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Protein

Multimerin-1

Gene

Mmrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: InterPro
  • positive regulation of cell-substrate adhesion Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Multimerin-1Imported
Gene namesi
Name:Mmrn1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918195 Mmrn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000036703920 – 1210Multimerin-1Sequence analysisAdd BLAST1191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi196 ↔ 257Sequence analysis
Disulfide bondi222 ↔ 230Sequence analysis
Disulfide bondi256 ↔ 265Sequence analysis
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi712N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi810N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi822N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi903N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi963N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1027 ↔ 1038Sequence analysis
Disulfide bondi1032 ↔ 1047Sequence analysis
Disulfide bondi1049 ↔ 1058Sequence analysis

Post-translational modificationi

Extensively N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiB2RPV6
PaxDbiB2RPV6
PeptideAtlasiB2RPV6
PRIDEiB2RPV6

PTM databases

iPTMnetiB2RPV6
PhosphoSitePlusiB2RPV6

Interactioni

Subunit structurei

Multimeric. Composed of varying sized, disulfide-linked multimers, the smallest of which is a homotrimer. Proteolysis of the promultimerin in the N-terminal region, leads to the mature p155 form that is stored in platelets. Interacts with factor V/Va (By similarity).By similarity

Protein-protein interaction databases

ComplexPortaliCPX-447 Multimerin-1 complex

Structurei

3D structure databases

ProteinModelPortaliB2RPV6
SMRiB2RPV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 267EMIPROSITE-ProRule annotationAdd BLAST76
Domaini1023 – 1059EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini1078 – 1210C1qPROSITE-ProRule annotationAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili303 – 338Sequence analysisAdd BLAST36
Coiled coili564 – 690Sequence analysisAdd BLAST127
Coiled coili809 – 846Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coil, EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IEM1 Eukaryota
ENOG411182X LUCA
HOGENOMiHOG000213370
HOVERGENiHBG108139
InParanoidiB2RPV6

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011489 EMI_domain
IPR033188 MMRN1
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR15427:SF3 PTHR15427:SF3, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF00008 EGF, 1 hit
PF07546 EMI, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS51041 EMI, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: B2RPV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGLKFLVLL SILWGRVFRL TNTQHSWTAP KDEDASLTPN HASASVSEIL
60 70 80 90 100
SLQVLSATQN PSTQGPAAAE RSSEDDVLLQ STSQPSETST PPEGRHQTPL
110 120 130 140 150
EKTGTAVVSL PLSLQDKPSI KPSTGAGTVM LANATLKFLQ SFSRKSDQQE
160 170 180 190 200
VSTKSAGDMG NRSARETHLR RSDNSRNQRP SYQKPSFETT RGKNWCAHVH
210 220 230 240 250
TKLSPTVILD TGSHLPSGRG SCGWYSSGLC SRRSQKTSNA VYRMQHKIVT
260 270 280 290 300
SLEWRCCPGY IGPNCQLKVE EQQQLAHSNQ AESHTAVDQG RAQQQKQDCG
310 320 330 340 350
DPAMIQKLAE QLSQQERKLS LLQKKVDNAS LVADDMRNAY LSLEGKVGED
360 370 380 390 400
NSRQFQSFLK ALKSKSIEDL LKNIVKEQFK VFQDDMQETT AQIFKTVSSL
410 420 430 440 450
SEDLESTRQA VLQVNQSFVS STAQKDFAFM QENQPTWKDI TDLKNSIMNI
460 470 480 490 500
RQEMALTCEK PVKELEAKQA HLEGALRQEH SQIVLYHQSL NETLSKMQEA
510 520 530 540 550
HIQLLSVLQV SGTENVATEE SLNSNVTKYI SVLQETASKQ GLMLLQMLSD
560 570 580 590 600
LHVQESKISN LTILLEMEKE SARGECEEML SKCRHDFKFQ LKDTEENLHV
610 620 630 640 650
LNQTLSEVIF PMDIKVDKMS EQLNDLTYDM EILQPLLEQR SSLQHQVIHK
660 670 680 690 700
PKEATVTRRE LQNLIGAINQ LNVLTKELTK RHNLLRNEVQ SRGEAFERRI
710 720 730 740 750
SEHALETEDG LNKTMTVINN AIDFVQDNYV LKETLSAMTY NPKVCECNQN
760 770 780 790 800
MDNILTFVSE FQHLNDSIQT LVNNKEKYNF ILQIAKALTA IPKDEKLNQL
810 820 830 840 850
NFQNIYQLFN ETTSQVNKCQ QNMSHLEENM LSVTKTAKEF ETRLQGIESK
860 870 880 890 900
VTKTLIPYYI SFKKGGILSN ERDVDLQLKV LNTRFKALEA KSIHLSVSFS
910 920 930 940 950
LLNKTVRELS MACRNASTGT CGQNALIPRW TKGSLPGSQS SQKSLTELVE
960 970 980 990 1000
SIVEIKTQAA LSNLTWNVDR LLSDTLANIV KPQKQIKLQK KPNTLKKTVN
1010 1020 1030 1040 1050
MTTILIGRTQ RNTDTIIHPV AQEHSSCSSF PCQNGGTCIS GRSNFICACR
1060 1070 1080 1090 1100
HPFMGDTCTV KIKEDDAVAP DFSKGSYRYA PMVAFFVSHT HGMTAPGPIL
1110 1120 1130 1140 1150
FNDLSVNYGA SYNPRTGKFR IPYLGVYIFK YTIESFSAHI SGFFVVDGVD
1160 1170 1180 1190 1200
KLRFESENAD NEIHCDRVLT GDALFELNYG QEVWLRLVKG TIPIKYPPVT
1210
TFSGYLLYRT
Length:1,210
Mass (Da):136,106
Last modified:March 24, 2009 - v2
Checksum:i971CBB31F6827DD5
GO
Isoform 21 Publication (identifier: B2RPV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-1210: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:193
Mass (Da):20,946
Checksum:i55E4A1FC381D5460
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UVV6G3UVV6_MOUSE
MCG123217
Mmrn1 mCG_123217
1,210Annotation score:
A0A0N4SVL8A0A0N4SVL8_MOUSE
Multimerin-1
Mmrn1
1,209Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41H → P in BAB29654 (PubMed:16141072).Curated1
Sequence conflicti93E → D in BAB29654 (PubMed:16141072).Curated1
Sequence conflicti96H → S in BAB29654 (PubMed:16141072).Curated1
Sequence conflicti99P → S in BAB29654 (PubMed:16141072).Curated1
Sequence conflicti110L → M in BAB29654 (PubMed:16141072).Curated1
Sequence conflicti935L → V in AAI37624 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053049194 – 1210Missing in isoform 2. 1 PublicationAdd BLAST1017

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014984 mRNA Translation: BAB29654.1
BC046425 mRNA Translation: AAH46425.1
BC137623 mRNA Translation: AAI37624.1
AJ586616 mRNA Translation: CAE52464.1
CCDSiCCDS51799.1 [B2RPV6-1]
RefSeqiNP_001156979.1, NM_001163507.1
NP_081889.1, NM_027613.1
UniGeneiMm.389770

Genome annotation databases

GeneIDi70945
KEGGimmu:70945
UCSCiuc009cdq.1 mouse [B2RPV6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014984 mRNA Translation: BAB29654.1
BC046425 mRNA Translation: AAH46425.1
BC137623 mRNA Translation: AAI37624.1
AJ586616 mRNA Translation: CAE52464.1
CCDSiCCDS51799.1 [B2RPV6-1]
RefSeqiNP_001156979.1, NM_001163507.1
NP_081889.1, NM_027613.1
UniGeneiMm.389770

3D structure databases

ProteinModelPortaliB2RPV6
SMRiB2RPV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-447 Multimerin-1 complex

PTM databases

iPTMnetiB2RPV6
PhosphoSitePlusiB2RPV6

Proteomic databases

MaxQBiB2RPV6
PaxDbiB2RPV6
PeptideAtlasiB2RPV6
PRIDEiB2RPV6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi70945
KEGGimmu:70945
UCSCiuc009cdq.1 mouse [B2RPV6-2]

Organism-specific databases

CTDi22915
MGIiMGI:1918195 Mmrn1

Phylogenomic databases

eggNOGiENOG410IEM1 Eukaryota
ENOG411182X LUCA
HOGENOMiHOG000213370
HOVERGENiHBG108139
InParanoidiB2RPV6

Miscellaneous databases

PROiPR:B2RPV6
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR011489 EMI_domain
IPR033188 MMRN1
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR15427:SF3 PTHR15427:SF3, 1 hit
PfamiView protein in Pfam
PF00386 C1q, 1 hit
PF00008 EGF, 1 hit
PF07546 EMI, 1 hit
PRINTSiPR00007 COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110 C1Q, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS51041 EMI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMRN1_MOUSE
AccessioniPrimary (citable) accession number: B2RPV6
Secondary accession number(s): Q6KDN2, Q80VQ7, Q9D5S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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