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Protein

Storkhead-box protein 1

Gene

Stox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (By similarity). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (PubMed:25677106). Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (By similarity). Induces phosphorylation of MAPT/tau (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Storkhead-box protein 1Imported
Gene namesi
Name:Stox1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2684909 Stox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004332981 – 990Storkhead-box protein 1CuratedAdd BLAST990

Proteomic databases

PaxDbiB2RQL2
PRIDEiB2RQL2

PTM databases

iPTMnetiB2RQL2
PhosphoSitePlusiB2RQL2

Expressioni

Tissue specificityi

Detected in sensory epithelial cells of the inner ear but not in adjacent surrounding tissue (at protein level).1 Publication

Developmental stagei

Highly expressed at E14 with lower levels at E18 and P3.1 Publication

Gene expression databases

BgeeiENSMUSG00000036923 Expressed in 75 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiB2RQL2 baseline and differential
GenevisibleiB2RQL2 MM

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3897 Eukaryota
ENOG410ZJ97 LUCA
GeneTreeiENSGT00520000055589
HOGENOMiHOG000054189
HOVERGENiHBG080004
InParanoidiB2RQL2
OMAiYPGIAIP
OrthoDBiEOG091G0CHI
TreeFamiTF337253

Family and domain databases

InterProiView protein in InterPro
IPR019391 Storkhead-box_winged-helix
PfamiView protein in Pfam
PF10264 Stork_head, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B2RQL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPVQLAPG SLALVLSPRE AGQAAGEPGG RALFRAFRRA NARCFWNARL
60 70 80 90 100
ARAASRLAFL GWLRRGVLLV RAPQPCVQVL RDAWRRRALR PPRGFRITAV
110 120 130 140 150
GDVFPVQMSP IAQCRFVPLA EVLCCAIADM NAAQVMVTQQ SLLEHLIKHY
160 170 180 190 200
PGIAVPSPDI LYSTLGALIQ ERKIYHTGEG YFIVTPSTYF ITNTPMQGNK
210 220 230 240 250
SALLSNEGCS GPTSGTYLVS VDCCAEPTQE NEALFSHCPS CQCYPDTSMC
260 270 280 290 300
DSKDLLTAAE VTRKSQEGLE ETTALTENQV VSASEDTHIC VNPKPLPYTK
310 320 330 340 350
DKGKRFGFGF LWRSLSRKEK PKAEYHSFSA QFPPEEWPVR DEDSSTKIPR
360 370 380 390 400
DVEHALIKRI NPVLTVDNLT KHTALMQKYE EQKKYNSQGT SMDILTTRHK
410 420 430 440 450
DSSKEVIGKR QGQFAKSRRR GSSHKGRHKA RSQGSELEPG NPGQEKEKQP
460 470 480 490 500
KVPAAQPAPR TKSPSEQVHH LQGRNPAVLG SHLIYKKQIN NPFQGMHLRK
510 520 530 540 550
HSVSKGHAVQ KTHGLKPTCV GPEEKPFWSA GSSDPSGVFD GEAQPPYPEQ
560 570 580 590 600
CRDKLEAGST QVAKAPVHPV SDDFRGGPGN YPPRRVLPGP SRCCSFRESM
610 620 630 640 650
LRPGVYHEEN KDLPEVLRKS WSTCDMFLGT KEKKQALPAQ RCSLDPDSSS
660 670 680 690 700
VHAEDKTVDK ILHQFQNLGL LDCPAGANRL RTHERQDGNS EELSRKALQI
710 720 730 740 750
PEAEIVNMEN EGLSDSEQDQ VALSHSDPGA GDDGGCSSLC LEDDDFSETD
760 770 780 790 800
DFCPSLPGHT QHSFAGGGTW NHLGTPAMTG KSLTDCNSKA HRLELLAIER
810 820 830 840 850
NPWYKATGLF SNAGESPNPD LSDNPGQNSR IPWGFNYEGE PTVAHVQTPA
860 870 880 890 900
AAAGRSLLAC STVRTTSFPV EILQESPGDR GKSPIVWRQS LPSQEMKEHF
910 920 930 940 950
TDKLQLVKTS HGPVSAQEPQ GEHLEGTENY SMTGDSGIDS PRTQSLVSTN
960 970 980 990
SAILDGFKRR QHFLPNREGV QKSQNLASNS LFQLTPAINV
Length:990
Mass (Da):108,902
Last modified:July 1, 2008 - v1
Checksum:iE57F3D1B188F7A23
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QZ35F6QZ35_MOUSE
Storkhead-box protein 1
Stox1
136Annotation score:
F6YZ72F6YZ72_MOUSE
Storkhead-box protein 1
Stox1
39Annotation score:

Sequence cautioni

The sequence BAE21776 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122539 Genomic DNA No translation available.
BC137978 mRNA Translation: AAI37979.1
AK133671 mRNA Translation: BAE21776.1 Different initiation.
CCDSiCCDS48580.1
RefSeqiNP_001028432.1, NM_001033260.1
UniGeneiMm.39821

Genome annotation databases

EnsembliENSMUST00000133371; ENSMUSP00000114652; ENSMUSG00000036923
GeneIDi216021
KEGGimmu:216021
UCSCiuc011xfe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122539 Genomic DNA No translation available.
BC137978 mRNA Translation: AAI37979.1
AK133671 mRNA Translation: BAE21776.1 Different initiation.
CCDSiCCDS48580.1
RefSeqiNP_001028432.1, NM_001033260.1
UniGeneiMm.39821

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiB2RQL2
PhosphoSitePlusiB2RQL2

Proteomic databases

PaxDbiB2RQL2
PRIDEiB2RQL2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000133371; ENSMUSP00000114652; ENSMUSG00000036923
GeneIDi216021
KEGGimmu:216021
UCSCiuc011xfe.1 mouse

Organism-specific databases

CTDi219736
MGIiMGI:2684909 Stox1

Phylogenomic databases

eggNOGiKOG3897 Eukaryota
ENOG410ZJ97 LUCA
GeneTreeiENSGT00520000055589
HOGENOMiHOG000054189
HOVERGENiHBG080004
InParanoidiB2RQL2
OMAiYPGIAIP
OrthoDBiEOG091G0CHI
TreeFamiTF337253

Miscellaneous databases

PROiPR:B2RQL2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036923 Expressed in 75 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiB2RQL2 baseline and differential
GenevisibleiB2RQL2 MM

Family and domain databases

InterProiView protein in InterPro
IPR019391 Storkhead-box_winged-helix
PfamiView protein in Pfam
PF10264 Stork_head, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTOX1_MOUSE
AccessioniPrimary (citable) accession number: B2RQL2
Secondary accession number(s): Q3UZS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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