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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

Usp42

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei119NucleophilePROSITE-ProRule annotation1
Active sitei370Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • thiol-dependent ubiquitin-specific protease activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDifferentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
Gene namesi
Name:Usp42
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924050 Usp42

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004041991 – 1324Ubiquitin carboxyl-terminal hydrolase 42Add BLAST1324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei858PhosphoserineCombined sources1
Modified residuei910PhosphoserineCombined sources1
Modified residuei1189PhosphoserineBy similarity1
Modified residuei1227PhosphoserineCombined sources1
Modified residuei1230PhosphoserineCombined sources1
Modified residuei1234PhosphoserineCombined sources1
Modified residuei1255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB2RQC2
MaxQBiB2RQC2
PaxDbiB2RQC2
PeptideAtlasiB2RQC2
PRIDEiB2RQC2

PTM databases

iPTMnetiB2RQC2
PhosphoSitePlusiB2RQC2

Expressioni

Tissue specificityi

Highest expression seen in the testis. Also expressed in brain, lung and thymus. The expression level gradually increases from 2 weeks after birth and then decreases from the pachytene spermatocyte (PS) stage during spermatogenesis.1 Publication

Developmental stagei

Expressed in the midbrain, forebrain, optic vesicles and eyes of embryos at E10.5 and a more pronounced expression is seen at E12.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000051306 Expressed in 241 organ(s), highest expression level in cumulus cell
GenevisibleiB2RQC2 MM

Interactioni

Protein-protein interaction databases

BioGridi218324, 1 interactor
STRINGi10090.ENSMUSP00000053955

Structurei

3D structure databases

ProteinModelPortaliB2RQC2
SMRiB2RQC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 411USPAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1184 – 1254Lys-richAdd BLAST71

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000236355
HOVERGENiHBG080724
InParanoidiB2RQC2
KOiK11855
OMAiCSQPVMN
OrthoDBiEOG091G02D8
PhylomeDBiB2RQC2
TreeFamiTF315281

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

B2RQC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIVDKTEPS DPSTCQNQPG SCEAVSPEDM DTGSASWGAV SSISDVSSHT
60 70 80 90 100
LPLGPVPGAV VYSNSSVPEK SKPSPPKDQV LGDGIAPPQK VLFPSEKICL
110 120 130 140 150
KWQQSHRVGA GLQNLGNTCF ANAALQCLTY TPPLANYMLS HEHSKTCHAE
160 170 180 190 200
GFCMMCTMQT HITQALSNPG DVIKPMFVIN EMRRIARHFR FGNQEDAHEF
210 220 230 240 250
LQYTVDAMQK ACLNGSNKLD RHTQATTLVC QIFGGYLRSR VKCLNCKGVS
260 270 280 290 300
DTFDPYLDIT LEIKAAQSVT KALEQFVKPE QLDGENSYKC SKCKKMVPAS
310 320 330 340 350
KRFTIHRSSN VLTISLKRFA NFTGGKIAKD VKYPEYLDIR PYMSQPNGEP
360 370 380 390 400
IIYVLYAVLV HTGFNCHAGH YFCYIKASNG LWYQMNDSIV STSDIRAVLN
410 420 430 440 450
QQAYVLFYIR SHDVKNGGES AHPAHSPGQS SPRPGVSQRV VNNKQVAPGF
460 470 480 490 500
IGPQLPSHVM KNTPHLNGTT PVKDTPSSSV SSPNGNTSVN RASPATASTS
510 520 530 540 550
VQNWSVTRPS VIPDHPKKQK ITISIHNKLP ARQGQAPLNN SLHGPCLEAP
560 570 580 590 600
SKAAPSSTIT NPSAIQSTSN VPTTSTSPSE ACPKPMVNGK AKVGASVLVP
610 620 630 640 650
YGAESSEESD EESKGLAKEN GVDMMAGTHS DRPEAAADDG AEASSHELQE
660 670 680 690 700
PVLLNGANSA DSDSQENSLA FDSASCQVQP ELHTENLFSK LNGLPGKVTP
710 720 730 740 750
APLQSVPEDR ILETFKLTNQ AKGPAGEESW TTTGGSSPKD PVSQLEPISD
760 770 780 790 800
EPSPLEIPEA VTNGSTQTPS TTSPLEPTIS CTKEDSSVVV SAEPVEGLPS
810 820 830 840 850
VPALCNSTGT ILGDTPVPEL CDPGDLTANP SQPTEAVKGD TAEKAQDSAM
860 870 880 890 900
AEVVERLSPA PSVLTGDGCE QKLLLYLSAE GSEETEDSSR SSAVSADTMP
910 920 930 940 950
PKPDRTTTSS CEGAAEQAAG DRGDGGHVGP KAQEPSPAKE KMSSLRKVDR
960 970 980 990 1000
GHYRSRRERS SSGEHVRDSR PRPEDHHHKK RHCYSRERPK QDRHPTNSYC
1010 1020 1030 1040 1050
NGGQHLGHGD RASPERRSLS RYSHHHSRIR SGLEQDWSRY HHLENEHAWV
1060 1070 1080 1090 1100
RERFYQDKLR WDKCRYYHDR YTPLYTARDA REWRPLHGRE HDRLVQSGRP
1110 1120 1130 1140 1150
YKDSYWGRKG WELQSRGKER PHFNSPREAP SLAVPLERHL QEKAALSVQD
1160 1170 1180 1190 1200
SSHSLPERFH EHKSVKSRKR RYETLENNDG RLEKKVHKSL EKDTLEEPRV
1210 1220 1230 1240 1250
KKHKKSKKKK KSKDKHRDRE SRHQQESDFS GAYSDADLHR HRKKKKKKKR
1260 1270 1280 1290 1300
HSRKSEDFIK DVEMRLPKLS SYEAGGHFRR TEGSFLLADG LPVEDSGPFR
1310 1320
EKTKHLRMES RPDRCRLSEY GQGD
Length:1,324
Mass (Da):146,223
Last modified:July 1, 2008 - v1
Checksum:i5214E845D98C3288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466529 Genomic DNA Translation: EDL19037.1
BC137852 mRNA Translation: AAI37853.1
CCDSiCCDS39372.1
RefSeqiNP_084025.2, NM_029749.2
XP_006504817.1, XM_006504754.3
UniGeneiMm.259620

Genome annotation databases

EnsembliENSMUST00000053287; ENSMUSP00000053955; ENSMUSG00000051306
GeneIDi76800
KEGGimmu:76800
UCSCiuc009akp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466529 Genomic DNA Translation: EDL19037.1
BC137852 mRNA Translation: AAI37853.1
CCDSiCCDS39372.1
RefSeqiNP_084025.2, NM_029749.2
XP_006504817.1, XM_006504754.3
UniGeneiMm.259620

3D structure databases

ProteinModelPortaliB2RQC2
SMRiB2RQC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218324, 1 interactor
STRINGi10090.ENSMUSP00000053955

PTM databases

iPTMnetiB2RQC2
PhosphoSitePlusiB2RQC2

Proteomic databases

EPDiB2RQC2
MaxQBiB2RQC2
PaxDbiB2RQC2
PeptideAtlasiB2RQC2
PRIDEiB2RQC2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053287; ENSMUSP00000053955; ENSMUSG00000051306
GeneIDi76800
KEGGimmu:76800
UCSCiuc009akp.1 mouse

Organism-specific databases

CTDi84132
MGIiMGI:1924050 Usp42

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000236355
HOVERGENiHBG080724
InParanoidiB2RQC2
KOiK11855
OMAiCSQPVMN
OrthoDBiEOG091G02D8
PhylomeDBiB2RQC2
TreeFamiTF315281

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

PROiPR:B2RQC2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051306 Expressed in 241 organ(s), highest expression level in cumulus cell
GenevisibleiB2RQC2 MM

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBP42_MOUSE
AccessioniPrimary (citable) accession number: B2RQC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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