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Entry version 26 (17 Jun 2020)
Sequence version 1 (10 Jun 2008)
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Protein

Mite allergen Der f 21.0101

Gene
N/A
Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mite allergen Der f 21.0101Curated
Alternative name(s):
Allergen Der f 211 PublicationImported
Mite group 21 allergen Der f 213 Publications
Allergen: Der f 21.0101Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDermatophagoides farinae (American house dust mite)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6954 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human (PubMed:27069539, PubMed:30894561). Binds to IgE in 29% of the 38 dust mite allergic children tested. 43% of the 98 dust mite allergic adults tested show a positive response to this protein by skin prick test (PubMed:27069539). Binds to IgE in all of the 24 D.farinae allergic patients tested. There is a positive correlation between the number of specific major epitope residues in this allergen and the specific IgE level of the atopic population. The higher the IgE level of the patient for this protein, the higher the number of recognized epitope residues in this allergen by the IgE of the individual out of the 38 determined surface-exposed epitopes tested (PubMed:30894561). Causes an allergic reaction in mice. Mice allergic to this protein display elevated specific IgE and IgG1, increased levels of interferon gamma and interleukin-4 as well as increased proliferation of the spleen cells, airway hyperresponsiveness, large quantity of exudates in the airway lumen and profound inflammatory cell infiltration in the lung tissue (PubMed:27069539).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi26D → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi27K → A: Decreased IgE-binding by more than half of the 24 patients tested. Identified as a major epitope. 1 Publication1
Mutagenesisi34H → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi38E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi39E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi41E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi42E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi43K → A: Decreased IgE-binding by more than half of the 24 patients tested. Identified as a major epitope. 1 Publication1
Mutagenesisi45D → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi48E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi49H → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi56E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi59K → A: Decreased IgE-binding by more than half of the 24 patients tested. Identified as a major epitope. 1 Publication1
Mutagenesisi60E → A: Decreased IgE-binding by more than half of the 24 patients tested. Identified as a major epitope. 1 Publication1
Mutagenesisi62E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi63K → A: Decreased IgE-binding by more than half of the 24 patients tested. Identified as a major epitope. 1 Publication1
Mutagenesisi65K → A: SDecreased IgE-binding by more than half of the 24 patients tested. Identified as a major epitope. 1 Publication1
Mutagenesisi67K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi68E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi71E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi75R → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi76E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi81E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi85R → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi89K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi96K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi99D → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi105R → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi109E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi116E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi120K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi121D → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi124E → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi127K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi128K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi130K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1
Mutagenesisi133K → A: Decreaced IgE-binding by some of the 24 patients tested. 1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
11615, Der f 21.0101
305, Der f 5
5843, Der f 21

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500763949018 – 136Mite allergen Der f 21.0101Sequence analysisAdd BLAST119

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in foregut (stomach), midgut and hindgut. Not expressed in body wall, reproductive system or body cavity.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer.

2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2GM84

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mite group 5 allergen family.Curated

Keywords - Domaini

Coiled coil, Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.970, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020306, Mite_allergen_group-5/21
IPR038455, Mite_allergen_group-5/21_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11642, Blo-t-5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

B2GM84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFIIFCAIV MAVSVSGFIV DVDTEDKWRN AFDHMLMEEF EEKMDQIEHG
60 70 80 90 100
LLMLSEQYKE LEKTKSKELK EQILRELTIA ENYLRGALKF MQQEAKRTDL
110 120 130
NMFERYNFET AVSTIEILVK DLAELAKKVK AVKSDD
Length:136
Mass (Da):15,965
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i278871A9F1E8ACBE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY800349 mRNA Translation: AAX34048.1
KF732965 mRNA Translation: AHC94806.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY800349 mRNA Translation: AAX34048.1
KF732965 mRNA Translation: AHC94806.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YNXX-ray1.49A/B25-135[»]
5YNYX-ray2.30A/B/C/D25-136[»]
SMRiB2GM84
ModBaseiSearch...
PDBe-KBiSearch...

Protein family/group databases

Allergomei11615, Der f 21.0101
305, Der f 5
5843, Der f 21

Family and domain databases

Gene3Di1.20.58.970, 1 hit
InterProiView protein in InterPro
IPR020306, Mite_allergen_group-5/21
IPR038455, Mite_allergen_group-5/21_sf
PfamiView protein in Pfam
PF11642, Blo-t-5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALL21_DERFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2GM84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 17, 2020
Last sequence update: June 10, 2008
Last modified: June 17, 2020
This is version 26 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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