UniProtKB - B2RR24 (B2RR24_MOUSE)
Protein
Submitted name:
Zinc finger protein 236
Gene
Zfp236
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
GO - Biological processi
- cellular response to glucose stimulus Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger protein 236Imported |
Gene namesi | Name:Zfp236Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1926950, Zfp236 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041258, Expressed in blood and 255 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | B2RR24, 1 interactor |
STRINGi | 10090.ENSMUSP00000130004 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 39 – 67 | C2H2-typeInterPro annotationAdd BLAST | 29 | |
Domaini | 68 – 95 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 95 – 122 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 123 – 150 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 155 – 182 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 199 – 226 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 227 – 254 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 255 – 283 | C2H2-typeInterPro annotationAdd BLAST | 29 | |
Domaini | 436 – 463 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 464 – 491 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 492 – 519 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 520 – 550 | C2H2-typeInterPro annotationAdd BLAST | 31 | |
Domaini | 611 – 638 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 639 – 666 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 667 – 694 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 695 – 722 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 922 – 949 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 950 – 977 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 978 – 1005 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1006 – 1033 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1122 – 1149 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1150 – 1177 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1178 – 1205 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1206 – 1233 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1612 – 1640 | C2H2-typeInterPro annotationAdd BLAST | 29 | |
Domaini | 1641 – 1668 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1677 – 1704 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1705 – 1732 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 1733 – 1757 | C2H2-typeInterPro annotationAdd BLAST | 25 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 361 – 420 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 805 – 838 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1041 – 1065 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1222 – 1249 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1417 – 1442 | DisorderedSequence analysisAdd BLAST | 26 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1097 – 1117 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 15 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 368 – 387 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 393 – 419 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 822 – 838 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1222 – 1241 | PolyampholyteSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156787 |
HOGENOMi | CLU_002361_0_0_1 |
OMAi | HSGSQLM |
TreeFami | TF350781 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 18 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 29 hits |
SUPFAMi | SSF57667, SSF57667, 15 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 29 hits PS50157, ZINC_FINGER_C2H2_2, 29 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
B2RR24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRGRPPKPR DGAARGDSDG VLALNDEDID DDCPIPNFHK CEICLLSFPK
60 70 80 90 100
ESQFQRHMRE HEQNDKPHRC DQCPQTFNVE FNLTLHKCTH NAEDPVCPVC
110 120 130 140 150
NKKFSRVASL KAHIMLHEKE ENLICSECGD EFTLHSQLAI HMEEHRQELA
160 170 180 190 200
NTRAHTCKAC KKEFETSPEL KEHMKTHCKV RASGTRSYNR NIDRSSFPYS
210 220 230 240 250
CPHCGKTFQK PSQLTRHIRI HTGERPFKCS ECGKAFNQKG ALQTHMIKHT
260 270 280 290 300
GEKPHACAFC PAAFSQKGNL QSHVQRVHSE ATIFQTLPLQ QVEAQVSSVS
310 320 330 340 350
SEQSSQAVSD VIQQLLELSE PGPVEAQQSP QSGRQLSVTV GINQDILQQA
360 370 380 390 400
LENSGLSSLP VAAPPSDCSH AQTATVSTQS PHASSVSAEQ ADPMDAEQEK
410 420 430 440 450
GQESPEKTDK KEKKLLKKKS PFLPGSIREE NGVRWHVCPY CTKEFRKPSD
460 470 480 490 500
LVRHIRIHTH EKPFKCPQCF RAFAVKSTLT AHIKTHTGIK AFKCQYCMKS
510 520 530 540 550
FSTSGSLKVH IRLHTGVRPF ACPHCDKKFR TSGHRKTHVA SHFKHTELRK
560 570 580 590 600
LRQQRKPVKG RVGKSSVPVP DIPLQEPILI TDLGLIQPIP KNQFFQNYFN
610 620 630 640 650
NSFGNEADRP YKCFYCHRAY KKSCHLKQHI RSHTGEKPFK CSQCGRGFVS
660 670 680 690 700
AGVLKAHVRT HTGLKSFKCL ICNGAFTTGG SLRRHMGIHN DLRPYMCPYC
710 720 730 740 750
QKTFKTSLNC KKHMKTHRYE LAQQLQQHQE ASSMDDDSTV DQQSMHVAAP
760 770 780 790 800
MPVEIESAEL QQTPETVAAD PESILELGPQ HVVGTEDAAL GQQLADQPLE
810 820 830 840 850
ADEDGFTASQ APLPGHMDQF EEQGTPQPSF ESAGLPQGFT VTDTYSQQTS
860 870 880 890 900
FPPVQQLQDS STLESQALST SFHQQNLLQV PNSDAINVAT RLLPESSQED
910 920 930 940 950
LDLQTQGPQF LEDSEDQSRR SYRCDYCNKG FKKSSHLKQH VRSHTGEKPY
960 970 980 990 1000
KCKLCGRAFV SSGVLKSHEK THTGVKAFSC SICNASFTTN GSLTRHMATH
1010 1020 1030 1040 1050
MSMKPYKCPF CEEGFRTAVH CRKHMKRHQA VSSAAAAAAE TEGGDTCVEE
1060 1070 1080 1090 1100
DEENSDRSAS RKPRPEVITF TEEETAQLAK IQPQESATVS EKVLVQSAAE
1110 1120 1130 1140 1150
KDRISEMKDK QAELEAEPKH ANCCTYCPKS FKKPSDLVRH VRIHTGEKPY
1160 1170 1180 1190 1200
KCDECGKSFT VKSTLDCHVK THTGQKLFSC HVCSNAFSTK GSLKVHMRLH
1210 1220 1230 1240 1250
TGAKPFKCPH CELRFRTSGR RKTHMQFHYK SDPKKARKPV TRSSSESLQS
1260 1270 1280 1290 1300
VNLLNSSSTD PNVFIMNNSV LTGQFDQNVL QPGLVGQAIL PASVSAGGDL
1310 1320 1330 1340 1350
TVSLTDGSLA TLEGIQLQLA ANLVGPNVQI SGIDASSINN ITLQIDPSIL
1360 1370 1380 1390 1400
QQTLQQGSLL AQPITGESST ASQNSSLQTS DSTVPASVVI QPLSGLSLQP
1410 1420 1430 1440 1450
TVTSANLTIG PLSEQDSVLT TSSSGSQDLS QVMTSQGLVS TSTGPHEITL
1460 1470 1480 1490 1500
TINNSSLSQV LAQAAGPTAS SSSGSPQEIT LTISELNPSS GSLPSTAPMS
1510 1520 1530 1540 1550
PSAISAQNLV MSSSGVGADA SVTLTLADTQ GVLSGGLDTV TLNITSQGQQ
1560 1570 1580 1590 1600
FPALLTDPSL SGQGGAGSPQ VILVSHTPQS SSAAGEEIAY QVTDVPAQLT
1610 1620 1630 1640 1650
PHSQPEKEGL SHQCLDCDRA FSSAAVLMHH SKEVHGKERI HGCRVCRKAF
1660 1670 1680 1690 1700
KRATHLKEHM LTHQAGPSLS SQKPRVFKCD SCEKAFAKPS QLERHSRIHT
1710 1720 1730 1740 1750
GERPFHCTLC DKAFNQKSAL QVHLKKHTGE RPYRCDYCVM GFTQKSNMKL
1760 1770 1780 1790
HMKRAHSFVG TLQAATVVQE QDGDELRTLH LEEVVPEAAG EWQTLTNVF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R299 | S4R299_MOUSE | Zinc finger protein 236 | Zfp236 | 1,847 | Annotation score: | ||
S4R1D8 | S4R1D8_MOUSE | Zinc finger protein 236 | Zfp236 | 485 | Annotation score: | ||
S4R1R9 | S4R1R9_MOUSE | Zinc finger protein 236 | Zfp236 | 429 | Annotation score: | ||
S4R1Z3 | S4R1Z3_MOUSE | Zinc finger protein 236 | Zfp236 | 43 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC119259 Genomic DNA No translation available. AC158975 Genomic DNA No translation available. BC138187 mRNA Translation: AAI38188.1 |
RefSeqi | NP_808500.2, NM_177832.3 |
Genome annotation databases
Ensembli | ENSMUST00000171071; ENSMUSP00000130004; ENSMUSG00000041258 |
GeneIDi | 329002 |
UCSCi | uc008fub.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC119259 Genomic DNA No translation available. AC158975 Genomic DNA No translation available. BC138187 mRNA Translation: AAI38188.1 |
RefSeqi | NP_808500.2, NM_177832.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B2RR24, 1 interactor |
STRINGi | 10090.ENSMUSP00000130004 |
Protocols and materials databases
Antibodypediai | 1786, 38 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000171071; ENSMUSP00000130004; ENSMUSG00000041258 |
GeneIDi | 329002 |
UCSCi | uc008fub.2, mouse |
Organism-specific databases
CTDi | 329002 |
MGIi | MGI:1926950, Zfp236 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156787 |
HOGENOMi | CLU_002361_0_0_1 |
OMAi | HSGSQLM |
TreeFami | TF350781 |
Miscellaneous databases
BioGRID-ORCSi | 329002, 4 hits in 12 CRISPR screens |
ChiTaRSi | Zfp236, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041258, Expressed in blood and 255 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 18 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 29 hits |
SUPFAMi | SSF57667, SSF57667, 15 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 29 hits PS50157, ZINC_FINGER_C2H2_2, 29 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RR24_MOUSE | |
Accessioni | B2RR24Primary (citable) accession number: B2RR24 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |