We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - B2R6F3 (B2R6F3_HUMAN)
Protein
Submitted name:
Epididymis secretory sperm binding protein
Gene
SFRS3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- phospholipase binding Source: Ensembl
- RNA binding Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: Ensembl
Keywordsi
Molecular function | RNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Epididymis secretory sperm binding proteinImportedSubmitted name: Splicing factor arginine/serine-rich 3ImportedSubmitted name: Splicing factor, arginine/serine-rich 3, isoform CRA_dImportedSubmitted name: cDNA, FLJ92926, Homo sapiens splicing factor, arginine/serine-rich 3 (SFRS3), mRNAImported |
Gene namesi | Name:SFRS3Imported ORF Names:hCG_14802Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000112081 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112081, Expressed in testis and 251 other tissues |
Interactioni
GO - Molecular functioni
- phospholipase binding Source: Ensembl
Protein-protein interaction databases
IntActi | B2R6F3, 1 interactor |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 83 | RRMInterPro annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 81 – 164 | DisorderedSequence analysisAdd BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 109 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 110 – 124 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 125 – 164 | Basic and acidic residuesSequence analysisAdd BLAST | 40 |
Phylogenomic databases
HOGENOMi | CLU_012062_20_2_1 |
OMAi | EMHRDSC |
OrthoDBi | 1533297at2759 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
B2R6F3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRDSCPLDC KVYVGNLGNN GNKTELERAF GYYGPLRSVW VARNPPGFAF
60 70 80 90 100
VEFEDPRDAA DAVRELDGRT LCGCRVRVEL SNGEKRSRNR GPPPSWGRRP
110 120 130 140 150
RDDYRRRSPP PRRRSPRRRS FSRSRSRSLS RDRRRERSLS RERNHKPSRS
160
FSRSRSRSRS NERK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891426 mRNA Translation: ADO22288.1 AK312553 mRNA Translation: BAG35450.1 AB451229 mRNA Translation: BAG70043.1 AB451352 mRNA Translation: BAG70166.1 CH471081 Genomic DNA Translation: EAX03901.1 CH471081 Genomic DNA Translation: EAX03903.1 |
RefSeqi | NP_003008.1, NM_003017.4 |
Genome annotation databases
GeneIDi | 6428 |
KEGGi | hsa:6428 |
MANE-Selecti | ENST00000373715.11; ENSP00000362820.5; NM_003017.5; NP_003008.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ891426 mRNA Translation: ADO22288.1 AK312553 mRNA Translation: BAG35450.1 AB451229 mRNA Translation: BAG70043.1 AB451352 mRNA Translation: BAG70166.1 CH471081 Genomic DNA Translation: EAX03901.1 CH471081 Genomic DNA Translation: EAX03903.1 |
RefSeqi | NP_003008.1, NM_003017.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B2R6F3, 1 interactor |
Protocols and materials databases
Antibodypediai | 29693, 284 antibodies from 31 providers |
DNASUi | 6428 |
Genome annotation databases
GeneIDi | 6428 |
KEGGi | hsa:6428 |
MANE-Selecti | ENST00000373715.11; ENSP00000362820.5; NM_003017.5; NP_003008.1 |
Organism-specific databases
CTDi | 6428 |
PharmGKBi | PA35701 |
VEuPathDBi | HostDB:ENSG00000112081 |
Phylogenomic databases
HOGENOMi | CLU_012062_20_2_1 |
OMAi | EMHRDSC |
OrthoDBi | 1533297at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6428, 808 hits in 1082 CRISPR screens |
ChiTaRSi | SRSF3, human |
GenomeRNAii | 6428 |
Gene expression databases
Bgeei | ENSG00000112081, Expressed in testis and 251 other tissues |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2R6F3_HUMAN | |
Accessioni | B2R6F3Primary (citable) accession number: B2R6F3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |