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Protein

Histone H2B

Gene

HIST1H2BF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2BUniRule annotation
Gene namesi
Name:HIST1H2BFImported
Synonyms:HIST1H2BCImported, HIST1H2BEImported, HIST1H2BGImported, HIST1H2BIImported
ORF Names:hCG_1640484Imported, hCG_1640985Imported, hCG_1641780Imported, hCG_1787353Imported, hCG_1787365Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000276410.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29132

Expressioni

Gene expression databases

BgeeiENSG00000276410 Expressed in 68 organ(s), highest expression level in lung

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 101HistoneInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the histone H2B family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
HOGENOMiHOG000231213
HOVERGENiHBG007774
KOiK11252
OMAiTMAANDI
OrthoDBiEOG091G0XGD

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

B2R4S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:July 1, 2008 - v1
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311935 mRNA Translation: BAG34876.1
AK312096 mRNA Translation: BAG35032.1
CH471087 Genomic DNA Translation: EAW55530.1
CH471087 Genomic DNA Translation: EAW55531.1
CH471087 Genomic DNA Translation: EAW55537.1
CH471087 Genomic DNA Translation: EAW55543.1
CH471087 Genomic DNA Translation: EAW55545.1
CH471087 Genomic DNA Translation: EAW55554.1
RefSeqiNP_003509.1, NM_003518.3
NP_003513.1, NM_003522.3
NP_003514.2, NM_003523.2
NP_003516.1, NM_003525.2
NP_003517.2, NM_003526.2
UniGeneiHs.182137
Hs.534369
Hs.553506
Hs.591797
Hs.591809
Hs.658713
Hs.726509

Genome annotation databases

GeneIDi8339
8343
8344
8346
8347
KEGGihsa:8339
hsa:8343
hsa:8344
hsa:8346
hsa:8347

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311935 mRNA Translation: BAG34876.1
AK312096 mRNA Translation: BAG35032.1
CH471087 Genomic DNA Translation: EAW55530.1
CH471087 Genomic DNA Translation: EAW55531.1
CH471087 Genomic DNA Translation: EAW55537.1
CH471087 Genomic DNA Translation: EAW55543.1
CH471087 Genomic DNA Translation: EAW55545.1
CH471087 Genomic DNA Translation: EAW55554.1
RefSeqiNP_003509.1, NM_003518.3
NP_003513.1, NM_003522.3
NP_003514.2, NM_003523.2
NP_003516.1, NM_003525.2
NP_003517.2, NM_003526.2
UniGeneiHs.182137
Hs.534369
Hs.553506
Hs.591797
Hs.591809
Hs.658713
Hs.726509

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi8339
8344
8347
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8339
8343
8344
8346
8347
KEGGihsa:8339
hsa:8343
hsa:8344
hsa:8346
hsa:8347

Organism-specific databases

CTDi8339
8343
8344
8346
8347
EuPathDBiHostDB:ENSG00000276410.2
PharmGKBiPA29132

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
HOGENOMiHOG000231213
HOVERGENiHBG007774
KOiK11252
OMAiTMAANDI
OrthoDBiEOG091G0XGD

Miscellaneous databases

ChiTaRSiHIST1H2BC human

Gene expression databases

BgeeiENSG00000276410 Expressed in 68 organ(s), highest expression level in lung

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2R4S9_HUMAN
AccessioniPrimary (citable) accession number: B2R4S9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 10, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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