UniProtKB - B2R6K1 (B2R6K1_HUMAN)
Protein
Methylmalonyl-CoA isomerase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:5.4.99.2ARBA annotation
Cofactori
adenosylcob(III)alaminARBA annotation
GO - Molecular functioni
- cobalamin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- methylmalonyl-CoA mutase activity Source: UniProtKB-EC
Keywordsi
Molecular function | IsomeraseARBA annotation |
Ligand | CobalaminARBA annotation, Cobalt, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Methylmalonyl-CoA isomeraseARBA annotation (EC:5.4.99.2ARBA annotation)Alternative name(s): Methylmalonyl-CoA mutase, mitochondrialARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 614 – 746 | B12-bindingInterPro annotationAdd BLAST | 133 |
Sequence similaritiesi
Belongs to the methylmalonyl-CoA mutase family.ARBA annotation
Phylogenomic databases
OrthoDBi | 347581at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006159, Acid_CoA_mut_C IPR016176, Cbl-dep_enz_cat IPR006158, Cobalamin-bd IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR006098, MMCoA_mutase_a_cat |
Pfami | View protein in Pfam PF02310, B12-binding, 1 hit PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00640, acid_CoA_mut_C, 1 hit TIGR00641, acid_CoA_mut_N, 1 hit |
PROSITEi | View protein in PROSITE PS51332, B12_BINDING, 1 hit PS00544, METMALONYL_COA_MUTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
B2R6K1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRAKNQLFL LSPHYLRQVK ESSGSRLIQQ RLLHQQQPLH PEWAALAKKQ
60 70 80 90 100
LKGKNPEDLI WHTPEGISIK PLYSKRDTMD LPEELPGVKP FTRGPYPTMY
110 120 130 140 150
TFRPWTIRQY AGFSTVEEGN KFYKDNIKAG QQGLSVAFDL ATHRGYDSDN
160 170 180 190 200
PRVRGDVGMA GVAIDTVEDT KILFDGIPLE KMSVSMTMNG AVIPVLANFI
210 220 230 240 250
VTGEEQGVPK EKLTGTIQND ILKEFMVRNT YIFPPEPSMK IIADIFEYTA
260 270 280 290 300
KHMPKFNSIS ISGYHMQEAG ADAILELAYT LADGLEYSRT GLQAGLTIDE
310 320 330 340 350
FAPRLSFFWG IGMNFYMEIA KMRAGRRLWA HLIEKMFQPK NSKSLLLRAH
360 370 380 390 400
CQTSGWSLTE QDPYNNIVRT AIEAMAAVFG GTQSLHTNSF DEALGLPTVK
410 420 430 440 450
SARIARNTQI IIQEESGIPK VADPWGGSYM MECLTNDVYD AALKLINEIE
460 470 480 490 500
EMGGMAKAVA EGIPKLRIEE CAARRQARID SGSEVIVGVN KYQLEKEDAV
510 520 530 540 550
EVLAIDNTSV RNRQIEKLKK IKSSRDQALA ERCLAALTEC AASGDGNILA
560 570 580 590 600
LAVDASRARC TVGEITDALK KVFGEHKAND RMVSGAYRQG FGESKEITSA
610 620 630 640 650
IKRVHKFMER EGRRPRLLVA KMGQDGHDRG AKVIATGFAD LGFDVDIGPL
660 670 680 690 700
FQTPREVAQQ AVDADVHAVG ISTLAAGHKT LVPELIKELN SLGRPDILVM
710 720 730 740 750
CGGVIPPQDY EFLFEVGVSN VFGPGTRIPK AAVQVLDDIE KCLEKKQQSV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312611 mRNA Translation: BAG35498.1 |
RefSeqi | NP_000246.2, NM_000255.3 |
Genome annotation databases
GeneIDi | 4594 |
KEGGi | hsa:4594 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312611 mRNA Translation: BAG35498.1 |
RefSeqi | NP_000246.2, NM_000255.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B2R6K1, 1 interactor |
Proteomic databases
PeptideAtlasi | B2R6K1 |
Protocols and materials databases
DNASUi | 4594 |
Genome annotation databases
GeneIDi | 4594 |
KEGGi | hsa:4594 |
Organism-specific databases
CTDi | 4594 |
Phylogenomic databases
OrthoDBi | 347581at2759 |
Miscellaneous databases
BioGRID-ORCSi | 4594, 4 hits in 844 CRISPR screens |
GenomeRNAii | 4594 |
Gene expression databases
Genevisiblei | B2R6K1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006159, Acid_CoA_mut_C IPR016176, Cbl-dep_enz_cat IPR006158, Cobalamin-bd IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR006098, MMCoA_mutase_a_cat |
Pfami | View protein in Pfam PF02310, B12-binding, 1 hit PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00640, acid_CoA_mut_C, 1 hit TIGR00641, acid_CoA_mut_N, 1 hit |
PROSITEi | View protein in PROSITE PS51332, B12_BINDING, 1 hit PS00544, METMALONYL_COA_MUTASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2R6K1_HUMAN | |
Accessioni | B2R6K1Primary (citable) accession number: B2R6K1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |