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Protein

Beta-1,3-N-acetylglucosaminyltransferase

Gene

Lfng

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.UniRule annotation

Cofactori

Mn2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128SubstrateUniRule annotation1
Binding sitei200SubstrateUniRule annotation1
Metal bindingi201UniRule annotation1
Active sitei289UniRule annotation1
Metal bindingi313UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-N-acetylglucosaminyltransferaseUniRule annotation (EC:2.4.1.222UniRule annotation)
Alternative name(s):
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:LfngImported
ORF Names:mCG_14497Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1095413 Lfng

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501508714726 – 378Beta-1,3-N-acetylglucosaminyltransferaseSequence analysisAdd BLAST353

Expressioni

Gene expression databases

BgeeiENSMUSG00000029570 Expressed in 251 organ(s), highest expression level in lumbar subsegment of spinal cord

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410II9W Eukaryota
ENOG410XS8Y LUCA
HOVERGENiHBG007986
KOiK05948
OMAiPHTQDVY
OrthoDBiEOG091G08XO

Family and domain databases

InterProiView protein in InterPro
IPR017374 Fringe
IPR003378 Fringe-like
PfamiView protein in Pfam
PF02434 Fringe, 1 hit
PIRSFiPIRSF038073 B-acetylgalactosaminyltfrase, 1 hit

Sequencei

Sequence statusi: Complete.

B2RRW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQRCGRRLL LALVGALLAC LLVLTADPPP TPMPAERGRR ALRSLAGSSG
60 70 80 90 100
GAPASGSRAA VDPGVLTREV HSLSEYFSLL TRARRDADPP PGVASRQGDG
110 120 130 140 150
HPRPPAEVLS PRDVFIAVKT TRKFHRARLD LLFETWISRH KEMTFIFTDG
160 170 180 190 200
EDEALAKLTG NVVLTNCSSA HSRQALSCKM AVEYDRFIES GKKWFCHVDD
210 220 230 240 250
DNYVNLRALL RLLASYPHTQ DVYIGKPSLD RPIQATERIS EHKVRPVHFW
260 270 280 290 300
FATGGAGFCI SRGLALKMGP WASGGHFMST AERIRLPDDC TIGYIVEALL
310 320 330 340 350
GVPLIRSGLF HSHLENLQQV PTTELHEQVT LSYGMFENKR NAVHIKGPFS
360 370
VEADPSRFRS VHCHLYPDTP WCPRSAIF
Length:378
Mass (Da):41,952
Last modified:July 1, 2008 - v1
Checksum:iFD0A02597BF9AFED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138600 mRNA Translation: AAI38601.1
BC138601 mRNA Translation: AAI38602.1
CH466529 Genomic DNA Translation: EDL19116.1
RefSeqiNP_032520.1, NM_008494.3
UniGeneiMm.12834

Genome annotation databases

GeneIDi16848
KEGGimmu:16848

Similar proteinsi

Entry informationi

Entry nameiB2RRW2_MOUSE
AccessioniPrimary (citable) accession number: B2RRW2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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