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Protein

Potassium voltage-gated channel subfamily A member 10

Gene

Kcna10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 10Curated
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.8By similarity
Gene namesi
Name:Kcna10Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3037820 Kcna10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei218 – 238Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei271 – 292Helical; Name=Segment S2Sequence analysisAdd BLAST22
Transmembranei303 – 323Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei339 – 358Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST20
Transmembranei375 – 395Helical; Name=Segment S5Sequence analysisAdd BLAST21
Transmembranei436 – 456Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Viable with no gross defects. Vestibular evoked potentials (VsEPs) are highly abnormal suggesting impaired function of the balance organ, although mice do not display any obvious imbalance behaviors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004374601 – 511Potassium voltage-gated channel subfamily A member 10Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi293S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiB2RQA1
PaxDbiB2RQA1
PeptideAtlasiB2RQA1
PRIDEiB2RQA1

PTM databases

PhosphoSitePlusiB2RQA1

Expressioni

Tissue specificityi

Expressed strongly in the inner ear and weakly in skeletal muscle. Not detected in other tissues.1 Publication

Developmental stagei

Detected in the cochlear duct from E14.5 (PubMed:22446089). Detected in the organ of Corti and the vestibular system from E16.5 onwards, where it is most strongly expressed in hair cells (PubMed:22446089, PubMed:23528307).2 Publications

Gene expression databases

BgeeiENSMUSG00000042861 Expressed in 8 organ(s), highest expression level in internal ear

Interactioni

Subunit structurei

Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088118

Structurei

3D structure databases

ProteinModelPortaliB2RQA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi421 – 426Selectivity filterBy similarity6

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.By similarity
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiB2RQA1
KOiK04881
OMAiMCPTTPG
OrthoDBiEOG091G10NU
PhylomeDBiB2RQA1
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

B2RQA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVCSWKEME VALVNFDNSD EIHEEPGYAT DFDPTSSKGR PGSSPFSNWR
60 70 80 90 100
VLISDNTNHE TAFSKIPGEY VDPPGPEPVV LNEGNQRVII NIAGLRFETQ
110 120 130 140 150
LRTLNQFPET LLGDREKRMQ FFDSMRNEYF FDRNRPSFDG ILYYYQSGGK
160 170 180 190 200
IRRPANVPID VFADEISFYE LGSEAMDQFR EDEGFIKDPE TLLPTNDFHR
210 220 230 240 250
QFWLLFEYPE SSSAARGVAV VSVLVVVISI TIFCLETLPE FREDRELKVV
260 270 280 290 300
RDPSINTNKT GLSQTMFTDP FFMVESTCIV WFTFELVLRF VVCPSKTDFF
310 320 330 340 350
KNIMNIIDII SIIPYFATLI TELVQETEPS AQQNMSLAIL RIIRLVRVFR
360 370 380 390 400
IFKLSRHSKG LQILGQTLKA SMRELGLLIF FLFIGVILFS SAVYFAEVDE
410 420 430 440 450
PESHFSSIPD GFWWAVVTMT TVGYGDMCPT TPGGKIVGTL CAIAGVLTIA
460 470 480 490 500
LPVPVIVSNF NYFYHRETEN EEKPNIPGEL DKILNSMGSR MGSTESLNKT
510
NGSCSAEKSR K
Length:511
Mass (Da):57,968
Last modified:July 1, 2008 - v1
Checksum:i31FB404011B4BF29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250V → A in AAI58037 (PubMed:15489334).Curated1
Sequence conflicti479E → S in AAI58037 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121825 Genomic DNA No translation available.
AC132405 Genomic DNA No translation available.
BC137828 mRNA Translation: AAI37829.1
BC137829 mRNA Translation: AAI37830.1
BC158036 mRNA Translation: AAI58037.1
CCDSiCCDS38587.1
RefSeqiNP_001074609.1, NM_001081140.1
UniGeneiMm.245155

Genome annotation databases

EnsembliENSMUST00000055064; ENSMUSP00000088118; ENSMUSG00000042861
GeneIDi242151
KEGGimmu:242151
UCSCiuc008qwt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121825 Genomic DNA No translation available.
AC132405 Genomic DNA No translation available.
BC137828 mRNA Translation: AAI37829.1
BC137829 mRNA Translation: AAI37830.1
BC158036 mRNA Translation: AAI58037.1
CCDSiCCDS38587.1
RefSeqiNP_001074609.1, NM_001081140.1
UniGeneiMm.245155

3D structure databases

ProteinModelPortaliB2RQA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088118

PTM databases

PhosphoSitePlusiB2RQA1

Proteomic databases

MaxQBiB2RQA1
PaxDbiB2RQA1
PeptideAtlasiB2RQA1
PRIDEiB2RQA1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055064; ENSMUSP00000088118; ENSMUSG00000042861
GeneIDi242151
KEGGimmu:242151
UCSCiuc008qwt.1 mouse

Organism-specific databases

CTDi3744
MGIiMGI:3037820 Kcna10

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
HOGENOMiHOG000231015
HOVERGENiHBG052230
InParanoidiB2RQA1
KOiK04881
OMAiMCPTTPG
OrthoDBiEOG091G10NU
PhylomeDBiB2RQA1
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Miscellaneous databases

PROiPR:B2RQA1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042861 Expressed in 8 organ(s), highest expression level in internal ear

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCA10_MOUSE
AccessioniPrimary (citable) accession number: B2RQA1
Secondary accession number(s): B2RXZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2016
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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