UniProtKB - B2RBY1 (B2RBY1_HUMAN)
Protein
Interleukin-4 receptor subunit alpha
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytokine receptor activity Source: InterPro
GO - Biological processi
- production of molecular mediator involved in inflammatory response Source: InterPro
Keywordsi
Molecular function | ReceptorImportedARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-4 receptor subunit alphaARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5002779564 | 24 – 825 | Interleukin-4 receptor subunit alphaSequence analysisAdd BLAST | 802 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | B2RBY1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 224 | Fibronectin type-IIIInterPro annotationAdd BLAST | 100 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 373 – 397 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 433 – 485 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 651 – 703 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 782 – 809 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 381 – 397 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 784 – 809 | PolarSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
OrthoDBi | 476828at2759 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015319, IL-4_rcpt-alpha_N |
Pfami | View protein in Pfam PF09238, IL4Ra_N, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RBY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG
60 70 80 90 100
PTNCSTELRL LYQLVFLLSE AHTCVPENNG GAGCVCHLLM DDVVSADNYT
110 120 130 140 150
LDLWAGQQLL WKGSFKPSEH VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD
160 170 180 190 200
NYLYNHLTYA VNIWSENDPA DFRIYNVTYL EPSLRIAAST LKSGISYRAR
210 220 230 240 250
VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS CIVILAVCLL
260 270 280 290 300
CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
310 320 330 340 350
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV
360 370 380 390 400
LWPESISVVR CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE
410 420 430 440 450
GIVARLTESL FLDLLGEENG GFCQQDMGES CLLPPSGSTS AHMPWDEFPS
460 470 480 490 500
AGPKEAPPWG KEQPLHLEPS PPASPTQSPD NLTCTETPLV IAGNPAYRSF
510 520 530 540 550
SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT TVPQPEPETW
560 570 580 590 600
EQILRRNVLQ HGAAAAPVSA PTSGYREFVH AVEQGGTQAS AVVGLGPPGE
610 620 630 640 650
AGYKAFSSLL ASRAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV
660 670 680 690 700
PLFTFGLDRE PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT
710 720 730 740 750
DPLVDSLGSG IVYSALTCHL CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD
760 770 780 790 800
RSSPPTTPLR APDPSPGGVP LEASLCPASL APSGISEKSK SSSSFHPAPG
810 820
NAQSSSQTPK IVNFVSVGPT YMRVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK314863 mRNA Translation: BAG37378.1 |
RefSeqi | NP_001244335.1, NM_001257406.1 |
Genome annotation databases
GeneIDi | 3566 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK314863 mRNA Translation: BAG37378.1 |
RefSeqi | NP_001244335.1, NM_001257406.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B2RBY1 |
Genome annotation databases
GeneIDi | 3566 |
Organism-specific databases
CTDi | 3566 |
Phylogenomic databases
OrthoDBi | 476828at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3566, 3 hits in 876 CRISPR screens |
GenomeRNAii | 3566 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003531, Hempt_rcpt_S_F1_CS IPR013783, Ig-like_fold IPR015319, IL-4_rcpt-alpha_N |
Pfami | View protein in Pfam PF09238, IL4Ra_N, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS01355, HEMATOPO_REC_S_F1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RBY1_HUMAN | |
Accessioni | B2RBY1Primary (citable) accession number: B2RBY1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |