UniProtKB - B2RD01 (CENP1_HUMAN)
Protein
CENPB DNA-binding domain-containing protein 1
Gene
CENPBD1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 40 – 60 | H-T-H motifBy similarityAdd BLAST | 21 | |
DNA bindingi | 111 – 148 | H-T-H motifBy similarityAdd BLAST | 38 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | B2RD01 |
Names & Taxonomyi
Protein namesi | Recommended name: CENPB DNA-binding domain-containing protein 1 |
Gene namesi | Name:CENPBD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28272, CENPBD1 |
neXtProti | NX_B2RD01 |
VEuPathDBi | HostDB:ENSG00000177946.5 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 92806 |
OpenTargetsi | ENSG00000177946 |
PharmGKBi | PA165449826 |
Miscellaneous databases
Pharosi | B2RD01, Tdark |
Genetic variation databases
BioMutai | CENPBD1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000394661 | 1 – 187 | CENPB DNA-binding domain-containing protein 1Add BLAST | 187 |
Proteomic databases
MassIVEi | B2RD01 |
PaxDbi | B2RD01 |
PeptideAtlasi | B2RD01 |
PRIDEi | B2RD01 |
ProteomicsDBi | 3425 |
PTM databases
iPTMneti | B2RD01 |
PhosphoSitePlusi | B2RD01 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177946, Expressed in amniotic fluid and 209 other tissues |
Genevisiblei | B2RD01, HS |
Organism-specific databases
HPAi | ENSG00000177946, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124980, 1 interactor |
STRINGi | 9606.ENSP00000393854 |
Miscellaneous databases
RNActi | B2RD01, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 64 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 78 – 155 | HTH CENPB-typePROSITE-ProRule annotationAdd BLAST | 78 |
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000163154 |
HOGENOMi | CLU_018294_6_2_1 |
InParanoidi | B2RD01 |
OMAi | RERKVIT |
OrthoDBi | 1343623at2759 |
PhylomeDBi | B2RD01 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RD01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGERPTDAT VIPSAKRERK AITLDLKLEV LRRFEAGEKL SQIAKALDLA
60 70 80 90 100
ISTVATIRDS KEKIKASSQI ATPLRASRLT RHRSAVMESM EQLLSLWLED
110 120 130 140 150
QSQPNATLSA AIVQEKAEFD DLQREHGEGS QTERFHASQG WLVRFKECHC
160 170 180
LPHFKMNSAA PSNKDMYTEM LKSIIEEGEY TPQVSLT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 168 | T → I in BC009263 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315352 mRNA Translation: BAG37748.1 AC092143 Genomic DNA No translation available. BC009263 mRNA No translation available. |
CCDSi | CCDS45556.1 |
RefSeqi | NP_659476.2, NM_145039.3 |
Genome annotation databases
Ensembli | ENST00000314994; ENSP00000393854; ENSG00000177946 |
GeneIDi | 92806 |
KEGGi | hsa:92806 |
UCSCi | uc002fpr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315352 mRNA Translation: BAG37748.1 AC092143 Genomic DNA No translation available. BC009263 mRNA No translation available. |
CCDSi | CCDS45556.1 |
RefSeqi | NP_659476.2, NM_145039.3 |
3D structure databases
SMRi | B2RD01 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124980, 1 interactor |
STRINGi | 9606.ENSP00000393854 |
PTM databases
iPTMneti | B2RD01 |
PhosphoSitePlusi | B2RD01 |
Genetic variation databases
BioMutai | CENPBD1 |
Proteomic databases
MassIVEi | B2RD01 |
PaxDbi | B2RD01 |
PeptideAtlasi | B2RD01 |
PRIDEi | B2RD01 |
ProteomicsDBi | 3425 |
Protocols and materials databases
Antibodypediai | 57219, 24 antibodies |
DNASUi | 92806 |
Genome annotation databases
Ensembli | ENST00000314994; ENSP00000393854; ENSG00000177946 |
GeneIDi | 92806 |
KEGGi | hsa:92806 |
UCSCi | uc002fpr.4, human |
Organism-specific databases
CTDi | 92806 |
DisGeNETi | 92806 |
GeneCardsi | CENPBD1 |
HGNCi | HGNC:28272, CENPBD1 |
HPAi | ENSG00000177946, Low tissue specificity |
neXtProti | NX_B2RD01 |
OpenTargetsi | ENSG00000177946 |
PharmGKBi | PA165449826 |
VEuPathDBi | HostDB:ENSG00000177946.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000163154 |
HOGENOMi | CLU_018294_6_2_1 |
InParanoidi | B2RD01 |
OMAi | RERKVIT |
OrthoDBi | 1343623at2759 |
PhylomeDBi | B2RD01 |
Enzyme and pathway databases
PathwayCommonsi | B2RD01 |
Miscellaneous databases
BioGRID-ORCSi | 92806, 4 hits in 993 CRISPR screens |
GenomeRNAii | 92806 |
Pharosi | B2RD01, Tdark |
PROi | PR:B2RD01 |
RNActi | B2RD01, protein |
Gene expression databases
Bgeei | ENSG00000177946, Expressed in amniotic fluid and 209 other tissues |
Genevisiblei | B2RD01, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CENP1_HUMAN | |
Accessioni | B2RD01Primary (citable) accession number: B2RD01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | July 1, 2008 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM