We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - B2RB89 (B2RB89_HUMAN)
Protein
cAMP-dependent protein kinase
Gene
PRKACB
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 73 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- AMP-activated protein kinase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-UniRule
- cAMP-dependent protein kinase activity Source: UniProtKB-EC
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotationARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, cAMPARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PRKACBImported ORF Names:hCG_23660Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000142875 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142875, Expressed in caudate nucleus and 255 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 298 | Protein kinaseInterPro annotationAdd BLAST | 255 | |
Domaini | 299 – 351 | AGC-kinase C-terminalInterPro annotationAdd BLAST | 53 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.ARBA annotation
Phylogenomic databases
OrthoDBi | 963519at2759 |
Family and domain databases
CDDi | cd14209, STKc_PKA, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044109, STKc_PKA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RB89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL
60 70 80 90 100
GTGSFGRVML VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN
110 120 130 140 150
FPFLVRLEYA FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ
160 170 180 190 200
IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY IQVTDFGFAK RVKGRTWTLC
210 220 230 240 250
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK
260 270 280 290 300
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT
310 320 330 340 350
TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE
F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK314550 mRNA Translation: BAG37136.1 AB451239 mRNA Translation: BAG70053.1 AB451364 mRNA Translation: BAG70178.1 CH471097 Genomic DNA Translation: EAW73247.1 CH471097 Genomic DNA Translation: EAW73249.1 |
RefSeqi | NP_002722.1, NM_002731.3 |
Genome annotation databases
GeneIDi | 5567 |
KEGGi | hsa:5567 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK314550 mRNA Translation: BAG37136.1 AB451239 mRNA Translation: BAG70053.1 AB451364 mRNA Translation: BAG70178.1 CH471097 Genomic DNA Translation: EAW73247.1 CH471097 Genomic DNA Translation: EAW73249.1 |
RefSeqi | NP_002722.1, NM_002731.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B2RB89, 2 interactors |
Protocols and materials databases
Antibodypediai | 4160, 410 antibodies from 36 providers |
DNASUi | 5567 |
Genome annotation databases
GeneIDi | 5567 |
KEGGi | hsa:5567 |
Organism-specific databases
CTDi | 5567 |
PharmGKBi | PA33749 |
VEuPathDBi | HostDB:ENSG00000142875 |
Phylogenomic databases
OrthoDBi | 963519at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5567, 9 hits in 1075 CRISPR screens |
ChiTaRSi | PRKACB, human |
GenomeRNAii | 5567 |
Gene expression databases
Bgeei | ENSG00000142875, Expressed in caudate nucleus and 255 other tissues |
Family and domain databases
CDDi | cd14209, STKc_PKA, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR044109, STKc_PKA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RB89_HUMAN | |
Accessioni | B2RB89Primary (citable) accession number: B2RB89 Secondary accession number(s): D3DT10 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | January 19, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |