Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carnocyclin-A

Gene

cclA

Organism
Carnobacterium maltaromaticum (Carnobacterium piscicola)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cyclopeptide antibiotic that inhibits the growth of Gram-positive bacteria, but has no effect on the growth of Gram-negative bacteria.1 Publication

pH dependencei

Stable from pH 2 to 12.1 Publication

Temperature dependencei

Displays a high degree of stability when incubated at temperatures between -80 and 75 degrees Celsius for 60 minutes. Autoclaving the peptide at 121 degrees Celsius for 15 minutes had no effect but incubation at 100 degrees Celsius for 60 minutes caused a 32-fold reduction in activity.1 Publication

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.90.1.1 the carnocyclin a (carnocyclin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Carnocyclin-A
Gene namesi
Name:cclAImported
OrganismiCarnobacterium maltaromaticum (Carnobacterium piscicola)
Taxonomic identifieri2751 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesCarnobacteriaceaeCarnobacterium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003616961 – 41 Publication4
PeptideiPRO_00003616975 – 64Carnocyclin-AAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5 ↔ 64Cyclopeptide (Leu-Leu)1 Publication

Proteomic databases

PRIDEiB2MVM5

Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiB2MVM5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB2MVM5

Family & Domainsi

Family and domain databases

Gene3Di1.20.225.10, 1 hit
InterProiView protein in InterPro
IPR009086 Bacteriocin_AS48
IPR020038 Bacteriocin_uberolysin_fam
PfamiView protein in Pfam
PF09221 Bacteriocin_IId, 1 hit
TIGRFAMsiTIGR03651 circ_ocin_uber, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2MVM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLYELVAYGI AQGTAEKVVS LINAGLTVGS IISILGGVTV GLSGVFTAVK
60
AAIAKQGIKK AIQL
Length:64
Mass (Da):6,417
Last modified:June 10, 2008 - v1
Checksum:i141B4BEF7FE9E56C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32I → L AA sequence (PubMed:18552180).Curated1

Mass spectrometryi

Molecular mass is 5862 Da from positions 5 - 64. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU624394 Genomic DNA Translation: ACC93994.1

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU624394 Genomic DNA Translation: ACC93994.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJFNMR-A5-64[»]
SMRiB2MVM5
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.90.1.1 the carnocyclin a (carnocyclin) family

Proteomic databases

PRIDEiB2MVM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiB2MVM5

Family and domain databases

Gene3Di1.20.225.10, 1 hit
InterProiView protein in InterPro
IPR009086 Bacteriocin_AS48
IPR020038 Bacteriocin_uberolysin_fam
PfamiView protein in Pfam
PF09221 Bacteriocin_IId, 1 hit
TIGRFAMsiTIGR03651 circ_ocin_uber, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCLA_CARML
AccessioniPrimary (citable) accession number: B2MVM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again