Mta2

Functionⁱ

GO - Molecular functionⁱ

chromatin binding Source: InterPro
histone deacetylase activity Source: Ensembl
histone deacetylase binding
Source: RGD
Inferred from physical interactionⁱ
- 18413351
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA methylation Source: Ensembl
histone deacetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of fibroblast migration
Source: RGD
Inferred from direct assayⁱ
- 24468085

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-6804758 Regulation of TP53 Activity through Acetylation R-RNO-73762 RNA Polymerase I Transcription Initiation R-RNO-8943724 Regulation of PTEN gene transcription

Reactomeⁱ

R-RNO-6804758 Regulation of TP53 Activity through Acetylation
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-8943724 Regulation of PTEN gene transcription

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Metastasis-associated 1 family, member 2Imported Submitted name: Metastasis-associated gene family, member 2Imported Submitted name: Mta2 proteinImported
Gene namesⁱ	Name:Mta2Imported ORF Names:rCG_47212Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	1306743 Mta2

RGDⁱ

1306743 Mta2

Keywords - Cellular componentⁱ

NucleusSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000019913 Expressed in 10 organ(s), highest expression level in spleen

Bgeeⁱ

ENSRNOG00000019913 Expressed in 10 organ(s), highest expression level in spleen

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000027141

STRINGⁱ

10116.ENSRNOP00000027141

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 144	BAHInterPro annotationAdd BLAST	141
Domainⁱ	145 – 256	ELM2InterPro annotationAdd BLAST	112
Domainⁱ	263 – 315	SANTInterPro annotationAdd BLAST	53

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
KEGG Orthology (KO) More...KOⁱ	K11660
OMAⁱ	GPPTPIN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04Z4
TreeFamⁱ	TF106444

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR037964 MTA2 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
PANTHERⁱ	PTHR10865:SF4 PTHR10865:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B2GV01-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD 
        60         70         80         90        100
ISSSLNSLAD SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT 
       110        120        130        140        150
HIRGKCSVTL LNETDILNQY LEKEDCFFYS LVFDPVQKTL LADQGEIRVG 
       160        170        180        190        200
CKFQAEIPDR LAEGESDNRN QQKMEMKVWD PDNPLTDRQI DQFLVVARAV 
       210        220        230        240        250
GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR NGYDLAKAMS 
       260        270        280        290        300
TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL 
       310        320        330        340        350
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV 
       360        370        380        390        400
GSKPGMNGAG FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK 
       410        420        430        440        450
YGGLKTPTQL EGAARGTTEP HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN 
       460        470        480        490        500
RQTFLLQTTK LTRLARRMCR DLLQPRRAAR RPYAPINANA IKAECSIRLP 
       510        520        530        540        550
KAAKTPLKIH PLARLPLAAI VKDLVAQAPL KPKTPRGTKT PINRNQLTQN 
       560        570        580        590        600
RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD 
       610        620        630        640        650
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKT ALMTVRPPVP 
       660 
LPASSHPAST NEPIVLED

Length:668

Mass (Da):74,960

Last modified:June 10, 2008 - v1

Checksum:ⁱ89C28FDBF1D331E8

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC108988 Genomic DNA No translation available. BC166471 mRNA Translation: AAI66471.1 CH473953 Genomic DNA Translation: EDM12761.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001094210.1, NM_001100740.1
UniGeneⁱ	Rn.137719

Genome annotation databases

Ensemblⁱ	ENSRNOT00000027141; ENSRNOP00000027141; ENSRNOG00000019913
GeneIDⁱ	361724
KEGGⁱ	rno:361724

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B2GV01	Mta2 protein (Fragment)		RAT		236	UniRef100_B2GV01

Protein	Similar proteins		Species	Score	Length	Source
B2GV01	Metastasis-associated protein MTA2		HUMAN		668	UniRef90_O94776
Metastasis-associated protein MTA2		MOUSE		668
MTA2 isoform 1		PANTR		668
Uncharacterized protein		PANPA		668
Metastasis-associated MTA1-like protein (Fragment)		Daphnia magna		161
+129

Protein	Similar proteins		Species	Score	Length	Source
B2GV01	Metastasis-associated protein MTA2		HUMAN		668	UniRef50_O94776
Metastasis-associated protein MTA2		MOUSE		668
Metastasis-associated protein MTA3		BOVIN		590
MTA2 isoform 1		PANTR		668
Uncharacterized protein		PANPA		668
+685

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC108988 Genomic DNA No translation available. BC166471 mRNA Translation: AAI66471.1 CH473953 Genomic DNA Translation: EDM12761.1
RefSeqⁱ	NP_001094210.1, NM_001100740.1
UniGeneⁱ	Rn.137719

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000027141

STRINGⁱ

10116.ENSRNOP00000027141

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000027141; ENSRNOP00000027141; ENSRNOG00000019913
GeneIDⁱ	361724
KEGGⁱ	rno:361724

Organism-specific databases

CTDⁱ	9219
RGDⁱ	1306743 Mta2

Phylogenomic databases

eggNOGⁱ	KOG3554 Eukaryota ENOG410XSAJ LUCA
GeneTreeⁱ	ENSGT00580000081398
HOGENOMⁱ	HOG000045387
HOVERGENⁱ	HBG002598
KOⁱ	K11660
OMAⁱ	GPPTPIN
OrthoDBⁱ	EOG091G04Z4
TreeFamⁱ	TF106444

Enzyme and pathway databases

Reactomeⁱ	R-RNO-6804758 Regulation of TP53 Activity through Acetylation R-RNO-73762 RNA Polymerase I Transcription Initiation R-RNO-8943724 Regulation of PTEN gene transcription

Reactomeⁱ

R-RNO-6804758 Regulation of TP53 Activity through Acetylation
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-8943724 Regulation of PTEN gene transcription

Gene expression databases

Bgeeⁱ	ENSRNOG00000019913 Expressed in 10 organ(s), highest expression level in spleen

Bgeeⁱ

ENSRNOG00000019913 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 1 hit
InterProⁱ	View protein in InterPro IPR001025 BAH_dom IPR000949 ELM2_dom IPR009057 Homeobox-like_sf IPR035170 MTA1_R1 IPR037964 MTA2 IPR001005 SANT/Myb IPR017884 SANT_dom IPR000679 Znf_GATA
PANTHERⁱ	PTHR10865:SF4 PTHR10865:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF01426 BAH, 1 hit PF01448 ELM2, 1 hit PF00320 GATA, 1 hit PF17226 MTA_R1, 1 hit
SMARTⁱ	View protein in SMART SM00439 BAH, 1 hit SM01189 ELM2, 1 hit SM00717 SANT, 1 hit SM00401 ZnF_GATA, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS51038 BAH, 1 hit PS51156 ELM2, 1 hit PS51293 SANT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2GV01_RAT
Accessionⁱ	B2GV01Primary (citable) accession number: B2GV01
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 10, 2008
	Last sequence update:	June 10, 2008
	Last modified:	November 7, 2018
	This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2GV01 (B2GV01_RAT)

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Metastasis-associated 1 family, member 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ