Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

Abl2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-428890 Role of ABL in ROBO-SLIT signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:Abl2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:87860 Abl2

Expressioni

Gene expression databases

BgeeiENSMUSG00000026596 Expressed in 240 organ(s), highest expression level in secondary oocyte

Interactioni

Protein-protein interaction databases

IntActiB2RQ57, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 167SH3InterPro annotationAdd BLAST61
Domaini173 – 263SH2InterPro annotationAdd BLAST91
Domaini288 – 539Protein kinaseInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000119011
HOVERGENiHBG004162
KOiK08887

Family and domain databases

CDDicd09935 SH2_ABL, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035837 ABL_SH2
IPR015015 F-actin_binding
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF08919 F_actin_bind, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00808 FABD, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

B2RQ57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TADAGFNVFT
60 70 80 90 100
QHDHFASCVE DGFEGDKTGG SSPEVLHRPF GCDAESQALN EAIRWSSKEN
110 120 130 140 150
LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS
160 170 180 190 200
KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES
210 220 230 240 250
ESSPGQLSIS LRYEGRVYHY RINTTTDSKV YVTAESRFST LAELVHHHST
260 270 280 290 300
VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
310 320 330 340 350
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV
360 370 380 390 400
CTLEPPFYIV TEYMPYGNLL DYLRECSREE VTAVVLLYMA TQISSAMEYL
410 420 430 440 450
EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK
460 470 480 490 500
WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK
510 520 530 540 550
GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE
560 570 580 590 600
EVAEELGRTA SSSSVVPYLP RLPLLPSKTR TLRKQGENKE NLDGGLDAAE
610 620 630 640 650
SLASSSAPAG FIRSTQASSG SPALPRKQRD KSPSSLLEDA KETCFTRDRK
660 670 680 690 700
GGFFSSFMKK RNAPTPPKRS SSFREMENQP HKKYELTGLP EQDRMAMTLP
710 720 730 740 750
RNCQRSKLQL ERTVSTSSQP EENVDRANDM LPKKSEEGAA PARERPKAKL
760 770 780 790 800
LPRGATALPL RAPDPAITES DSPGVGVAGV AAAPKGKERN GGTRLGVAGV
810 820 830 840 850
PEDGEQLGWS SPAKAVAVLP TTHNHKVPVL ISPTLKHTPA DVQLIGTDSQ
860 870 880 890 900
GNKFKLLSEH QVTSSGDKDR PRRVKPKCAP PPPPVMRLLQ HPSTCSDPEE
910 920 930 940 950
EPTAPPAGQH TPETQEGGKK AAPGPMPSSG KPGRPVMPPP QVPLPTSSIS
960 970 980 990 1000
PAKMANGTAG TKVALRKTKQ AAEKISADKI SKEALLECAD LLSSAITEPV
1010 1020 1030 1040 1050
PNSQLVDTGH QLLDYCSGYV DSIPQTRNKF AFREAVSKLE LSLQELQVSS
1060 1070
TAAGVPGTNP VLNNLLSCVQ EISDVVQR
Length:1,078
Mass (Da):117,766
Last modified:July 1, 2008 - v1
Checksum:i7CF6AA48C100E1F4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4JIM5ABL2_MOUSE
Tyrosine-protein kinase ABL2
Abl2 Arg
1,182Annotation score:
F8VQH0F8VQH0_MOUSE
Tyrosine-protein kinase
Abl2
1,182Annotation score:
A0A087WQB7A0A087WQB7_MOUSE
Tyrosine-protein kinase ABL2
Abl2
269Annotation score:
G3UWQ2G3UWQ2_MOUSE
Tyrosine-protein kinase ABL2
Abl2
139Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114588 Genomic DNA No translation available.
AC145078 Genomic DNA No translation available.
BC137771 mRNA Translation: AAI37772.1
RefSeqiNP_001129576.1, NM_001136104.1
NP_033725.2, NM_009595.3
UniGeneiMm.329515

Genome annotation databases

EnsembliENSMUST00000166172; ENSMUSP00000126181; ENSMUSG00000026596
GeneIDi11352
KEGGimmu:11352
UCSCiuc011wuf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiB2RQ57_MOUSE
AccessioniPrimary (citable) accession number: B2RQ57
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again