Cbr3

Functionⁱ

GO - Molecular functionⁱ

3-keto sterol reductase activity
Source: RGD
Inferred from direct assayⁱ
- 18983987
carbonyl reductase (NADPH) activity
Source: RGD
Inferred from direct assayⁱ
- 18983987
NADPH binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cognition Source: Ensembl
phylloquinone catabolic process
Source: RGD
Inferred from direct assayⁱ
- 18983987

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

BRENDAⁱ	1.1.1.184 5301
Reactomeⁱ	R-RNO-211945 Phase I - Functionalization of compounds

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Carbonyl reductase 3Imported Submitted name: Carbonyl reductase 3 (Predicted)Imported
Gene namesⁱ	Name:Cbr3Imported Synonyms:Cbr3_predictedImported ORF Names:rCG_53069Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	1309728 Cbr3

RGDⁱ

1309728 Cbr3

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000001701 Expressed in 9 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000001701 Expressed in 9 organ(s), highest expression level in colon

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002310

STRINGⁱ

10116.ENSRNOP00000002310

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1208 Eukaryota COG1028 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046499
HOVERGENⁱ	HBG001909
KEGG Orthology (KO) More...KOⁱ	K00084
OMAⁱ	NEMDTNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0V7L
TreeFamⁱ	TF329359

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B2GV72-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSCSRVALV TGANKGIGFA ITRDLCRKFS GDVVLTARDE ARGRAAVKQL 
        60         70         80         90        100
QAEGLSPRFH QLDIDNPQSI RALRDFLRKE YGGLNVLVNN AGIAFRMDDP 
       110        120        130        140        150
TPFDVQAEVT LKTNFFATRN VCTELLPIMK PHGRVVNVSS LQGLKALENC 
       160        170        180        190        200
SEDLQERFRC DTLTEGDLVD LMKKFVEDTK NEVHEREGWP DSAYGVSKLG 
       210        220        230        240        250
VTVLTRILAR QLDEKRKADR ILLNACCPGW VKTDMARDQG SRTVEEGAET 
       260        270 
PVYLALLPPD ATEPHGQLVR DKVVQTW

Length:277

Mass (Da):30,841

Last modified:June 10, 2008 - v1

Checksum:ⁱ05DBA2BCCD985EB0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07033657 Genomic DNA No translation available. BC166553 mRNA Translation: AAI66553.1 CH474083 Genomic DNA Translation: EDL76737.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001100580.1, NM_001107110.1
UniGeneⁱ	Rn.8624

Genome annotation databases

Ensemblⁱ	ENSRNOT00000002310; ENSRNOP00000002310; ENSRNOG00000001701
GeneIDⁱ	304078
KEGGⁱ	rno:304078
UCSC genome browser More...UCSCⁱ	RGD:1309728 rat

Protein	Similar proteins		Species	Score	Length	Source
B2GV72	Carbonyl reductase [NADPH] 3		MOUSE		277	UniRef90_Q8K354
carbonyl reductase [NADPH] 3 isoform X2		DIPOR		321
Carbonyl reductase [NADPH] 3		TUPCH		277
LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 3		TARSY		277
Uncharacterized protein		ICTTR		277
+7

Protein	Similar proteins		Species	Score	Length	Source
B2GV72	Carbonyl reductase [NADPH] 1		RAT		277	UniRef50_P47727
Carbonyl reductase [NADPH] 3		MOUSE		277
20-beta-hydroxysteroid dehydrogenase		ORYLA		275
Carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase		ORENI		280
Carbonyl reductase [NADPH] 1		LARCR		334
+111

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07033657 Genomic DNA No translation available. BC166553 mRNA Translation: AAI66553.1 CH474083 Genomic DNA Translation: EDL76737.1
RefSeqⁱ	NP_001100580.1, NM_001107110.1
UniGeneⁱ	Rn.8624

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000002310

STRINGⁱ

10116.ENSRNOP00000002310

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000002310; ENSRNOP00000002310; ENSRNOG00000001701
GeneIDⁱ	304078
KEGGⁱ	rno:304078
UCSCⁱ	RGD:1309728 rat

Organism-specific databases

CTDⁱ	874
RGDⁱ	1309728 Cbr3

Phylogenomic databases

eggNOGⁱ	KOG1208 Eukaryota COG1028 LUCA
GeneTreeⁱ	ENSGT00510000046499
HOVERGENⁱ	HBG001909
KOⁱ	K00084
OMAⁱ	NEMDTNS
OrthoDBⁱ	EOG091G0V7L
TreeFamⁱ	TF329359

Enzyme and pathway databases

BRENDAⁱ	1.1.1.184 5301
Reactomeⁱ	R-RNO-211945 Phase I - Functionalization of compounds

Gene expression databases

Bgeeⁱ	ENSRNOG00000001701 Expressed in 9 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000001701 Expressed in 9 organ(s), highest expression level in colon

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2GV72_RAT
Accessionⁱ	B2GV72Primary (citable) accession number: B2GV72
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	October 10, 2018
	This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2GV72 (B2GV72_RAT)

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Carbonyl reductase 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ