UniProtKB - B2GV68 (B2GV68_RAT)
Protein
Submitted name:
AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Gene
Alkbh2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Cofactori
Fe2+ARBA annotation
GO - Molecular functioni
- 2-oxoglutarate-dependent dioxygenase activity Source: RGD
- cytosine C-5 DNA demethylase activity Source: RGD
- DNA-N1-methyladenine dioxygenase activity Source: RGD
- ferrous iron binding Source: RGD
GO - Biological processi
- DNA dealkylation involved in DNA repair Source: RGD
- nucleic acid phosphodiester bond hydrolysis Source: GOC
- oxidative DNA demethylation Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: AlkB homolog 2, alpha-ketoglutarate-dependent dioxygenaseImportedSubmitted name: Alkbh2 proteinImported |
Gene namesi | Name:Alkbh2Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306377, Alkbh2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000028584, Expressed in liver and 21 other tissues |
ExpressionAtlasi | B2GV68, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 235 | Fe2OG dioxygenaseInterPro annotationAdd BLAST | 106 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Phylogenomic databases
eggNOGi | ENOG502QTDK, Eukaryota |
GeneTreei | ENSGT00940000159009 |
TreeFami | TF331732 |
Family and domain databases
Gene3Di | 2.60.120.590, 1 hit |
InterProi | View protein in InterPro IPR027450, AlkB-like IPR037151, AlkB-like_sf IPR032852, ALKBH2 IPR005123, Oxoglu/Fe-dep_dioxygenase |
PANTHERi | PTHR31573, PTHR31573, 1 hit |
Pfami | View protein in Pfam PF13532, 2OG-FeII_Oxy_2, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B2GV68-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRFLVRPDR GDIQGAAEEP APTGEASGDM QSPGWQHFRA EGLNCDYTVL
60 70 80 90 100
FRKAEADQIF RELEQEVEYF TGALAKVQVF GKWHSVPRKQ ATYGDAGLTY
110 120 130 140 150
TFSGLTLTPK PWIPVLERVR DQVCRVTGQT FNFVLVNRYK DGCDHIGEHR
160 170 180 190 200
DDERELAPGS PIASVSFGAC RDILFRHKDS RGKRPRRAVE VVRLQLAHGS
210 220 230
LLMMNHPTNT HWYHSLPIRK RVLAPRINLT FRKILPTKK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K5G5 | A0A0G2K5G5_RAT | AlkB homolog 2, alpha-ketoglutarate... | Alkbh2 | 287 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC131519 Genomic DNA No translation available. BC166547 mRNA Translation: AAI66547.1 |
RefSeqi | NP_001119745.1, NM_001126273.1 |
Genome annotation databases
Ensembli | ENSRNOT00000031658; ENSRNOP00000030705; ENSRNOG00000028584 |
GeneIDi | 304578 |
KEGGi | rno:304578 |
UCSCi | RGD:1306377, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC131519 Genomic DNA No translation available. BC166547 mRNA Translation: AAI66547.1 |
RefSeqi | NP_001119745.1, NM_001126273.1 |
3D structure databases
SMRi | B2GV68 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000030705 |
Proteomic databases
PRIDEi | B2GV68 |
Genome annotation databases
Ensembli | ENSRNOT00000031658; ENSRNOP00000030705; ENSRNOG00000028584 |
GeneIDi | 304578 |
KEGGi | rno:304578 |
UCSCi | RGD:1306377, rat |
Organism-specific databases
CTDi | 121642 |
RGDi | 1306377, Alkbh2 |
Phylogenomic databases
eggNOGi | ENOG502QTDK, Eukaryota |
GeneTreei | ENSGT00940000159009 |
TreeFami | TF331732 |
Gene expression databases
Bgeei | ENSRNOG00000028584, Expressed in liver and 21 other tissues |
ExpressionAtlasi | B2GV68, baseline and differential |
Family and domain databases
Gene3Di | 2.60.120.590, 1 hit |
InterProi | View protein in InterPro IPR027450, AlkB-like IPR037151, AlkB-like_sf IPR032852, ALKBH2 IPR005123, Oxoglu/Fe-dep_dioxygenase |
PANTHERi | PTHR31573, PTHR31573, 1 hit |
Pfami | View protein in Pfam PF13532, 2OG-FeII_Oxy_2, 1 hit |
PROSITEi | View protein in PROSITE PS51471, FE2OG_OXY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2GV68_RAT | |
Accessioni | B2GV68Primary (citable) accession number: B2GV68 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | February 10, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |