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UniProtKB - B2GUY2 (TFR2_RAT)
Protein
Transferrin receptor protein 2
Gene
Tfr2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation (By similarity).
By similarityGO - Molecular functioni
- co-receptor binding Source: RGD
- metalloexopeptidase activity Source: InterPro
- transferrin receptor activity Source: RGD
GO - Biological processi
- acute-phase response Source: RGD
- cellular response to iron ion Source: RGD
- endocytic iron import into cell Source: RGD
- iron ion homeostasis Source: RGD
- positive regulation of endocytosis Source: RGD
- positive regulation of peptide hormone secretion Source: RGD
- positive regulation of protein maturation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- receptor-mediated endocytosis Source: RGD
- response to iron ion Source: RGD
- transferrin transport Source: RGD
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-RNO-917977, Transferrin endocytosis and recycling |
Protein family/group databases
MEROPSi | M28.973 |
Names & Taxonomyi
Protein namesi | Recommended name: Transferrin receptor protein 2Short name: TfR2 |
Gene namesi | Name:Tfr2 Synonyms:Trfr2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310152, Tfr2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type II membrane protein By similarity
Plasma Membrane
- external side of plasma membrane Source: RGD
- HFE-transferrin receptor complex Source: RGD
- integral component of plasma membrane Source: RGD
Other locations
- cytoplasmic vesicle Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 81 | CytoplasmicSequence analysisAdd BLAST | 81 | |
Transmembranei | 82 – 102 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 798 | ExtracellularSequence analysisAdd BLAST | 696 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000348233 | 1 – 798 | Transferrin receptor protein 2Add BLAST | 798 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 106 | InterchainSequence analysis | ||
Disulfide bondi | 109 | InterchainSequence analysis | ||
Glycosylationi | 235 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 334 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 535 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | B2GUY2 |
PeptideAtlasi | B2GUY2 |
PRIDEi | B2GUY2 |
PTM databases
GlyGeni | B2GUY2, 3 sites |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000001407, Expressed in liver and 21 other tissues |
Genevisiblei | B2GUY2, RN |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- co-receptor binding Source: RGD
Protein-protein interaction databases
IntActi | B2GUY2, 1 interactor |
STRINGi | 10116.ENSRNOP00000001905 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 45 | DisorderedSequence analysisAdd BLAST | 21 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 23 – 26 | Endocytosis signalSequence analysis | 4 |
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2195, Eukaryota |
GeneTreei | ENSGT01030000234598 |
HOGENOMi | CLU_005688_5_0_1 |
InParanoidi | B2GUY2 |
OMAi | FSQGPHK |
OrthoDBi | 804230at2759 |
PhylomeDBi | B2GUY2 |
TreeFami | TF312981 |
Family and domain databases
CDDi | cd02128, PA_TfR, 1 hit |
Gene3Di | 1.20.930.40, 1 hit |
InterProi | View protein in InterPro IPR003137, PA_domain IPR007484, Peptidase_M28 IPR039373, Peptidase_M28B IPR036757, TFR-like_dimer_dom_sf IPR037324, TfR1/2_PA |
PANTHERi | PTHR10404, PTHR10404, 1 hit |
Pfami | View protein in Pfam PF02225, PA, 1 hit PF04389, Peptidase_M28, 1 hit |
SUPFAMi | SSF47672, SSF47672, 1 hit |
i Sequence
Sequence statusi: Complete.
B2GUY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQRWGLLRK VQQWSPRPSQ TIYRRVEGPQ LENLEEEDRE EGEELPAQFC
60 70 80 90 100
PMELKGPERL GSCPGRSIPI PWAAAGRKAA PYLVLTTLLI FTGAFLLGYV
110 120 130 140 150
AFRGSCQACG DSVLVVGEDV NSEDSSRGTL YWSDLQDMFL RFLGEGRMED
160 170 180 190 200
TIRLTSLRER VAGSARMATL VQDILDKLSR QKLDHVWTDT HYVGLQFPDP
210 220 230 240 250
AHPNTLHWVG ADGSVQEQLP LEDPEVYCPY SATGNATGKL VYAHYGRRED
260 270 280 290 300
LQDLKAKDVE LAGSLLLVRA GITSFAQKVA IAQDFGAHGV LIYPDPADFS
310 320 330 340 350
QDPHKPGLSS DRAVYGHVHL GTGDPYTPGF PSFNQTQFPP VESSGLPNIP
360 370 380 390 400
AQPISADVAD RLLRKLTGPV APQEWKGRLS DSPYRLGPGP GLRLVVNNHR
410 420 430 440 450
TSTPISNIFA CIEGFAEPDH YVVIGAQRDA WGPGAAKSAV GTAILLELVR
460 470 480 490 500
TFSSMVSSGF RPRRSLLFIS WDGGDFGSVG ATEWLEGYLS VLHLKAVVYV
510 520 530 540 550
SLDNSVLGDG KFHAKTSPLL VSLIENILKQ VDSPNHSGQT LYDQVAFTHP
560 570 580 590 600
SWDAEVIQPL PMDSSAYSFT AFAGVPAVEF SFMEDDRVYP FLHTKEDTYE
610 620 630 640 650
NLHKMLRGRL PAVVLAVAQL AGQLLIRLSH DHLLPLDFGR YGDVVLRHIG
660 670 680 690 700
NLNEFSGDLK ARGLTLQWVY SARGDYIRAA EKLRKEIYSS EQSDERLMRM
710 720 730 740 750
YNVRIMRVEF YFLSQYVSPA DSPFRHIFLG QGDHTLGALV EHLRMLRSDG
760 770 780 790
SGAASSGLSP GLGFQESRFR RQLALLTWTL QGAANALSGD VWNIDNNF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473973 Genomic DNA Translation: EDM13257.1 CH473973 Genomic DNA Translation: EDM13258.1 CH473973 Genomic DNA Translation: EDM13259.1 BC166451 mRNA Translation: AAI66451.1 |
RefSeqi | NP_001099386.1, NM_001105916.1 XP_006249179.1, XM_006249117.2 XP_006249180.1, XM_006249118.1 XP_008767347.1, XM_008769125.2 XP_008767348.1, XM_008769126.1 |
Genome annotation databases
Ensembli | ENSRNOT00000001905; ENSRNOP00000001905; ENSRNOG00000001407 ENSRNOT00000082895; ENSRNOP00000072585; ENSRNOG00000001407 |
GeneIDi | 288562 |
KEGGi | rno:288562 |
UCSCi | RGD:1310152, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473973 Genomic DNA Translation: EDM13257.1 CH473973 Genomic DNA Translation: EDM13258.1 CH473973 Genomic DNA Translation: EDM13259.1 BC166451 mRNA Translation: AAI66451.1 |
RefSeqi | NP_001099386.1, NM_001105916.1 XP_006249179.1, XM_006249117.2 XP_006249180.1, XM_006249118.1 XP_008767347.1, XM_008769125.2 XP_008767348.1, XM_008769126.1 |
3D structure databases
SMRi | B2GUY2 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | B2GUY2, 1 interactor |
STRINGi | 10116.ENSRNOP00000001905 |
Protein family/group databases
MEROPSi | M28.973 |
PTM databases
GlyGeni | B2GUY2, 3 sites |
Proteomic databases
PaxDbi | B2GUY2 |
PeptideAtlasi | B2GUY2 |
PRIDEi | B2GUY2 |
Genome annotation databases
Ensembli | ENSRNOT00000001905; ENSRNOP00000001905; ENSRNOG00000001407 ENSRNOT00000082895; ENSRNOP00000072585; ENSRNOG00000001407 |
GeneIDi | 288562 |
KEGGi | rno:288562 |
UCSCi | RGD:1310152, rat |
Organism-specific databases
CTDi | 7036 |
RGDi | 1310152, Tfr2 |
Phylogenomic databases
eggNOGi | KOG2195, Eukaryota |
GeneTreei | ENSGT01030000234598 |
HOGENOMi | CLU_005688_5_0_1 |
InParanoidi | B2GUY2 |
OMAi | FSQGPHK |
OrthoDBi | 804230at2759 |
PhylomeDBi | B2GUY2 |
TreeFami | TF312981 |
Enzyme and pathway databases
Reactomei | R-RNO-917977, Transferrin endocytosis and recycling |
Miscellaneous databases
PROi | PR:B2GUY2 |
Gene expression databases
Bgeei | ENSRNOG00000001407, Expressed in liver and 21 other tissues |
Genevisiblei | B2GUY2, RN |
Family and domain databases
CDDi | cd02128, PA_TfR, 1 hit |
Gene3Di | 1.20.930.40, 1 hit |
InterProi | View protein in InterPro IPR003137, PA_domain IPR007484, Peptidase_M28 IPR039373, Peptidase_M28B IPR036757, TFR-like_dimer_dom_sf IPR037324, TfR1/2_PA |
PANTHERi | PTHR10404, PTHR10404, 1 hit |
Pfami | View protein in Pfam PF02225, PA, 1 hit PF04389, Peptidase_M28, 1 hit |
SUPFAMi | SSF47672, SSF47672, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TFR2_RAT | |
Accessioni | B2GUY2Primary (citable) accession number: B2GUY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | February 23, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families