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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.By similarity

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.By similarity

Activity regulationi

Allosterically activated by GTP.By similarity

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei815-phospho-alpha-D-ribose 1-diphosphateBy similarity1
Binding sitei1065-phospho-alpha-D-ribose 1-diphosphateBy similarity1
Binding sitei200Uracil; via amide nitrogenBy similarity1
Binding sitei2065-phospho-alpha-D-ribose 1-diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene namesi
Name:upp
Ordered Locus Names:PGN_0779
OrganismiPorphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Taxonomic identifieri431947 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000008842 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003706951 – 216Uracil phosphoribosyltransferaseAdd BLAST216

Proteomic databases

PRIDEiB2RIV3

Interactioni

Protein-protein interaction databases

STRINGi431947.PGN_0779

Structurei

3D structure databases

ProteinModelPortaliB2RIV3
SMRiB2RIV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 1435-phospho-alpha-D-ribose 1-diphosphate bindingBy similarity9
Regioni205 – 207Uracil bindingBy similarity3

Sequence similaritiesi

Belongs to the UPRTase family.Curated

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
HOGENOMiHOG000262755
KOiK00761
OMAiRICGYEI

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

B2RIV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVIHLGAEH SLLNRFVMEM RDVTIQNDRL RFRRNIERVG EVMAYEISKK
60 70 80 90 100
MTQQVRTVTT PLGEAECSVP QDKVVLATIL RAGLPFHHGF LNYFDYCENA
110 120 130 140 150
FVSAYRKYKD RLNFDIHIEY IASPDITDKV LIISDPMLAT GSSMELAYKA
160 170 180 190 200
LLTKGNPKHI HIASIIASQQ AVDYIRGVMP DNTTIWIAAI DPTIDEHSYI
210
VPGLGDAGDL AYGEKL
Length:216
Mass (Da):24,371
Last modified:July 1, 2008 - v1
Checksum:i7FA62BD4CFA1DFD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016085 Genomic DNA Translation: BAA36601.1
AP009380 Genomic DNA Translation: BAG33298.1
RefSeqiWP_004585294.1, NZ_CP025930.1

Genome annotation databases

EnsemblBacteriaiBAG33298; BAG33298; PGN_0779
GeneIDi29255998
KEGGipgn:PGN_0779

Similar proteinsi

Entry informationi

Entry nameiUPP_PORG3
AccessioniPrimary (citable) accession number: B2RIV3
Secondary accession number(s): Q9ZNF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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