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UniProtKB - B2RE43 (B2RE43_HUMAN)

Entry version 73 (02 Dec 2020)
Sequence version 1 (01 Jul 2008)
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Protein
Submitted name:

cDNA, FLJ96916, highly similar to Homo sapiens netrin 4 (NTN4), mRNA

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cDNA, FLJ96916, highly similar to Homo sapiens netrin 4 (NTN4), mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500278154919 – 628Sequence analysisAdd BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi295 ↔ 304PROSITE-ProRule annotation
Disulfide bondi362 ↔ 371PROSITE-ProRule annotation
Disulfide bondi422 ↔ 431PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		B2RE43

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 261Laminin N-terminalInterPro annotationAdd BLAST232
Domaini262 – 331Laminin EGF-likeInterPro annotationAdd BLAST70
Domaini332 – 394Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini395 – 448Laminin EGF-likeInterPro annotationAdd BLAST54
Domaini506 – 627NTRInterPro annotationAdd BLAST122

Keywords - Domaini

Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Family and domain databases

Conserved Domains Database

More...CDDi		cd03578, NTR_netrin-4_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.50.120, 1 hit
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002049, Laminin_EGF
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR035811, Netrin-4_NTR
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 3 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RE43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSCARLLLL WGCTVVAAGL SGVAGVSSRC EKACNPRMGN LALGRKLWAD 
        60         70         80         90        100
TTCGQNATEL YCFYSENTDL TCRQPKCDKC NAAYPHLAHL PSAMADSSFR 
       110        120        130        140        150
FPRTWWQSAE DVHREKIQLD LEAEFYFTHL IVMFKSPRPA AMVLDRSQDF 
       160        170        180        190        200
GKTWKPYKYF ATNCSATFGL EDDVVKKGAI CTSKYSSPFP CTGGEVIFKA 
       210        220        230        240        250
LSPPYDTENP YSAKVQEQLK ITNLRVQLLK RQSCPCQRND LNEEPQHFTH 
       260        270        280        290        300
YAIYDFIVKG SCFCNGHADQ CIPVHGFRPV KAPGTFHMVH GKCMCKHNTA 
       310        320        330        340        350
GSHCQHCAPL YNDRPWEAAD GKTGAPNECR TCKCNGHADT CHFDVNVWEA 
       360        370        380        390        400
SGNRSGGVCD DCQHNTEGQY CQRCKPGFYR DLRRPFSAPD ACKPCSCHPV 
       410        420        430        440        450
GSAVLPANSV TFCDPSNGDC PCKPGVAGRR CDRCMVGYWG FGDYGCRPCD 
       460        470        480        490        500
CAGSCDPITG DCISSHTDID WYHEVPDFRP VHNKSEPAWE WEDAQGFSAL 
       510        520        530        540        550
LHSGKCECKE QTLGNAKAFC GMKYSYVLKI KILSAHDKGT HVEVNVKIKM 
       560        570        580        590        600
VLKSTKLKIF RGKRTLYPES WTDRGCTCPI LNPGLEYLVA GHEDIRTGKL 
       610        620 
IVNMKSFVQH WKPSLGRKVM DILKRECK
Length:628
Mass (Da):70,074
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC72CC4D1A39B5FE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK315796 mRNA Translation: BAG38140.1

NCBI Reference Sequences

More...RefSeqi		NP_001316629.1, NM_001329700.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		59277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315796 mRNA Translation: BAG38140.1
RefSeqiNP_001316629.1, NM_001329700.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiB2RE43

Genome annotation databases

GeneIDi59277

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		59277

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		59277, 4 hits in 841 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		59277

Family and domain databases

CDDicd03578, NTR_netrin-4_like, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR002049, Laminin_EGF
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
IPR035811, Netrin-4_NTR
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008993, TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053, Laminin_EGF, 3 hits
PF00055, Laminin_N, 1 hit
PF01759, NTR, 1 hit
SMARTiView protein in SMART
SM00643, C345C, 1 hit
SM00180, EGF_Lam, 3 hits
SM00136, LamNT, 1 hit
SUPFAMiSSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 3 hits
PS51117, LAMININ_NTER, 1 hit
PS50189, NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RE43_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RE43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: December 2, 2020
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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