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UniProtKB - B2NI93 (GEDH_CARLC)
Protein
Geraniol dehydrogenase
Gene
gedh
Organism
Carpoglyphus lactis (Dried fruit mite) (Acarus lactis)
Status
Functioni
Catalyzes the NAD+-dependent oxidation of geraniol to geranial, playing an important role in the biosynthesis of neral, an alarm pheromone. Cannot use NADP+. Also acts as a farnesol dehydrogenase by catalyzing the oxidation of (2E,6E)-farnesol to (2E,6E)-farnesal, with lower activity compared to geraniol dehydrogenase activity.
1 PublicationCatalytic activityi
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Kineticsi
- KM=51.0 µM for geraniol1 Publication
- KM=59.5 µM for NAD+1 Publication
pH dependencei
Optimum pH is 9.0.1 Publication
Temperature dependencei
Optimum temperature is 25 degrees Celsius.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 48 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 75 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 105 | Zinc 2By similarity | 1 | |
Metal bindingi | 108 | Zinc 2By similarity | 1 | |
Metal bindingi | 111 | Zinc 2By similarity | 1 | |
Metal bindingi | 119 | Zinc 2By similarity | 1 | |
Metal bindingi | 179 | Zinc 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gedh1 Publication |
Organismi | Carpoglyphus lactis (Dried fruit mite) (Acarus lactis)Imported |
Taxonomic identifieri | 223459 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Hemisarcoptoidea › Carpoglyphidae › Carpoglyphus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000430710 | 1 – 378 | Geraniol dehydrogenaseAdd BLAST | 378 |
Interactioni
Subunit structurei
Monomer.
1 PublicationFamily & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
B2NI93-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VQNPGASAIQ CRAAVLRKEG QPMKIEQVLI QAPGPNQVRV KMVSSGLCAT
60 70 80 90 100
DAHLVWGEQK ISDLGGIGCP AIAGHEGAGI VESVGENVTE FVPGDSVLTS
110 120 130 140 150
FQPQCGQCES CLRPSTNICK KYDLIKSTTD VSTARTLDGQ PITSLFGLGV
160 170 180 190 200
YSEYITTTEH HVFKVNKAAN LEHASIISCS VGTGFYSATN LAAVYEGSTC
210 220 230 240 250
AVWGLGGIGI NTLFGCKYNK AKHIIGIDVN EDKREIAAEF GCTEFINPKT
260 270 280 290 300
LGQPVEQYLM DKFGGVDFAF DCVGYKPILD QAAVSLAIDG TMVIIGAAAK
310 320 330 340 350
EVKFEMPAFN FLFNRKVVGG LLGSKKTKVA YQELCDMYVD GTYDVDRLVS
360 370
NKFSLDQINE AFQTLKDGNC IRSIVVFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB305641 mRNA Translation: BAG32342.1 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB305641 mRNA Translation: BAG32342.1 |
3D structure databases
SMRi | B2NI93 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 2 hits SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GEDH_CARLC | |
Accessioni | B2NI93Primary (citable) accession number: B2NI93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 29, 2014 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 23, 2022 | |
This is version 47 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families