Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 106 (29 Sep 2021)
Sequence version 1 (01 Jul 2008)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

A kinase (PRKA) anchor protein (Gravin) 12

Gene

Akap12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-bindingPROSITE-ProRule annotation, KinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A kinase (PRKA) anchor protein (Gravin) 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akap12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932576, Akap12

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000038587

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B2RRE0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038587, Expressed in urinary bladder and 295 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2RRE0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini593 – 613AKAP_CAM_BDInterPro annotationAdd BLAST21
Domaini740 – 760AKAP_CAM_BDInterPro annotationAdd BLAST21
Domaini781 – 801AKAP_CAM_BDInterPro annotationAdd BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 124DisorderedSequence analysisAdd BLAST124
Regioni175 – 281DisorderedSequence analysisAdd BLAST107
Regioni296 – 353DisorderedSequence analysisAdd BLAST58
Regioni421 – 479DisorderedSequence analysisAdd BLAST59
Regioni492 – 825DisorderedSequence analysisAdd BLAST334
Regioni970 – 1001DisorderedSequence analysisAdd BLAST32
Regioni1055 – 1106DisorderedSequence analysisAdd BLAST52
Regioni1121 – 1211DisorderedSequence analysisAdd BLAST91
Regioni1232 – 1365DisorderedSequence analysisAdd BLAST134
Regioni1391 – 1492DisorderedSequence analysisAdd BLAST102
Regioni1568 – 1684DisorderedSequence analysisAdd BLAST117

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili837 – 857Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi593 – 613AKAP CaM-bindingPROSITE-ProRule annotationAdd BLAST21
Motifi740 – 760AKAP CaM-bindingPROSITE-ProRule annotationAdd BLAST21
Motifi781 – 801AKAP CaM-bindingPROSITE-ProRule annotationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Polar residuesSequence analysisAdd BLAST21
Compositional biasi85 – 108Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi175 – 193Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi225 – 243Polar residuesSequence analysisAdd BLAST19
Compositional biasi248 – 267Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi298 – 336Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi464 – 478Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi520 – 565Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi581 – 595Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi608 – 626Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi644 – 661Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi678 – 713Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi714 – 732Polar residuesSequence analysisAdd BLAST19
Compositional biasi748 – 789Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi976 – 998Polar residuesSequence analysisAdd BLAST23
Compositional biasi1061 – 1076Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1083 – 1097Polar residuesSequence analysisAdd BLAST15
Compositional biasi1121 – 1196Polar residuesSequence analysisAdd BLAST76
Compositional biasi1235 – 1251Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1269 – 1328Basic and acidic residuesSequence analysisAdd BLAST60
Compositional biasi1461 – 1492Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1568 – 1601Polar residuesSequence analysisAdd BLAST34
Compositional biasi1609 – 1625Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1649 – 1684Basic and acidic residuesSequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002691_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALWHAIF

Database of Orthologous Groups

More...
OrthoDBi
158752at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B2RRE0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028540, AKAP12
IPR001573, AKAP_WSK
IPR018459, RII-bd_1

The PANTHER Classification System

More...
PANTHERi
PTHR23209, PTHR23209, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10522, RII_binding_1, 1 hit
PF03832, WSK, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51893, AKAP_CAM_BD, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RRE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAGSSTEQR SPEQPAESDT PSELELSGHG PAAEASGAAG DPADADPATK
60 70 80 90 100
LPQKNGQLSA VNGVAEQEDV HVQEESQDGQ EEEVTVEDVG QRESEDVKEK
110 120 130 140 150
DRAKEMAASS TVVEDITKDE QEETPEIIEQ IPASESNVEE MAQAAESQAN
160 170 180 190 200
DVGFKKVFKF VGFKFTVKKD KNEKSDTVQL LTVKKDEGEG AEASVGAGDH
210 220 230 240 250
QEPGVETVGE SASKESELKQ STEKQEGTLK QAQSSTEIPL QAESGQGTEE
260 270 280 290 300
EAAKDGEENR EKEPTKPLES PTSPVSNETT SSFKKFFTHG WAGWRKKTSF
310 320 330 340 350
KKPKEDDLET SEKRKEQEAE KVDEEEGEKT EPAPAEEQEP AEGTDQARLS
360 370 380 390 400
ADYEKVELPL EDQVGDLEAL SEKCAPLATE VFDEKTEAHQ EVVAEVHVST
410 420 430 440 450
VEKMTKGQGG AEVEGDVVVE GSGESLPPEK LAETQEVPQE AEPVEELMKT
460 470 480 490 500
KEVCVSGGDH TQLTDLSPEE KMLPKHPEGI VSEVEMLSSQ ERIKVQGSPL
510 520 530 540 550
KKLFSSSGLK KLSGKKQKGK RGGGGGDEEP GEYQHIQTES PESADEQKGE
560 570 580 590 600
SSASSPEEPE EIACLEKGPS EAPQEAEAEE GATSDGEKKR EGITPWASFK
610 620 630 640 650
KMVTPKKRVR RPSESDKEEE LDKVKSATLS STESTASGMQ DEVRAVGEEQ
660 670 680 690 700
RSEEPKRRVD TSVSWEALIC VGSSKKRARK ASSSDDEGGP RTLGGDGHRA
710 720 730 740 750
EEASKDKEAD ALPASTQEQD QAHGSSSPEP AGSPSEGEGV STWESFKRLV
760 770 780 790 800
TPRKKSKSKL EERAEDSGAE QLASEIEPSR EESWVSIKKF IPGRRKKRAD
810 820 830 840 850
GKQEQAAVED SGPGEINEDD PDVPAVVPLS EYDAVEREKL EAQRAQENVE
860 870 880 890 900
LPQLKGAVYV SEELSKTLVH TVSVAVIDGT RAVTSAEERS PSWISASMTE
910 920 930 940 950
PLEHAEGVAT PPVGEVTEKD ITAEATPALA QTLPGGKDAH DDIVTSEVDF
960 970 980 990 1000
TSEAVTAAET TEALRAEELT EASGAEETTD MVSAVSQLSD SPDTTEEATP
1010 1020 1030 1040 1050
VQEVEGGMLD TEEQERQTQA VLQAVADKVK EDSQVPATQT LQRAGPKALE
1060 1070 1080 1090 1100
KVEEVEEDSE VLATEKEKDV VPEGPVQEAE TEHLAQGSET VQATPESLEV
1110 1120 1130 1140 1150
PEVTEDVDRA TTCQVIKHQQ LMEQAVAPES SETLTDSETN GSTPLADSDT
1160 1170 1180 1190 1200
PNGTQQDETV DSQDSNAIAA VKQSQVTEEE AAAAQTEGPS TPSSFPAQEE
1210 1220 1230 1240 1250
HREKPGRDVL EPTQALAAGA VPILAKAEVG QEGEAGQFDG EKVKDGQCVK
1260 1270 1280 1290 1300
ELEVPVHTGP NSQKTADLTR DSEVMEVARC QETESNEEQS ISPEKREMGT
1310 1320 1330 1340 1350
DVEKEETETK TEQASEEHEQ ETAAPEHEGT HPKPVLTADM PHSERGKALG
1360 1370 1380 1390 1400
SLEGSPSLPD QDKADCIEVQ VQSSDTPVTQ TTEAVKKVEE TVATSEMDES
1410 1420 1430 1440 1450
LECAGAQSLP AEKLSETGGY GTLQHGEDTV PQGPESQAES IPIIVTPAPE
1460 1470 1480 1490 1500
SILHSDLQRE VSASQKQRSD EDNKPDAGPD AAGKESAARE KILRAEPEIL
1510 1520 1530 1540 1550
ELESKSNKIV QSVIQTAVDQ FARTETAPET HASDLQNQVP VMQADSQGAQ
1560 1570 1580 1590 1600
QMLDKDESDL QVSPQDGTLS AVAQEGLAVS DSSEGMSKAS EMITTLAVES
1610 1620 1630 1640 1650
ASVKESVEKL PLQCKDEKEH AADGPQHQSL AKAEADASGN LTKESPDTNG
1660 1670 1680
PKLTEEGDAL KEEMNKAQTE EDDLQEPKGD LTES
Length:1,684
Mass (Da):180,695
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE569D55762FCB19E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC138364 mRNA Translation: AAI38365.1
BC138365 mRNA Translation: AAI38366.1

NCBI Reference Sequences

More...
RefSeqi
NP_112462.1, NM_031185.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:83397

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC138364 mRNA Translation: AAI38365.1
BC138365 mRNA Translation: AAI38366.1
RefSeqiNP_112462.1, NM_031185.3

3D structure databases

SMRiB2RRE0
ModBaseiSearch...

Proteomic databases

PeptideAtlasiB2RRE0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1199, 223 antibodies

The DNASU plasmid repository

More...
DNASUi
83397

Genome annotation databases

GeneIDi83397
KEGGimmu:83397

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9590
MGIiMGI:1932576, Akap12
VEuPathDBiHostDB:ENSMUSG00000038587

Phylogenomic databases

HOGENOMiCLU_002691_0_0_1
OMAiALWHAIF
OrthoDBi158752at2759
PhylomeDBiB2RRE0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
83397, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Akap12, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038587, Expressed in urinary bladder and 295 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR028540, AKAP12
IPR001573, AKAP_WSK
IPR018459, RII-bd_1
PANTHERiPTHR23209, PTHR23209, 1 hit
PfamiView protein in Pfam
PF10522, RII_binding_1, 1 hit
PF03832, WSK, 3 hits
PROSITEiView protein in PROSITE
PS51893, AKAP_CAM_BD, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RRE0_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RRE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 29, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again