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Protein

Serine/threonine-protein kinase

Gene

prkd1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Activity regulationi

Activated by DAG and phorbol esters.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei565ATPUniRule annotation1
Active sitei659Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi542 – 550ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinaseUniRule annotation (EC:2.7.11.13UniRule annotation)
Gene namesi
Name:prkd1Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-487626 prkd1

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2GU99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 162Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini236 – 286Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini377 – 496PHInterPro annotationAdd BLAST120
Domaini536 – 792Protein kinaseInterPro annotationAdd BLAST257

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.UniRule annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG4236 Eukaryota
ENOG410XQZ3 LUCA
HOGENOMiHOG000015135
HOVERGENiHBG003564
KOiK06070
OrthoDBiEOG091G02RG

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015727 Protein_Kinase_C_mu-related
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22968 PTHR22968, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000552 PKC_mu_nu_D2, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00233 PH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B2GU99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPPVIRPP SPAGTGLSLQ IQIGLSREPV LLPEPGELSL GAVREMACSI
60 70 80 90 100
VDQKFPECGF YGMYDKILLF RHDPNSENIL QLVKSEADIQ EGDLIEVVLS
110 120 130 140 150
ASATFEDFQI RPHALFVHSY RAPAFCDHCG EMLWGLVRQG LKCEGCGLNY
160 170 180 190 200
HKRCAFKIPN NCSGVRKRRL SNVSLTGLSS IRTLSVEPLS SAPDEPLLQK
210 220 230 240 250
SPSESFLGRH SRSGSQLHIG RPIKLDKFFL TKVKVPHTFV IHSYTRPTVC
260 270 280 290 300
QHCKKLLKGL FRQGLQCKDC KFNCHKRCAS RVPHNCLGED AINGDLSDVM
310 320 330 340 350
MEEGSDDNES RPEDMDESPT TDSEGSISGC RSENGEMQEP DQDQDASDRT
360 370 380 390 400
ISPSASNNIP LMRVVQSVKH TKRKSSSVMK EGWMVHYTSK DPMRKRHYWR
410 420 430 440 450
LDSKCITLFQ NDTGSKYYKE IPLSEILSLE PAKDLSLLCP GANPHCFEIT
460 470 480 490 500
TANVVYYVGE NLPQPVPPDM GNVMLTSGAG LDIARMWEIA IQHALMPVNP
510 520 530 540 550
KGANDGSTQH RDVSISISVS NCQVHENVDI SSVYQIFPDE VLGSGQFGIV
560 570 580 590 600
YGGKHRKTGR DVAIKIIDKL RFPTKQESQL RNEVAILQNL HHQGVVNLEC
610 620 630 640 650
MFETPERVFV VMEKLHGDML EMILSSEKGR LPERITKFLV TQILVALRHL
660 670 680 690 700
HFKNIVHCDL KPENVLLASA DPFPQVKLCD FGFARIIGEK SFRRSVVGTP
710 720 730 740 750
AYLAPEVLRN RGYNRSLDMW SVGVIIYVSL SGTFPFNEDE DIHDQIQNAA
760 770 780 790 800
FMYPPNPWKE ISPDAIDLIN NLLQVKMRKR YSVDKTLNHP WLQDYQTWLD
810 820 830 840 850
LRELECKIGE RYITHESDDP RWQQYSEDCR LLYPPHLLPP PSYEPEDAEM
860
RALEERVSIL
Length:860
Mass (Da):97,118
Last modified:June 10, 2008 - v1
Checksum:i523BF2D9A2D7A9A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC166194 mRNA Translation: AAI66194.1
RefSeqiNP_001120884.1, NM_001127412.1
UniGeneiStr.67407

Genome annotation databases

GeneIDi100151704
KEGGixtr:100151704

Similar proteinsi

Entry informationi

Entry nameiB2GU99_XENTR
AccessioniPrimary (citable) accession number: B2GU99
Entry historyiIntegrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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