da):148,169
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61146C36F92562F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6AW69CGNL1_MOUSE
Cingulin-like protein 1
Cgnl1 Jacop, Kiaa1749
1,298Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3H4D3Z3H4_MOUSE
Cingulin-like protein 1
Cgnl1
1,226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC093483 Genomic DNA No translation available.
AC107662 Genomic DNA No translation available.
BC139006 mRNA Translation: AAI39007.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291291.1, NM_001304362.1
NP_080875.3, NM_026599.5
XP_006511458.1, XM_006511395.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.99961

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000072899; ENSMUSP00000072672; ENSMUSG00000032232
ENSMUST00000122065; ENSMUSP00000112479; ENSMUSG00000032232

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
68178

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68178

UCSC genome browser

More...
UCSCi
uc009qpc.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093483 Genomic DNA No translation available.
AC107662 Genomic DNA No translation available.
BC139006 mRNA Translation: AAI39007.1
RefSeqiNP_001291291.1, NM_001304362.1
NP_080875.3, NM_026599.5
XP_006511458.1, XM_006511395.1
UniGeneiMm.99961

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072899; ENSMUSP00000072672; ENSMUSG00000032232
ENSMUST00000122065; ENSMUSP00000112479; ENSMUSG00000032232
GeneIDi68178
KEGGimmu:68178
UCSCiuc009qpc.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84952
MGIiMGI:1915428 Cgnl1

Phylogenomic databases

eggNOGiENOG410IGSJ Eukaryota
ENOG410YEC7 LUCA
GeneTreeiENSGT00940000154489
HOVERGENiHBG107670
KOiK21110
OMAiWTCFPKP
OrthoDBi110948at2759
TreeFamiTF332247

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cgnl1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032232 Expressed in 271 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR002928 Myosin_tail
PfamiView protein in Pfam
PF01576 Myosin_tail_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RSU6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RSU6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: January 16, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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