UniProtKB - B2RQQ8 (B2RQQ8_MOUSE)
Protein
Submitted name:
Collagen, type IV, alpha 2
Gene
Col4a2
Organism
Mus musculus (Mouse)
Status
Functioni
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.ARBA annotation
GO - Molecular functioni
- extracellular matrix structural constituent Source: InterPro
GO - Biological processi
- aging Source: Ensembl
- endodermal cell differentiation Source: Ensembl
- negative regulation of angiogenesis Source: Ensembl
- response to activity Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: Collagen, type IV, alpha 2Imported |
Gene namesi | Name:Col4a2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88455, Col4a2 |
Subcellular locationi
Extracellular region or secreted
- basement membrane ARBA annotation
Other locations
- Membrane ARBA annotation
Extracellular region or secreted
- basement membrane Source: UniProtKB-SubCell
Other locations
- collagen trimer Source: UniProtKB-KW
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Basement membraneARBA annotation, Extracellular matrix, SecretedPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
PeptideAtlasi | B2RQQ8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031503, Expressed in epithelium of lens and 317 other tissues |
ExpressionAtlasi | B2RQQ8, baseline and differential |
Family & Domainsi
Keywords - Domaini
CollagenImportedARBA annotationPhylogenomic databases
HOGENOMi | CLU_002023_1_0_1 |
OMAi | WYGENIK |
OrthoDBi | 63831at2759 |
Family and domain databases
Gene3Di | 2.170.240.10, 1 hit |
InterProi | View protein in InterPro IPR008160, Collagen IPR001442, Collagen_IV_NC IPR036954, Collagen_IV_NC_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF01413, C4, 2 hits PF01391, Collagen, 16 hits |
SMARTi | View protein in SMART SM00111, C4, 2 hits |
SUPFAMi | SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS51403, NC1_IV, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RQQ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRVRFKASG PPLRGWLLLA TVTVGLLAQS VLGGVKKLDV PCGGRDCSGG
60 70 80 90 100
CQCYPEKGAR GQPGAVGPQG YNGPPGLQGF PGLQGRKGDK GERGVPGPTG
110 120 130 140 150
PKGDVGARGV SGFPGADGIP GHPGQGGPRG RPGYDGCNGT RGDAGPQGPS
160 170 180 190 200
GSGGFPGLPG PQGPKGQKGE PYALSKEDRD KYRGEPGEPG LVGYQGPPGR
210 220 230 240 250
PGPIGQMGPM GAPGRPGPPG PPGPKGQPGN RGLGFYGQKG EKGDIGQPGP
260 270 280 290 300
NGIPSDITLV GPTTSTIHPD LYKGEKGDEG EQGIPGVISK GEEGIMGFPG
310 320 330 340 350
IRGFPGLDGE KGVVGQKGSR GLDGFQGPSG PRGPKGERGE QGPPGPSVYS
360 370 380 390 400
PHPSLAKGAR GDPGFQGAHG EPGSRGEPGE PGTAGPPGPS VGDEDSMRGL
410 420 430 440 450
PGEMGPKGFS GEPGSPARYL GPPGADGRPG PQGVPGPAGP PGPDGFLFGL
460 470 480 490 500
KGSEGRVGYP GPSGFPGTRG QKGWKGEAGD CQCGQVIGGL PGLPGPKGFP
510 520 530 540 550
GVNGELGKKG DQGDPGLHGI PGFPGFKGAP GVAGAPGPKG IKGDSRTITT
560 570 580 590 600
KGERGQPGIP GVHGMKGDDG VPGRDGLDGF PGLPGPPGDG IKGPPGDAGL
610 620 630 640 650
PGVPGTKGFP GDIGPPGQGL PGPKGERGFP GDAGLPGPPG FPGPPGPPGT
660 670 680 690 700
PGQRDCDTGV KRPIGGGQQV VVQPGCIEGP TGSPGQPGPP GPTGAKGVRG
710 720 730 740 750
MPGFPGASGE QGLKGFPGDP GREGFPGPPG FMGPRGSKGT TGLPGPDGPP
760 770 780 790 800
GPIGLPGPAG PPGDRGIPGE VLGAQPGTRG DAGLPGQPGL KGLPGETGAP
810 820 830 840 850
GFRGSQGMPG MPGLKGQPGF PGPSGQPGQS GPPGQHGFPG TPGREGPLGQ
860 870 880 890 900
PGSPGLGGLP GDRGEPGDPG VPGPVGMKGL SGDRGDAGMS GERGHPGSPG
910 920 930 940 950
FKGMAGMPGI PGQKGDRGSP GMDGFQGMLG LKGRQGFPGT KGEAGFFGVP
960 970 980 990 1000
GLKGLPGEPG VKGNRGDRGP PGPPPLILPG MKDIKGEKGD EGPMGLKGYL
1010 1020 1030 1040 1050
GLKGIQGMPG VPGVSGFPGL PGRPGFIKGV KGDIGVPGTP GLPGFPGVSG
1060 1070 1080 1090 1100
PPGITGFPGF TGSRGEKGTP GVAGVFGETG PTGDFGDIGD TVDLPGSPGL
1110 1120 1130 1140 1150
KGERGITGIP GLKGFFGEKG AAGDIGFPGI TGMAGAQGSP GLKGQTGFPG
1160 1170 1180 1190 1200
LTGLQGPQGE PGRIGIPGDK GDFGWPGVPG LPGFPGIRGI SGLHGLPGTK
1210 1220 1230 1240 1250
GFPGSPGVDA HGDPGFPGPT GDRGDRGEAN TLPGPVGVPG QKGERGTPGE
1260 1270 1280 1290 1300
RGPAGSPGLQ GFPGISPPSN ISGSPGDVGA PGIFGLQGYQ GPPGPPGPNA
1310 1320 1330 1340 1350
LPGIKGDEGS SGAAGFPGQK GWVGDPGPQG QPGVLGLPGE KGPKGEQGFM
1360 1370 1380 1390 1400
GNTGPSGAVG DRGPKGPKGD QGFPGAPGSM GSPGIPGIPQ KIAVQPGTLG
1410 1420 1430 1440 1450
PQGRRGLPGA LGEIGPQGPP GDPGFRGAPG KAGPQGRGGV SAVPGFRGDQ
1460 1470 1480 1490 1500
GPMGHQGPVG QEGEPGRPGS PGLPGMPGRS VSIGYLLVKH SQTDQEPMCP
1510 1520 1530 1540 1550
VGMNKLWSGY SLLYFEGQEK AHNQDLGLAG SCLARFSTMP FLYCNPGDVC
1560 1570 1580 1590 1600
YYASRNDKSY WLSTTAPLPM MPVAEEEIKP YISRCSVCEA PAVAIAVHSQ
1610 1620 1630 1640 1650
DTSIPHCPAG WRSLWIGYSF LMHTAAGDEG GGQSLVSPGS CLEDFRATPF
1660 1670 1680 1690 1700
IECNGGRGTC HYFANKYSFW LTTIPEQNFQ STPSADTLKA GLIRTHISRC
QVCMKNL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138040 mRNA Translation: AAI38041.1 |
RefSeqi | NP_034062.3, NM_009932.4 |
Genome annotation databases
GeneIDi | 12827 |
KEGGi | mmu:12827 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138040 mRNA Translation: AAI38041.1 |
RefSeqi | NP_034062.3, NM_009932.4 |
3D structure databases
SMRi | B2RQQ8 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | B2RQQ8 |
Protocols and materials databases
Antibodypediai | 4381, 229 antibodies |
Genome annotation databases
GeneIDi | 12827 |
KEGGi | mmu:12827 |
Organism-specific databases
CTDi | 1284 |
MGIi | MGI:88455, Col4a2 |
Phylogenomic databases
HOGENOMi | CLU_002023_1_0_1 |
OMAi | WYGENIK |
OrthoDBi | 63831at2759 |
Miscellaneous databases
BioGRID-ORCSi | 12827, 1 hit in 17 CRISPR screens |
ChiTaRSi | Col4a2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031503, Expressed in epithelium of lens and 317 other tissues |
ExpressionAtlasi | B2RQQ8, baseline and differential |
Family and domain databases
Gene3Di | 2.170.240.10, 1 hit |
InterProi | View protein in InterPro IPR008160, Collagen IPR001442, Collagen_IV_NC IPR036954, Collagen_IV_NC_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF01413, C4, 2 hits PF01391, Collagen, 16 hits |
SMARTi | View protein in SMART SM00111, C4, 2 hits |
SUPFAMi | SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS51403, NC1_IV, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RQQ8_MOUSE | |
Accessioni | B2RQQ8Primary (citable) accession number: B2RQQ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |