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UniProtKB - B2GV01 (B2GV01_RAT)
Protein
Submitted name:
Metastasis-associated 1 family, member 2
Gene
Mta2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: InterPro
- DNA-binding transcription factor binding Source: ARUK-UCL
- histone deacetylase activity Source: RGD
- histone deacetylase binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
- sequence-specific DNA binding Source: InterPro
- transcription coactivator activity Source: GO_Central
- transcription coregulator activity Source: RGD
- transcription corepressor activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- chromatin remodeling Source: Ensembl
- DNA methylation Source: RGD
- histone deacetylation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of fibroblast migration Source: RGD
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-3214815, HDACs deacetylate histones R-RNO-6804758, Regulation of TP53 Activity through Acetylation R-RNO-73762, RNA Polymerase I Transcription Initiation R-RNO-8943724, Regulation of PTEN gene transcription |
Names & Taxonomyi
Protein namesi | Submitted name: Metastasis-associated 1 family, member 2ImportedSubmitted name: Metastasis-associated gene family, member 2ImportedSubmitted name: Mta2 proteinImported |
Gene namesi | Name:Mta2Imported ORF Names:rCG_47212Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306743, Mta2 |
Subcellular locationi
Nucleus
- histone deacetylase complex Source: RGD
- nucleoplasm Source: GO_Central
- nucleus Source: RGD
- NuRD complex Source: RGD
Other locations
- chromosome, telomeric region Source: Ensembl
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000019913, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: ARUK-UCL
- histone deacetylase binding Source: RGD
- RNA polymerase II-specific DNA-binding transcription factor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027141 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 144 | BAHInterPro annotationAdd BLAST | 141 | |
Domaini | 145 – 256 | ELM2InterPro annotationAdd BLAST | 112 | |
Domaini | 263 – 315 | SANTInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 412 – 437 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 580 – 599 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 647 – 668 | DisorderedSequence analysisAdd BLAST | 22 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
HOGENOMi | CLU_006585_2_0_1 |
OMAi | KPPLMAV |
OrthoDBi | 802091at2759 |
TreeFami | TF106444 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR037964, MTA2 IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit PTHR10865:SF4, PTHR10865:SF4, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
i Sequence
Sequence statusi: Complete.
B2GV01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD
60 70 80 90 100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT
110 120 130 140 150
HIRGKCSVTL LNETDILNQY LEKEDCFFYS LVFDPVQKTL LADQGEIRVG
160 170 180 190 200
CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV
210 220 230 240 250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS
260 270 280 290 300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL
310 320 330 340 350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV
360 370 380 390 400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK
410 420 430 440 450
YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN
460 470 480 490 500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP
510 520 530 540 550
KAAKTPLKIH PLARLPLAAI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN
560 570 580 590 600
RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD
610 620 630 640 650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKT ALMTVRPPVP
660
LPASSHPAST NEPIVLED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108988 Genomic DNA No translation available. BC166471 mRNA Translation: AAI66471.1 CH473953 Genomic DNA Translation: EDM12761.1 |
RefSeqi | NP_001094210.1, NM_001100740.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027141; ENSRNOP00000027141; ENSRNOG00000019913 |
GeneIDi | 361724 |
KEGGi | rno:361724 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC108988 Genomic DNA No translation available. BC166471 mRNA Translation: AAI66471.1 CH473953 Genomic DNA Translation: EDM12761.1 |
RefSeqi | NP_001094210.1, NM_001100740.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027141 |
Genome annotation databases
Ensembli | ENSRNOT00000027141; ENSRNOP00000027141; ENSRNOG00000019913 |
GeneIDi | 361724 |
KEGGi | rno:361724 |
Organism-specific databases
CTDi | 9219 |
RGDi | 1306743, Mta2 |
Phylogenomic databases
eggNOGi | KOG3554, Eukaryota |
GeneTreei | ENSGT01030000234573 |
HOGENOMi | CLU_006585_2_0_1 |
OMAi | KPPLMAV |
OrthoDBi | 802091at2759 |
TreeFami | TF106444 |
Enzyme and pathway databases
Reactomei | R-RNO-3214815, HDACs deacetylate histones R-RNO-6804758, Regulation of TP53 Activity through Acetylation R-RNO-73762, RNA Polymerase I Transcription Initiation R-RNO-8943724, Regulation of PTEN gene transcription |
Gene expression databases
Bgeei | ENSRNOG00000019913, Expressed in thymus and 21 other tissues |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR040138, MIER/MTA IPR035170, MTA1_R1 IPR037964, MTA2 IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
PANTHERi | PTHR10865, PTHR10865, 1 hit PTHR10865:SF4, PTHR10865:SF4, 1 hit |
Pfami | View protein in Pfam PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit PF17226, MTA_R1, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2GV01_RAT | |
Accessioni | B2GV01Primary (citable) accession number: B2GV01 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | January 19, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |