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Protein

Peregrin

Gene

Brpf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 47C2H2-typePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri272 – 322PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri326 – 359C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri383 – 447PHD-type 2PROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
PeregrinCurated
Alternative name(s):
Bromodomain and PHD finger-containing protein 1Imported
Gene namesi
Name:Brpf1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1926033 Brpf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004398131 – 1212PeregrinAdd BLAST1212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineCombined sources1
Modified residuei147N6-acetyllysineCombined sources1
Modified residuei237PhosphoserineBy similarity1
Modified residuei459PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei579N6-acetyllysineCombined sources1
Modified residuei856PhosphothreonineCombined sources1
Modified residuei858PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1
Modified residuei924PhosphoserineCombined sources1
Modified residuei1074PhosphoserineBy similarity1
Modified residuei1185PhosphoserineBy similarity1

Post-translational modificationi

Acetylated by KAT6A.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiB2RRD7
PeptideAtlasiB2RRD7
PRIDEiB2RRD7

PTM databases

iPTMnetiB2RRD7
PhosphoSitePlusiB2RRD7

Expressioni

Gene expression databases

BgeeiENSMUSG00000001632 Expressed in 283 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiB2RRD7 baseline and differential

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). May interact with KAT7.By similarity

Structurei

3D structure databases

ProteinModelPortaliB2RRD7
SMRiB2RRD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini644 – 714BromoPROSITE-ProRule annotationAdd BLAST71
Domaini1083 – 1166PWWPPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 221Interaction with KAT6A and KAT6BBy similarityAdd BLAST163
Regioni500 – 819Interaction with MEAF6 and ING5By similarityAdd BLAST320
Regioni542 – 1077Required for RUNX1 and RUNX2 transcriptional activationBy similarityAdd BLAST536

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 47C2H2-typePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri272 – 322PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri326 – 359C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri383 – 447PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOVERGENiHBG004895
KOiK11348

Family and domain databases

CDDicd05839 BR140_related, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR013087 Znf_C2H2_type
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

B2RRD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDSP
60 70 80 90 100
PPPQQTPLRK HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE
110 120 130 140 150
VDLHGRVHRI SIFDNLDVVS EDEEAPEEAP ENGSNKENTE TPAATPKSGK
160 170 180 190 200
HKNKEKRKDS NHHHHSAPAS AAPKLPEVVY RELEQDTPDA PPRPTSYYRY
210 220 230 240 250
IEKSAEELDE EVEYDMDEED YIWLDIMNER RKTEGVSPIP QEIFEYLMDR
260 270 280 290 300
LEKESYFESH NKGDPNALVD EDAVCCICND GECQNSNVIL FCDMCNLAVH
310 320 330 340 350
QECYGVPYIP EGQWLCRRCL QSPSRAVDCA LCPNKGGAFK QTDDGRWAHV
360 370 380 390 400
VCALWIPEVC FANTVFLEPI DSIEHIPPAR WKLTCYICKQ RGSGACIQCH
410 420 430 440 450
KANCYTAFHV TCAQQAGLYM KMEPVRETGA NGTSFSVRKT AYCDIHTPPG
460 470 480 490 500
SARRLPALSH SEGEEEEDEE EDEGKSWSSE KVKKAKAKSR IKMKKARKIL
510 520 530 540 550
AEKRAAAPVV SVPCIPPHRL SKITNRLTIQ RKSQFMQRLH SYWTLKRQSR
560 570 580 590 600
NGVPLLRRLQ THLQSQRNCE QVGRDSDDKN WALKEQLKSW QRLRHDLERA
610 620 630 640 650
RLLVELIRKR EKLKRETIKI QQIAMEMQLT PFLILLRKTL EQLQEKDTGN
660 670 680 690 700
IFSEPVPLSE VPDYLDHIKK PMDFFTMKQN LEAYRYLNFD DFEEDFNLIV
710 720 730 740 750
SNCLKYNAKD TIFYRAAVRL REQGGAVLRQ ARRQAEKMGI DFETGMHIPH
760 770 780 790 800
NLAGDEVSHH TEDVEEERLV LLENQKHLPV EEQLKLLLER LDEVNASKQS
810 820 830 840 850
VGRSRRAKMI KKEMTALRRK LAHQRETGRD GPERHGPSGR GNLTPHPAAC
860 870 880 890 900
DKDGQTDSAA EESSSQETSK GLGPNMSSTP AHEVGRRTSV LFSKKNPKTA
910 920 930 940 950
GPPKRPGRPP KNRESQMTPS HGGSPVGPPQ LPIMGSLRQR KRGRSPRPSS
960 970 980 990 1000
SSDSDSDKST EDPPMDLPAN GFSSGNQPVK KSFLVYRNDC NLPRSSSDSE
1010 1020 1030 1040 1050
SSSSSSSSAA SDRTSTTPSK QGRGKPSFSR GTFPEDSSED TSGTENEAYS
1060 1070 1080 1090 1100
VGTGRGVGHS MVRKSLGRGA GWLSEDEDSP LDALDLVWAK CRGYPSYPAL
1110 1120 1130 1140 1150
IIDPKMPREG MFHHGVPIPV PPLEVLKLGE QMTQEAREHL YLVLFFDNKR
1160 1170 1180 1190 1200
TWQWLPRTKL VPLGVNQDLD KEKMLEGRKS NIRKSVQIAY HRALQHRSKV
1210
QGEQSSETSD SD
Length:1,212
Mass (Da):137,310
Last modified:July 1, 2008 - v1
Checksum:i2FC14ECF8FF5DECE
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U109Q3U109_MOUSE
Peregrin
Brpf1
1,247Annotation score:
Q80XK2Q80XK2_MOUSE
Bromodomain and PHD finger containi...
Brpf1
1,246Annotation score:
E9PXP1E9PXP1_MOUSE
Peregrin
Brpf1
1,219Annotation score:
A0A0N4SUT9A0A0N4SUT9_MOUSE
Peregrin
Brpf1
1,252Annotation score:
A0A0N4SUS4A0A0N4SUS4_MOUSE
Peregrin
Brpf1
1,118Annotation score:
A0A0N4SVG7A0A0N4SVG7_MOUSE
Peregrin
Brpf1
1,218Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155287 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99448.1
BC138361 mRNA Translation: AAI38362.1
CCDSiCCDS71810.1
RefSeqiNP_001269056.1, NM_001282127.1
XP_006506851.1, XM_006506788.3
UniGeneiMm.356059
Mm.449928
Mm.474132

Genome annotation databases

EnsembliENSMUST00000113122; ENSMUSP00000108747; ENSMUSG00000001632
GeneIDi78783
KEGGimmu:78783
UCSCiuc009dfb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155287 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99448.1
BC138361 mRNA Translation: AAI38362.1
CCDSiCCDS71810.1
RefSeqiNP_001269056.1, NM_001282127.1
XP_006506851.1, XM_006506788.3
UniGeneiMm.356059
Mm.449928
Mm.474132

3D structure databases

ProteinModelPortaliB2RRD7
SMRiB2RRD7
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB2RRD7
PhosphoSitePlusiB2RRD7

Proteomic databases

MaxQBiB2RRD7
PeptideAtlasiB2RRD7
PRIDEiB2RRD7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113122; ENSMUSP00000108747; ENSMUSG00000001632
GeneIDi78783
KEGGimmu:78783
UCSCiuc009dfb.1 mouse

Organism-specific databases

CTDi7862
MGIiMGI:1926033 Brpf1

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA
GeneTreeiENSGT00740000114866
HOVERGENiHBG004895
KOiK11348

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRSiBrpf1 mouse
PROiPR:B2RRD7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001632 Expressed in 283 organ(s), highest expression level in humerus cartilage element
ExpressionAtlasiB2RRD7 baseline and differential

Family and domain databases

CDDicd05839 BR140_related, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR013087 Znf_C2H2_type
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRPF1_MOUSE
AccessioniPrimary (citable) accession number: B2RRD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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