UniProtKB - B2RE43 (B2RE43_HUMAN)
Protein
Submitted name:
cDNA, FLJ96916, highly similar to Homo sapiens netrin 4 (NTN4), mRNA
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Names & Taxonomyi
Protein namesi | Submitted name: cDNA, FLJ96916, highly similar to Homo sapiens netrin 4 (NTN4), mRNAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5002781549 | 19 – 628 | Sequence analysisAdd BLAST | 610 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 295 ↔ 304 | PROSITE-ProRule annotation | ||
Disulfide bondi | 362 ↔ 371 | PROSITE-ProRule annotation | ||
Disulfide bondi | 422 ↔ 431 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | B2RE43 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 261 | Laminin N-terminalInterPro annotationAdd BLAST | 232 | |
Domaini | 262 – 331 | Laminin EGF-likeInterPro annotationAdd BLAST | 70 | |
Domaini | 332 – 394 | Laminin EGF-likeInterPro annotationAdd BLAST | 63 | |
Domaini | 395 – 448 | Laminin EGF-likeInterPro annotationAdd BLAST | 54 | |
Domaini | 506 – 627 | NTRInterPro annotationAdd BLAST | 122 |
Keywords - Domaini
Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisFamily and domain databases
CDDi | cd03578, NTR_netrin-4_like, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR002049, Laminin_EGF IPR008211, Laminin_N IPR038684, Laminin_N_sf IPR035811, Netrin-4_NTR IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 3 hits PF00055, Laminin_N, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00180, EGF_Lam, 3 hits SM00136, LamNT, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 3 hits PS51117, LAMININ_NTER, 1 hit PS50189, NTR, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RE43-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSCARLLLL WGCTVVAAGL SGVAGVSSRC EKACNPRMGN LALGRKLWAD
60 70 80 90 100
TTCGQNATEL YCFYSENTDL TCRQPKCDKC NAAYPHLAHL PSAMADSSFR
110 120 130 140 150
FPRTWWQSAE DVHREKIQLD LEAEFYFTHL IVMFKSPRPA AMVLDRSQDF
160 170 180 190 200
GKTWKPYKYF ATNCSATFGL EDDVVKKGAI CTSKYSSPFP CTGGEVIFKA
210 220 230 240 250
LSPPYDTENP YSAKVQEQLK ITNLRVQLLK RQSCPCQRND LNEEPQHFTH
260 270 280 290 300
YAIYDFIVKG SCFCNGHADQ CIPVHGFRPV KAPGTFHMVH GKCMCKHNTA
310 320 330 340 350
GSHCQHCAPL YNDRPWEAAD GKTGAPNECR TCKCNGHADT CHFDVNVWEA
360 370 380 390 400
SGNRSGGVCD DCQHNTEGQY CQRCKPGFYR DLRRPFSAPD ACKPCSCHPV
410 420 430 440 450
GSAVLPANSV TFCDPSNGDC PCKPGVAGRR CDRCMVGYWG FGDYGCRPCD
460 470 480 490 500
CAGSCDPITG DCISSHTDID WYHEVPDFRP VHNKSEPAWE WEDAQGFSAL
510 520 530 540 550
LHSGKCECKE QTLGNAKAFC GMKYSYVLKI KILSAHDKGT HVEVNVKIKM
560 570 580 590 600
VLKSTKLKIF RGKRTLYPES WTDRGCTCPI LNPGLEYLVA GHEDIRTGKL
610 620
IVNMKSFVQH WKPSLGRKVM DILKRECK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315796 mRNA Translation: BAG38140.1 |
RefSeqi | NP_001316629.1, NM_001329700.1 |
Genome annotation databases
GeneIDi | 59277 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315796 mRNA Translation: BAG38140.1 |
RefSeqi | NP_001316629.1, NM_001329700.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B2RE43 |
Genome annotation databases
GeneIDi | 59277 |
Organism-specific databases
CTDi | 59277 |
Miscellaneous databases
BioGRID-ORCSi | 59277, 4 hits in 841 CRISPR screens |
GenomeRNAii | 59277 |
Family and domain databases
CDDi | cd03578, NTR_netrin-4_like, 1 hit |
Gene3Di | 2.40.50.120, 1 hit 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR002049, Laminin_EGF IPR008211, Laminin_N IPR038684, Laminin_N_sf IPR035811, Netrin-4_NTR IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 3 hits PF00055, Laminin_N, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00180, EGF_Lam, 3 hits SM00136, LamNT, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS01248, EGF_LAM_1, 1 hit PS50027, EGF_LAM_2, 3 hits PS51117, LAMININ_NTER, 1 hit PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RE43_HUMAN | |
Accessioni | B2RE43Primary (citable) accession number: B2RE43 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |