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Protein

3-ketoacyl-CoA thiolase

Gene

fadA

Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Acyl-thioester intermediateUniRule annotation1
Active sitei346Proton acceptorUniRule annotation1
Active sitei376Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
Acetyl-CoA acyltransferaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadAUniRule annotation
Ordered Locus Names:ACICU_00321
OrganismiAcinetobacter baumannii (strain ACICU)
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001860191 – 3903-ketoacyl-CoA thiolaseAdd BLAST390

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2I2J8
SMRiB2I2J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012239
KOiK00632
OMAiCGGTESM

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
HAMAPiMF_01620 FadA, 1 hit
InterProiView protein in InterPro
IPR012805 FadA
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02445 fadA, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B2I2J8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLNPRDVV IVDGVRSAMG KSKNGMFRNV RADSLSAELV RALVARNQFD
60 70 80 90 100
VNEVEDLIWG CVNQTLEQGM NIGRNIGLLA GLPKTVAGQT VNRLCGSSMQ
110 120 130 140 150
AIHTAAAQIA TNQGDIFIIG GVEHMGHVGM MHGIDLNPEA SKHYAKASNM
160 170 180 190 200
MGLTAEMLGR MNGITREEQD AFGVESHRRA WAATQEGRFK NEIIGVEGHD
210 220 230 240 250
ANGFKILCDI DEVIRPDANL EAFKALKPVF DPKGGSVTAA TSSALSDGAS
260 270 280 290 300
AMLLMSAERA QALGLKPRAV IRSMAVAGCD AAIMGYGPVP ATQKALKRAG
310 320 330 340 350
LSIADIQTVE LNEAFAAQGL SVLKGLGLYD KQDIVNLNGG AIALGHPLGC
360 370 380 390
SGARITTTLL NVMEQQDTQI GLATMCIGLG QGIATVIERV
Length:390
Mass (Da):41,088
Last modified:June 10, 2008 - v1
Checksum:iB192B88AA9AF627A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA Translation: ACC55633.1
RefSeqiWP_000212712.1, NC_010611.1

Genome annotation databases

EnsemblBacteriaiACC55633; ACC55633; ACICU_00321
GeneIDi31350122
KEGGiabc:ACICU_00321

Similar proteinsi

Entry informationi

Entry nameiFADA_ACIBC
AccessioniPrimary (citable) accession number: B2I2J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 10, 2008
Last modified: February 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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