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Protein

Prolyl tripeptidyl peptidase

Gene

ptpA

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position (By similarity).By similarity

Catalytic activityi

Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei603Charge relay systemBy similarity1
Active sitei678Charge relay systemBy similarity1
Active sitei710Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciPGIN431947:G1G2V-1314-MONOMER

Protein family/group databases

ESTHERiporgi-q7muw6 DPP4N_Peptidase_S9
MEROPSiS09.017

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl tripeptidyl peptidaseBy similarity (EC:3.4.14.12)
Short name:
PTPBy similarity
Alternative name(s):
Prolyl tripeptidyl peptidase ABy similarity
Gene namesi
Name:ptpABy similarity
Ordered Locus Names:PGN_1149
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000039475925 – 732Prolyl tripeptidyl peptidaseSequence analysisAdd BLAST708

Proteomic databases

PRIDEiB2RJX3

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_1149

Structurei

3D structure databases

ProteinModelPortaliB2RJX3
SMRiB2RJX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C5Z Bacteria
COG1506 LUCA
HOGENOMiHOG000290580
KOiK18574
OMAiVIYNIHT

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2RJX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTIFQQLF LSVCALTVAL PCSAQSPETS GKEFTLEQLM PGGKEFYNFY
60 70 80 90 100
PEYVVGLQWM GDNYVFIEGD DLVFNKANGK SAQTTRFSAA DLNALMPEGC
110 120 130 140 150
KFQTTDAFPS FRTLDAGRGQ VVLFTQRGLV GFDMLARKVT YLFDTNEETA
160 170 180 190 200
SLDFSPVGDR VAYVRNHNLY IARGGKLGEG MSRAIAVTID GAETLVYGQA
210 220 230 240 250
VHQREFGIEK GTFWSPKGSC LAFYRMDQSM VKPTPIVDYH PLEAESKPLY
260 270 280 290 300
YPMAGTPSHH VTVGIYHLAT GKTVYLQTGE PKEKFLTNLS WSPDENILYV
310 320 330 340 350
AEVNRAQNEC KVNAYDAETG RFVRTLFVET DKHYVEPLHP LTFLPGSNNQ
360 370 380 390 400
FIWQSRRDGW NHLYLYDTTG RLIRQVTKGE WEVTNFAGFD PKGTRLYFES
410 420 430 440 450
TEASPLERHF YCIDIKGGKT KDLTPESGMH RTQLSPDGSA IIDIFQSPTV
460 470 480 490 500
PRKVTVTNIG KGSYTLLEAK NPDTGYAMPE IRTGTIMAAD GQTPLYYKLT
510 520 530 540 550
MPLHFDPAKK YPVIVYVYGG PHAQLVTKTW RSSVGGWDIY MAQKGYAVFT
560 570 580 590 600
VDSRGSANRG AAFEQVIHRR LGQTEMADQM CGVDFLKSQS WVDADRIGVH
610 620 630 640 650
GWSYGGFMTT NLMLTHGDVF KVGVAGGPVI DWNRYEIMYG ERYFDAPQEN
660 670 680 690 700
PEGYDAANLL KRAGDLKGRL MLIHGAIDPV VVWQHSLLFL DACVKARTYP
710 720 730
DYYVYPSHEH NVMGPDRVHL YETITRYFTD HL
Length:732
Mass (Da):82,376
Last modified:July 1, 2008 - v1
Checksum:iAE1162049B59CD27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009380 Genomic DNA Translation: BAG33668.1
RefSeqiWP_012458062.1, NZ_CP025930.1

Genome annotation databases

EnsemblBacteriaiBAG33668; BAG33668; PGN_1149
GeneIDi29256355
KEGGipgn:PGN_1149

Similar proteinsi

Entry informationi

Entry nameiPTP_PORG3
AccessioniPrimary (citable) accession number: B2RJX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 1, 2008
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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