UniProtKB - B2R9N9 (B2R9N9_HUMAN)
Protein
Submitted name:
TLR7
Gene
TLR7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- drug binding Source: Ensembl
- single-stranded RNA binding Source: Ensembl
- siRNA binding Source: Ensembl
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- defense response to virus Source: Ensembl
- innate immune response Source: UniProtKB-KW
- microglial cell activation Source: Ensembl
- positive regulation of interferon-alpha production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- regulation of protein phosphorylation Source: Ensembl
- toll-like receptor 7 signaling pathway Source: Ensembl
Keywordsi
Molecular function | ReceptorImportedARBA annotation |
Biological process | Immunity, Inflammatory responseARBA annotation, Innate immunityARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: TLR7ImportedSubmitted name: Toll-like receptor 7ImportedSubmitted name: cDNA, FLJ94489, Homo sapiens toll-like receptor 7 (TLR7), mRNAImported |
Gene namesi | Name:TLR7Imported ORF Names:hCG_1646600Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000196664.4 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Endosome
- endosome Source: Ensembl
Lysosome
- lysosome Source: Ensembl
Other locations
- early phagosome Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 840 – 865 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000196664, Expressed in leukocyte and 131 other tissues |
ExpressionAtlasi | B2R9N9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 891 – 1036 | TIRInterPro annotationAdd BLAST | 146 |
Sequence similaritiesi
Belongs to the Toll-like receptor family.ARBA annotation
Keywords - Domaini
Leucine-rich repeatARBA annotation, RepeatARBA annotation, SignalARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
HOGENOMi | CLU_006000_2_0_1 |
OMAi | DPAVSEW |
OrthoDBi | 303561at2759 |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit |
Pfami | View protein in Pfam PF13306, LRR_5, 1 hit PF13855, LRR_8, 3 hits PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 18 hits PS50104, TIR, 1 hit |
i Sequence
Sequence statusi: Complete.
B2R9N9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVFPMWTLKR QILILFNIIL ISKLLGARWF PKTLPCDVTL DVPKNHVIVD
60 70 80 90 100
CTDKHLTEIP GGIPTNTTNL TLTINHIPDI SPASFHRLDH LVEIDFRCNC
110 120 130 140 150
VPIPLGSKNN MCIKRLQIKP RSFSGLTYLK SLYLDGNQLL EIPQGLPPSL
160 170 180 190 200
QLLSLEANNI FSIRKENLTE LANIEILYLG QNCYYRNPCY VSYSIEKDAF
210 220 230 240 250
LNLTKLKVLS LKDNNVTAVP TVLPSTLTEL YLYNNMIAKI QEDDFNNLNQ
260 270 280 290 300
LQILDLSGNC PRCYNAPFPC APCKNNSPLQ IPVNAFDALT ELKVLRLHSN
310 320 330 340 350
SLQHVPPRWF KNINKLQELD LSQNFLAKEI GDAKFLHFLP SLIQLDLSFN
360 370 380 390 400
FELQVYRASM NLSQAFSSLK SLKILRIRGY VFKELKSFNL SPLHNLQNLE
410 420 430 440 450
VLDLGTNFIK IANLSMFKQF KRLKVIDLSV NKISPSGDSS EVGFCSNART
460 470 480 490 500
SVESYEPQVL EQLHYFRYDK YARSCRFKNK EASFMSVNES CYKYGQTLDL
510 520 530 540 550
SKNSIFFVKS SDFQHLSFLK CLNLSGNLIS QTLNGSEFQP LAELRYLDFS
560 570 580 590 600
NNRLDLLHST AFEELHKLEV LDISSNSHYF QSEGITHMLN FTKNLKVLQK
610 620 630 640 650
LMMNDNDISS STSRTMESES LRTLEFRGNH LDVLWREGDN RYLQLFKNLL
660 670 680 690 700
KLEELDISKN SLSFLPSGVF DGMPPNLKNL SLAKNGLKSF SWKKLQCLKN
710 720 730 740 750
LETLDLSHNQ LTTVPERLSN CSRSLKNLIL KNNQIRSLTK YFLQDAFQLR
760 770 780 790 800
YLDLSSNKIQ MIQKTSFPEN VLNNLKMLLL HHNRFLCTCD AVWFVWWVNH
810 820 830 840 850
TEVTIPYLAT DVTCVGPGAH KGQSVISLDL YTCELDLTNL ILFSLSISVS
860 870 880 890 900
LFLMVMMTAS HLYFWDVWYI YHFCKAKIKG YQRLISPDCC YDAFIVYDTK
910 920 930 940 950
DPAVTEWVLA ELVAKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS
960 970 980 990 1000
KKTVFVMTDK YAKTENFKIA FYLSHQRLMD EKVDVIILIF LEKPFQKSKF
1010 1020 1030 1040
LQLRKRLCGS SVLEWPTNPQ AHPYFWQCLK NALATDNHVA YSQVFKETV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ022180 Genomic DNA Translation: AAZ99021.1 DQ022181 Genomic DNA Translation: AAZ99022.1 DQ022182 Genomic DNA Translation: AAZ99023.1 DQ022183 Genomic DNA Translation: AAZ99024.1 AK313858 mRNA Translation: BAG36586.1 AB445659 mRNA Translation: BAG55056.1 CH471074 Genomic DNA Translation: EAW98807.1 |
RefSeqi | NP_057646.1, NM_016562.3 |
Genome annotation databases
GeneIDi | 51284 |
KEGGi | hsa:51284 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ022180 Genomic DNA Translation: AAZ99021.1 DQ022181 Genomic DNA Translation: AAZ99022.1 DQ022182 Genomic DNA Translation: AAZ99023.1 DQ022183 Genomic DNA Translation: AAZ99024.1 AK313858 mRNA Translation: BAG36586.1 AB445659 mRNA Translation: BAG55056.1 CH471074 Genomic DNA Translation: EAW98807.1 |
RefSeqi | NP_057646.1, NM_016562.3 |
3D structure databases
SMRi | B2R9N9 |
ModBasei | Search... |
Chemistry databases
BindingDBi | B2R9N9 |
Protocols and materials databases
Antibodypediai | 8500, 977 antibodies |
DNASUi | 51284 |
Genome annotation databases
GeneIDi | 51284 |
KEGGi | hsa:51284 |
Organism-specific databases
CTDi | 51284 |
PharmGKBi | PA38008 |
VEuPathDBi | HostDB:ENSG00000196664.4 |
Phylogenomic databases
HOGENOMi | CLU_006000_2_0_1 |
OMAi | DPAVSEW |
OrthoDBi | 303561at2759 |
Miscellaneous databases
BioGRID-ORCSi | 51284, 5 hits in 502 CRISPR screens |
ChiTaRSi | TLR7, human |
GenomeRNAii | 51284 |
Gene expression databases
Bgeei | ENSG00000196664, Expressed in leukocyte and 131 other tissues |
ExpressionAtlasi | B2R9N9, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.10140, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR24365, PTHR24365, 1 hit |
Pfami | View protein in Pfam PF13306, LRR_5, 1 hit PF13855, LRR_8, 3 hits PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 12 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 18 hits PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2R9N9_HUMAN | |
Accessioni | B2R9N9Primary (citable) accession number: B2R9N9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | February 10, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |