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Entry version 50 (25 Apr 2018)
Sequence version 1 (10 Jun 2008)
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Protein
Submitted name:

Acetyl-CoA carboxylase and Acetyl-CoA carboxylase

Gene

Zr_ACC1 and Zr_HFA1

Organism
Zygosaccharomyces rouxii (Candida mogii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

biotinSAAS annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, BiotinSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Acetyl-CoA carboxylase and Acetyl-CoA carboxylaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zr_ACC1 and Zr_HFA1Imported
ORF Names:Zrou_10p6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZygosaccharomyces rouxii (Candida mogii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4956 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeZygosaccharomyces

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B2G4R2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 567Biotin carboxylationInterPro annotationAdd BLAST510
Domaini216 – 408ATP-graspInterPro annotationAdd BLAST193
Domaini694 – 768Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini1484 – 1820CoA carboxyltransferase N-terminalInterPro annotationAdd BLAST337
Domaini1824 – 2139CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST316

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2035 – 2055Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0368 Eukaryota
COG0439 LUCA
COG0511 LUCA
COG4799 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034733 AcCoA_carboxyl
IPR013537 AcCoA_COase_cen
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
IPR011762 COA_CT_N
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08326 ACC_central, 1 hit
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF01039 Carboxyl_trans, 1 hit
PF02786 CPSase_L_D2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00878 Biotin_carb_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52096 SSF52096, 2 hits
SSF52440 SSF52440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS50989 COA_CT_CTER, 1 hit
PS50980 COA_CT_NTER, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2G4R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEESLFEVS SKVGVEEIAD YAKEHAKLPA SFIGYRTVDK AEESPLKDFV
60 70 80 90 100
RNHGGHTVIS KILIANNGIA AVKEIRSVRK WAYETFGDDR AVQFVAMATP
110 120 130 140 150
EDLEANAEYI RMAEQYVEVP GGTNNNNYAN VDLIVEIAER ADVDAVWAGW
160 170 180 190 200
GHASENPDLP ETLANSKRKI LFIGPPGNAM RSLGDKISST IVAQHAKVPC
210 220 230 240 250
IPWSGTGVDK VRIDYESGLV CVDDEIYKQG CSTSAEDGLE RAKKIGFPVM
260 270 280 290 300
VKASEGGGGK GIRQVHRAED FIPLYNQAAN EIPGSPIFIM KLAGRARHLE
310 320 330 340 350
VQLLADQYGA NVSLFGRDCS VQRRHQKIIE EAPVTIAKPD TFKEMEKAAV
360 370 380 390 400
RLGKLVGYVS AGTVEYLYSH DDDQFYFLEL NPRLQVEHPT TEMVSGVNLP
410 420 430 440 450
AAQLQIAMGI PMHRIRDIRM LYGMHPQQST KIDFEFANEE SSTTQRKPTP
460 470 480 490 500
KGHCTACRIT SEDPNEGFKP SGGSLHELNF RSSSNVWGYF SVGNNGGIHS
510 520 530 540 550
FSDSQFGHIF AFGENRQASR KHMVVALKEL SIRGDFRTTV EYLIKLLETE
560 570 580 590 600
DFEKNTITTG WLDDLISQKM TAEKPDPTLA VICGAATKAF IASEAARQNY
610 620 630 640 650
INSLKKGQVP SKSLLQTMYP VEFIHEGKRY KFTVAKSADD RYTLFINGSK
660 670 680 690 700
CEVRIRKLSD GGLLIAIGGK SHTIYWKDEV SATRLSVDSM TTLLEAEDDP
710 720 730 740 750
TQLRTPSPGK LVKFLVDNGD HIDGGQTYAE VEVMKMQMPL VAQESGVVQL
760 770 780 790 800
LKQPGSTIAA GDIIAILSLD DPSKVKHALP FEGMLPDFGA PIIEGTKPAY
810 820 830 840 850
KFRSLETTLQ NILNGYDNQV IMNPSLQELI KVLRDPQLPY SEWSMQISAL
860 870 880 890 900
HSRLPPKLNE QLSQLVDRSS KRNALFPARQ LNKLLESATK QPDSDPSLTP
910 920 930 940 950
VVEPLLDVTR RYANGLEAHE HSVFVKFLEE YYNVEKLFSS TTEDNVILKL
960 970 980 990 1000
RDEYSDNLEK VVVIVLSHAK VAAKNNLILA ILRHYQPLCK MSSQVASIIS
1010 1020 1030 1040 1050
GPLKHIVELE SKATARVALQ AREILIQGAL PSVKERSEQV EHILKSSVVR
1060 1070 1080 1090 1100
PTYGATNPKR SEPDMEVLKD LIDSNYVVFD VLTPFLSYPD PAVAAAAAQV
1110 1120 1130 1140 1150
YVRHAYRAYT IGEVKVCEGT TTPICKWKFQ MPSAAFTSIP QIKTKFGMNR
1160 1170 1180 1190 1200
AISVSDLTYV ADPENSPLRT GILVSAEHLD DVDDSLAQSL ETIPNTSSSA
1210 1220 1230 1240 1250
AAAGPVPDRS VSSSSLSNVT NVYVQSTDGF ESEADVLSRL REILDSNKQE
1260 1270 1280 1290 1300
LISSAIRRIT FIFGYSDGSY PKYYTFKGPA YEEDKTIRHI EPALAYQLEL
1310 1320 1330 1340 1350
GRMSNFNIKP IFTENRNIHV YEAVGKSTPL DKRFFTRGII RTGRIRDDIS
1360 1370 1380 1390 1400
IQEYLTSEAN RLMSDILDNL EIIDTSNSDL NHIFINFSAV FDVSPEDVEA
1410 1420 1430 1440 1450
AFGGFLQRFG KRLLRLRVAS AEIRIIIKDP ETGAPVPLRA LINNVSGYVV
1460 1470 1480 1490 1500
KTELYTEVKN ANGDWVFKSL GKPGSMHLRP IATPYPVKEW LQPKRYKAHL
1510 1520 1530 1540 1550
MGTTYVYDFP ELFHQALVSQ WQKFSPKTKL NDNFFIANEL IEDENGELTE
1560 1570 1580 1590 1600
VDREPGANTI GMVAFKITAK TPEYPRGRQF VIVSNDITFK VGSFGPQEDE
1610 1620 1630 1640 1650
FFNKVTEYAR KRGIPRIYLS ANSGARIGIA EELVPLFQVA WKDPKDSTKG
1660 1670 1680 1690 1700
FDYLYLTSEG LRELKKYGKD HSVVTERVVE NGEERHLIKA IIGVDEGLGV
1710 1720 1730 1740 1750
ECLRGSGLIA GATSKAYQDI FTITLVTCRS VGIGAYLVRL GQRAIQVEGQ
1760 1770 1780 1790 1800
PIILTGAPAI NKVLGREVYT SNLQLGGTQI MYNNGVSHLT ASDDLAAIEK
1810 1820 1830 1840 1850
ILAWLSYIPA KRNMPVPILE TEDKWDREVE YFPPKEETYD VRWLIAGRDS
1860 1870 1880 1890 1900
PEGFERGLFD KDSFMETLSG WAKGVVVGRA RLGGIPMGVI GVEIRTMQNL
1910 1920 1930 1940 1950
TPADPANPDS TESVSQEAGQ VWYPNSAFKT AQAIRDFNHG EQLPLMILAN
1960 1970 1980 1990 2000
WRGFSGGQRD MYNEVLKYGS FIVDALVDYK QPIMIYIPPT GELRGGSWVV
2010 2020 2030 2040 2050
VDPSINKEHM EMYADKESRA GVLEPAGMVG VKYRREKLLA TMSRLDDTYR
2060 2070 2080 2090 2100
SLKEKLSDAS LSPEEHQEIS KKLSIREKQL LPIYSSISVQ FADLHDRSDR
2110 2120 2130 2140 2150
MLAKGVIRKE LQWVNSRRFF FWRLRRRLNE EYLMRRLDVE LPLASRLEKI
2160 2170 2180 2190 2200
ARLRSWYPAS VDHENDRQVA SWIEENFQLL DEHLKALKLE SFAQSLAKSL
2210 2220 2230
RSDHDNVITG LSEVLKMMSA EDKEKIIKSL K
Length:2,231
Mass (Da):249,440
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B8330D64733C63C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM989989 Genomic DNA Translation: CAQ43571.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM989989 Genomic DNA Translation: CAQ43571.1

3D structure databases

ProteinModelPortaliB2G4R2
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0368 Eukaryota
COG0439 LUCA
COG0511 LUCA
COG4799 LUCA

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR013537 AcCoA_COase_cen
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
IPR011762 COA_CT_N
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF08326 ACC_central, 1 hit
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF01039 Carboxyl_trans, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52096 SSF52096, 2 hits
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS50989 COA_CT_CTER, 1 hit
PS50980 COA_CT_NTER, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2G4R2_ZYGRO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2G4R2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 10, 2008
Last sequence update: June 10, 2008
Last modified: April 25, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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