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Entry version 67 (31 Jul 2019)
Sequence version 1 (10 Jun 2008)
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Protein
Submitted name:

Neuraminidase, putative

Gene

nanC

Organism
Streptococcus pneumoniae (strain CGSP14)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SPNE516950:G1GBQ-915-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM40 Carbohydrate-Binding Module Family 40
GH33 Glycoside Hydrolase Family 33

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neuraminidase, putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nanCImported
Ordered Locus Names:SPCG_0853Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniae (strain CGSP14)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri516950 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001682 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500277890028 – 740Sequence analysisAdd BLAST713

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 269SialidaseInterPro annotationAdd BLAST172
Domaini501 – 703SialidaseInterPro annotationAdd BLAST203

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 84DisorderedSequence analysisAdd BLAST39

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285031

KEGG Orthology (KO)

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KOi
K01186

Identification of Orthologs from Complete Genome Data

More...
OMAi
DAPNHIN

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002860 BNR_rpt
IPR013320 ConA-like_dom_sf
IPR004124 Glyco_hydro_33_N
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
IPR023364 Trans_sialidase_dom3

The PANTHER Classification System

More...
PANTHERi
PTHR10628 PTHR10628, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02012 BNR, 1 hit
PF13088 BNR_2, 1 hit
PF02973 Sialidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2IP34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKNIKQYVT LGTAVVLSAF VANSVAAQET ETSEVSTPEL VQPVAPTTPI
60 70 80 90 100
SEVQPKSGNS SEVTVQPRTV ETTVKDPSSA TEETPVLEKN NVTLTGGGEN
110 120 130 140 150
VTNELKDKFT SGDFTVVIKY NQSSEKGLQA LFGISNSKPG QQNSYVDVFL
160 170 180 190 200
RDNGELGMEA RDTSSNKNHL VSRPASVWGK YKQEAVTNTV AVVADSVKKT
210 220 230 240 250
YSLYANGTKV VEKKVDNFLN IKDIKGIDYY MLGGVKRAGK TAFGFNGTLE
260 270 280 290 300
NIKFFNSALD EETVKKMTTN AVTGHLIYTA NDTTGSNYFR IPVLYTFSNG
310 320 330 340 350
RVFSSIDARY GGTHDFLNKI NIATSYSDDN GKTWTKPKLT LAFDDFAPVP
360 370 380 390 400
LEWPCDVGGR DLQISGGATY IDSVIVEKNN KQVLMFADVM PAGVSFREAT
410 420 430 440 450
RKDSGYKQID GNYYLKLKKQ GDTDYNYTIR ENGTVYDDRT NRPTEFSVDK
460 470 480 490 500
NFGIKQNGNY LTVEQYSVSF KNNKKTEYRN GTHVHMNIFY KDALFKVVPT
510 520 530 540 550
NYIAYISSND HGESWSAPTL LPPIMGLNRN APYLGPGRGI IESSTGRILI
560 570 580 590 600
PSYTGKESAF IYSDDNGASW KVKVVPLPSS WSAEAQFVEL SPGVIQAYMR
610 620 630 640 650
TNNGKIAYLT STDAGTTWSA PEYLKFVSNP SYGTQLSIIN YSQLIDGKKA
660 670 680 690 700
VILSTPNSTN GRKHGQIWIG LINDDNTIDW RYHHDVDYSN YGYSYSTLTE
710 720 730 740
LPNHEIGLMF EKFDSWSRNE LHMKNVVPYI TFKIEDLKKN
Length:740
Mass (Da):82,260
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9697B2A39CF98867
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP001033 Genomic DNA Translation: ACB90105.1

NCBI Reference Sequences

More...
RefSeqi
WP_000739353.1, NC_010582.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACB90105; ACB90105; SPCG_0853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spw:SPCG_0853

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001033 Genomic DNA Translation: ACB90105.1
RefSeqiWP_000739353.1, NC_010582.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiCBM40 Carbohydrate-Binding Module Family 40
GH33 Glycoside Hydrolase Family 33

Genome annotation databases

EnsemblBacteriaiACB90105; ACB90105; SPCG_0853
KEGGispw:SPCG_0853

Phylogenomic databases

HOGENOMiHOG000285031
KOiK01186
OMAiDAPNHIN

Enzyme and pathway databases

BioCyciSPNE516950:G1GBQ-915-MONOMER

Family and domain databases

Gene3Di2.40.220.10, 1 hit
InterProiView protein in InterPro
IPR002860 BNR_rpt
IPR013320 ConA-like_dom_sf
IPR004124 Glyco_hydro_33_N
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
IPR023364 Trans_sialidase_dom3
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF02012 BNR, 1 hit
PF13088 BNR_2, 1 hit
PF02973 Sialidase, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2IP34_STRPS
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2IP34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: July 31, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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