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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Elusimicrobium minutum (strain Pei191)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96NucleophileUniRule annotation1
Active sitei121UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciEMIN445932:G1GBV-796-MONOMER

Protein family/group databases

MEROPSiS14.001

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotation
Ordered Locus Names:Emin_0766
OrganismiElusimicrobium minutum (strain Pei191)
Taxonomic identifieri445932 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaElusimicrobiaElusimicrobialesElusimicrobiaceaeElusimicrobium
Proteomesi
  • UP000001029 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002061501 – 195ATP-dependent Clp protease proteolytic subunitAdd BLAST195

Proteomic databases

PRIDEiB2KCS5

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi445932.Emin_0766

Structurei

3D structure databases

SMRiB2KCS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ Bacteria
COG0740 LUCA
HOGENOMiHOG000285833
KOiK01358
OMAiLFLQSEN
OrthoDBiPOG091H01WN

Family and domain databases

CDDicd07017 S14_ClpP_2, 1 hit
HAMAPiMF_00444 ClpP, 1 hit
InterProiView protein in InterPro
IPR001907 ClpP
IPR029045 ClpP/crotonase-like_dom_sf
IPR023562 ClpP/TepA
IPR033135 ClpP_His_AS
PANTHERiPTHR10381 PTHR10381, 1 hit
PfamiView protein in Pfam
PF00574 CLP_protease, 1 hit
PRINTSiPR00127 CLPPROTEASEP
SUPFAMiSSF52096 SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00382 CLP_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

B2KCS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIPTIIEKN VGYDIFSRLL KDRIIFVGGR EGEVDTASAT MIIAQLLYLD
60 70 80 90 100
AEDSEREINL YINSPGGLVT AGLAIYDTMQ FIKAPITTIC MGQAMSFGAV
110 120 130 140 150
LLAAGSKGKR YALPHARIMI HQPLIWGGGI SGQVTDIEIE SNELRKNKEH
160 170 180 190
LLDILAHHTG QDKEKIRQDS ERNYYMSAQE AKAYGLIDEV LDLKK
Length:195
Mass (Da):21,652
Last modified:June 10, 2008 - v1
Checksum:i2EDE253E3B6C2114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001055 Genomic DNA Translation: ACC98321.1
RefSeqiWP_012414936.1, NC_010644.1

Genome annotation databases

EnsemblBacteriaiACC98321; ACC98321; Emin_0766
KEGGiemi:Emin_0766

Similar proteinsi

Entry informationi

Entry nameiCLPP_ELUMP
AccessioniPrimary (citable) accession number: B2KCS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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