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Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

abcb8

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi477 – 484ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial
Gene namesi
Name:abcb8
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1010256 abcb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei58 – 78HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei115 – 135HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei168 – 188HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei268 – 288HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei342 – 362HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000356237? – 688ATP-binding cassette sub-family B member 8, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiB2GUP8
PRIDEiB2GUP8

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi8364.ENSXETP00000026160

Structurei

3D structure databases

ProteinModelPortaliB2GUP8
SMRiB2GUP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 409ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST290
Domaini442 – 679ABC transporterPROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
HOVERGENiHBG008358
InParanoidiB2GUP8
KOiK05655

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2GUP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFHFLQAGL RQCRPPARLV GLETGLSGAR GPSLPATLAN YSRLRNACRP
60 70 80 90 100
PWRSPWKPVK KGKLLAVLLG PAVLGVGVRA ARCQVELIAP PLIVPQGARP
110 120 130 140 150
EPEFNWAEFW KLLRPQLIAL LTAVLLAFGA ALLNIRIPLM LGELVNVVSR
160 170 180 190 200
YTREHAGNYL QEVQGPALKL LCLYGAQGLL TCGYIVLLSR VGERVAGSMR
210 220 230 240 250
KSLFFSLLRQ DVAFFDAEKT GLLVNRLTSD VQEFKSSFKQ VISQGLRSLT
260 270 280 290 300
QTVGCFLSLY YISPKLTGLL LVVMPVLVGS GALIGSFLRK LSRRAQEQVA
310 320 330 340 350
RATGLADEAL GNVRTVKAFA MESREMELYS AEVDKSSGQN EVLGVGIAVF
360 370 380 390 400
QGLSNVVLNC IVLGTIFAGG SLMSSKELSA GELMSFLVAS QTVQRSMANM
410 420 430 440 450
SVLFGQVVRG LSAGGRVFEF MSLEPTIPLS GGFKLPVLRG EIHFKDVSFS
460 470 480 490 500
YPTRPGHEVL RSFDLRIPHG KTVALVGQSG GGKSTVAALL ERFYDPTEGA
510 520 530 540 550
VQLDGVDIRI LDPSWLRGEV IGFINQEPVL FGTTIIENIR FGRPDATDAE
560 570 580 590 600
VHEAAIQANA DSFIRSFPEG YNTMLGERGV TLSGGQKQRV AIARALLKDP
610 620 630 640 650
KILILDEATS ALDTESERAV QVALDRARSG RTVLVIAHRL STISEADFIV
660 670 680
VLSKGQVAEF GTHQDLLRRG GLYADLIRRQ NQESQEAQ
Length:688
Mass (Da):74,747
Last modified:June 10, 2008 - v1
Checksum:iC013E76EAB7E93C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166360 mRNA Translation: AAI66360.1
RefSeqiNP_001121515.1, NM_001128043.1
UniGeneiStr.55614

Genome annotation databases

GeneIDi100158634
KEGGixtr:100158634

Similar proteinsi

Entry informationi

Entry nameiABCB8_XENTR
AccessioniPrimary (citable) accession number: B2GUP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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