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Entry version 82 (02 Jun 2021)
Sequence version 1 (01 Jul 2008)
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Protein

Storkhead-box protein 1

Gene

Stox1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (By similarity).

Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (PubMed:25677106).

Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (By similarity).

Induces phosphorylation of MAPT/tau (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processCell cycle, Cell division, Mitosis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Storkhead-box protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Stox1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2684909, Stox1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004332981 – 990Storkhead-box protein 1CuratedAdd BLAST990

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B2RQL2

PRoteomics IDEntifications database

More...
PRIDEi
B2RQL2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
257460

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B2RQL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B2RQL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in sensory epithelial cells of the inner ear but not in adjacent surrounding tissue (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed at 14 dpc with lower levels at 18 dpc and P3.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036923, Expressed in spermatocyte and 122 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B2RQL2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000114652

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
B2RQL2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni396 – 471DisorderedSequence analysisAdd BLAST76
Regioni562 – 586DisorderedSequence analysisAdd BLAST25
Regioni712 – 736DisorderedSequence analysisAdd BLAST25
Regioni809 – 832DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi413 – 428Basic residuesSequence analysisAdd BLAST16
Compositional biasi811 – 831Polar residuesSequence analysisAdd BLAST21

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3897, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055589

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_306723_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B2RQL2

Identification of Orthologs from Complete Genome Data

More...
OMAi
TNPGESQ

Database of Orthologous Groups

More...
OrthoDBi
494782at2759

TreeFam database of animal gene trees

More...
TreeFami
TF337253

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019391, Storkhead-box_winged-helix
IPR040126, STOX1/2

The PANTHER Classification System

More...
PANTHERi
PTHR22437, PTHR22437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10264, Stork_head, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B2RQL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPVQLAPG SLALVLSPRE AGQAAGEPGG RALFRAFRRA NARCFWNARL
60 70 80 90 100
ARAASRLAFL GWLRRGVLLV RAPQPCVQVL RDAWRRRALR PPRGFRITAV
110 120 130 140 150
GDVFPVQMSP IAQCRFVPLA EVLCCAIADM NAAQVMVTQQ SLLEHLIKHY
160 170 180 190 200
PGIAVPSPDI LYSTLGALIQ ERKIYHTGEG YFIVTPSTYF ITNTPMQGNK
210 220 230 240 250
SALLSNEGCS GPTSGTYLVS VDCCAEPTQE NEALFSHCPS CQCYPDTSMC
260 270 280 290 300
DSKDLLTAAE VTRKSQEGLE ETTALTENQV VSASEDTHIC VNPKPLPYTK
310 320 330 340 350
DKGKRFGFGF LWRSLSRKEK PKAEYHSFSA QFPPEEWPVR DEDSSTKIPR
360 370 380 390 400
DVEHALIKRI NPVLTVDNLT KHTALMQKYE EQKKYNSQGT SMDILTTRHK
410 420 430 440 450
DSSKEVIGKR QGQFAKSRRR GSSHKGRHKA RSQGSELEPG NPGQEKEKQP
460 470 480 490 500
KVPAAQPAPR TKSPSEQVHH LQGRNPAVLG SHLIYKKQIN NPFQGMHLRK
510 520 530 540 550
HSVSKGHAVQ KTHGLKPTCV GPEEKPFWSA GSSDPSGVFD GEAQPPYPEQ
560 570 580 590 600
CRDKLEAGST QVAKAPVHPV SDDFRGGPGN YPPRRVLPGP SRCCSFRESM
610 620 630 640 650
LRPGVYHEEN KDLPEVLRKS WSTCDMFLGT KEKKQALPAQ RCSLDPDSSS
660 670 680 690 700
VHAEDKTVDK ILHQFQNLGL LDCPAGANRL RTHERQDGNS EELSRKALQI
710 720 730 740 750
PEAEIVNMEN EGLSDSEQDQ VALSHSDPGA GDDGGCSSLC LEDDDFSETD
760 770 780 790 800
DFCPSLPGHT QHSFAGGGTW NHLGTPAMTG KSLTDCNSKA HRLELLAIER
810 820 830 840 850
NPWYKATGLF SNAGESPNPD LSDNPGQNSR IPWGFNYEGE PTVAHVQTPA
860 870 880 890 900
AAAGRSLLAC STVRTTSFPV EILQESPGDR GKSPIVWRQS LPSQEMKEHF
910 920 930 940 950
TDKLQLVKTS HGPVSAQEPQ GEHLEGTENY SMTGDSGIDS PRTQSLVSTN
960 970 980 990
SAILDGFKRR QHFLPNREGV QKSQNLASNS LFQLTPAINV
Length:990
Mass (Da):108,902
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE57F3D1B188F7A23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6QZ35F6QZ35_MOUSE
Storkhead-box protein 1
Stox1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YZ72F6YZ72_MOUSE
Storkhead-box protein 1
Stox1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE21776 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122539 Genomic DNA No translation available.
BC137978 mRNA Translation: AAI37979.1
AK133671 mRNA Translation: BAE21776.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48580.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028432.1, NM_001033260.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000133371; ENSMUSP00000114652; ENSMUSG00000036923

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
216021

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:216021

UCSC genome browser

More...
UCSCi
uc011xfe.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122539 Genomic DNA No translation available.
BC137978 mRNA Translation: AAI37979.1
AK133671 mRNA Translation: BAE21776.1 Different initiation.
CCDSiCCDS48580.1
RefSeqiNP_001028432.1, NM_001033260.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114652

PTM databases

iPTMnetiB2RQL2
PhosphoSitePlusiB2RQL2

Proteomic databases

PaxDbiB2RQL2
PRIDEiB2RQL2
ProteomicsDBi257460

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51097, 70 antibodies

Genome annotation databases

EnsembliENSMUST00000133371; ENSMUSP00000114652; ENSMUSG00000036923
GeneIDi216021
KEGGimmu:216021
UCSCiuc011xfe.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
219736
MGIiMGI:2684909, Stox1

Phylogenomic databases

eggNOGiKOG3897, Eukaryota
GeneTreeiENSGT00520000055589
HOGENOMiCLU_306723_0_0_1
InParanoidiB2RQL2
OMAiTNPGESQ
OrthoDBi494782at2759
TreeFamiTF337253

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
216021, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Stox1, mouse

Protein Ontology

More...
PROi
PR:B2RQL2
RNActiB2RQL2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036923, Expressed in spermatocyte and 122 other tissues
GenevisibleiB2RQL2, MM

Family and domain databases

InterProiView protein in InterPro
IPR019391, Storkhead-box_winged-helix
IPR040126, STOX1/2
PANTHERiPTHR22437, PTHR22437, 1 hit
PfamiView protein in Pfam
PF10264, Stork_head, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTOX1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RQL2
Secondary accession number(s): Q3UZS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: July 1, 2008
Last modified: June 2, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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