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Protein

Olfactory receptor 11H12

Gene

OR11H12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 11H12
Gene namesi
Name:OR11H12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000257115.1
HGNCiHGNC:30738 OR11H12
neXtProtiNX_B2RN74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 112ExtracellularSequence analysisAdd BLAST19
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini134 – 158CytoplasmicSequence analysisAdd BLAST25
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 216ExtracellularSequence analysisAdd BLAST37
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 259CytoplasmicSequence analysisAdd BLAST22
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 287ExtracellularSequence analysis7
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 326CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671220

Polymorphism and mutation databases

BioMutaiOR11H12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003447981 – 326Olfactory receptor 11H12Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 194PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB2RN74
PRIDEiB2RN74
ProteomicsDBi3441

Expressioni

Gene expression databases

BgeeiENSG00000257115 Expressed in 2 organ(s), highest expression level in blood
CleanExiHS_OR11H12

Organism-specific databases

HPAiHPA047370

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000449002

Structurei

3D structure databases

ProteinModelPortaliB2RN74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiB2RN74
KOiK04257
OMAiKLVIICW
OrthoDBiEOG091G0AZH
PhylomeDBiB2RN74

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2RN74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPLTLQVTG LMNVSEPNSS FAFVNEFILQ GFTCEWTIQI FLFSLFTTTY
60 70 80 90 100
ALTITGNGAI AFVLWCDWRL HTPMYMFLGN FSFLEIWYVS STVPKMLVNF
110 120 130 140 150
LSEKKNISFA GCFLQFYFFF SLGTSECLLL TVMAFDQYLA ICRPLLYPNI
160 170 180 190 200
MTGHLCAKLV ILCWVCGFLW FLIPIVLISQ MPFCGPNIID HVVCDPGPRF
210 220 230 240 250
ALDCVSAPRI QLFCYTLSSL VIFGNFLFII GSYTLVLKAV LGMPSSTGRH
260 270 280 290 300
KAFSTCGSHL AVVSLCYSSL MVMYVSPGLG HSTGMQKIET LFYAMVTPLF
310 320
NPLIYSLQNK EIKAALRKVL GSSNII
Length:326
Mass (Da):36,530
Last modified:July 1, 2008 - v1
Checksum:iF616037020AB0550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136730 mRNA Translation: AAI36731.1
BC136731 mRNA Translation: AAI36732.1
CCDSiCCDS32017.1
RefSeqiNP_001013372.1, NM_001013354.1
UniGeneiHs.534880

Genome annotation databases

EnsembliENST00000550708; ENSP00000449002; ENSG00000257115
GeneIDi440153
KEGGihsa:440153
UCSCiuc010tkp.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136730 mRNA Translation: AAI36731.1
BC136731 mRNA Translation: AAI36732.1
CCDSiCCDS32017.1
RefSeqiNP_001013372.1, NM_001013354.1
UniGeneiHs.534880

3D structure databases

ProteinModelPortaliB2RN74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000449002

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR11H12

Proteomic databases

PaxDbiB2RN74
PRIDEiB2RN74
ProteomicsDBi3441

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550708; ENSP00000449002; ENSG00000257115
GeneIDi440153
KEGGihsa:440153
UCSCiuc010tkp.3 human

Organism-specific databases

CTDi440153
EuPathDBiHostDB:ENSG00000257115.1
GeneCardsiOR11H12
HGNCiHGNC:30738 OR11H12
HPAiHPA047370
neXtProtiNX_B2RN74
PharmGKBiPA142671220
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFEZ Eukaryota
ENOG411183S LUCA
GeneTreeiENSGT00890000139362
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiB2RN74
KOiK04257
OMAiKLVIICW
OrthoDBiEOG091G0AZH
PhylomeDBiB2RN74

Miscellaneous databases

GenomeRNAii440153
PROiPR:B2RN74

Gene expression databases

BgeeiENSG00000257115 Expressed in 2 organ(s), highest expression level in blood
CleanExiHS_OR11H12

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO11HC_HUMAN
AccessioniPrimary (citable) accession number: B2RN74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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