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Protein

Malate dehydrogenase

Gene

mdh

Organism
Acinetobacter baumannii (strain ACICU)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Binding sitei100SubstrateUniRule annotation1
Binding sitei107NADUniRule annotation1
Binding sitei114NADUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Active sitei189Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi131 – 133NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:ACICU_03222
OrganismiAcinetobacter baumannii (strain ACICU)
Taxonomic identifieri405416 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916051 – 328Malate dehydrogenaseAdd BLAST328

Structurei

3D structure databases

ProteinModelPortaliB2HZ52
SMRiB2HZ52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220953
KOiK00024
OMAiDPMTAFK

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit

Sequencei

Sequence statusi: Complete.

B2HZ52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQPVRVAVT GAAGQIGYSL LFRIASGEML GKDQPVILQL LEVPVEKAQQ
60 70 80 90 100
ALKGVMMELD DCAFPLLAGM IGTDDPKVAF KDADYALLVG SRPRGPGMER
110 120 130 140 150
ADLLKVNGEI FIGQGQALNE VASRDVKVLV VGNPANTNAY IAMKSAPDLP
160 170 180 190 200
AKNFTAMLRL DHNRALTQVA QKAGVAVADI EKLTVWGNHS PTMYADYRFA
210 220 230 240 250
TANGESLKDK INDPAWNKDV FLPTVGKRGA AIIEARGLSS AASAANAAID
260 270 280 290 300
HMRDWALGTN GKWVTMGVPS DGSYGIPEGV MFGFPVTTEN GEYKIVQGLE
310 320
IDEFSRERIN FTLNELEEER AAIADMVK
Length:328
Mass (Da):35,323
Last modified:June 10, 2008 - v1
Checksum:i4A3ABDD04F615F6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA Translation: ACC58534.1
RefSeqiWP_000813006.1, NC_010611.1

Genome annotation databases

EnsemblBacteriaiACC58534; ACC58534; ACICU_03222
KEGGiabc:ACICU_03222

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000863 Genomic DNA Translation: ACC58534.1
RefSeqiWP_000813006.1, NC_010611.1

3D structure databases

ProteinModelPortaliB2HZ52
SMRiB2HZ52
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACC58534; ACC58534; ACICU_03222
KEGGiabc:ACICU_03222

Phylogenomic databases

HOGENOMiHOG000220953
KOiK00024
OMAiDPMTAFK

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_ACIBC
AccessioniPrimary (citable) accession number: B2HZ52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 10, 2008
Last modified: November 7, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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