UniProtKB - B2FTJ1 (B2FTJ1_STRMK)
Protein
Lipoprotein signal peptidase
Gene
lspA
Organism
Stenotrophomonas maltophilia (strain K279a)
Status
Functioni
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotationARBA annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotationARBA annotation EC:3.4.23.36
: lipoprotein biosynthesis (signal peptide cleavage) Pathwayi
This protein is involved in the pathway lipoprotein biosynthesis (signal peptide cleavage), which is part of Protein modification.UniRule annotationView all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (signal peptide cleavage) and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 116 | UniRule annotation | 1 | |
Active sitei | 143 | UniRule annotation | 1 |
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Aspartyl proteaseUniRule annotationARBA annotation, Hydrolase, Protease |
Enzyme and pathway databases
BioCyci | SMAL522373:SMLT_RS06440_1-MONOMER |
UniPathwayi | UPA00665 |
Names & Taxonomyi
Protein namesi | Recommended name: Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)Alternative name(s): Prolipoprotein signal peptidaseUniRule annotation Signal peptidase IIUniRule annotation Short name: SPase IIUniRule annotation |
Gene namesi | Name:lspAUniRule annotationImported Ordered Locus Names:Smlt1341Imported |
Organismi | Stenotrophomonas maltophilia (strain K279a)Imported |
Taxonomic identifieri | 522373 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Stenotrophomonas › Stenotrophomonas maltophilia group › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 72 – 89 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 101 – 119 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 139 – 159 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membraneUniRule annotation, Cell membrane, MembraneFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
eggNOGi | COG0597, Bacteria |
HOGENOMi | CLU_083252_4_0_6 |
OMAi | FIAPKGF |
OrthoDBi | 1575081at2 |
Family and domain databases
HAMAPi | MF_00161, LspA, 1 hit |
InterProi | View protein in InterPro IPR001872, Peptidase_A8 |
PANTHERi | PTHR33695, PTHR33695, 1 hit |
Pfami | View protein in Pfam PF01252, Peptidase_A8, 1 hit |
PRINTSi | PR00781, LIPOSIGPTASE |
TIGRFAMsi | TIGR00077, lspA, 1 hit |
i Sequence
Sequence statusi: Complete.
B2FTJ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPRPHPNA LVWLLLSAAI IGLDQWSKAW VLSSLPEFQP VVVIDGFWNW
60 70 80 90 100
YRTYNTGAAF SFLSDAGGWQ KYFFTALAIA ISGLMAWWLR GTARGNWKAA
110 120 130 140 150
VPYALIIGGA IGNVIDRQVH GHVVDFIQWY VGSYTWPSFN IADSAIVVGA
160 170
IGIALFGLFD GKSAKKADNA NPKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM743169 Genomic DNA Translation: CAQ44888.1 |
RefSeqi | WP_005408564.1, NC_010943.1 |
Genome annotation databases
EnsemblBacteriai | CAQ44888; CAQ44888; Smlt1341 |
KEGGi | sml:Smlt1341 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM743169 Genomic DNA Translation: CAQ44888.1 |
RefSeqi | WP_005408564.1, NC_010943.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 522373.Smlt1341 |
Genome annotation databases
EnsemblBacteriai | CAQ44888; CAQ44888; Smlt1341 |
KEGGi | sml:Smlt1341 |
Phylogenomic databases
eggNOGi | COG0597, Bacteria |
HOGENOMi | CLU_083252_4_0_6 |
OMAi | FIAPKGF |
OrthoDBi | 1575081at2 |
Enzyme and pathway databases
UniPathwayi | UPA00665 |
BioCyci | SMAL522373:SMLT_RS06440_1-MONOMER |
Family and domain databases
HAMAPi | MF_00161, LspA, 1 hit |
InterProi | View protein in InterPro IPR001872, Peptidase_A8 |
PANTHERi | PTHR33695, PTHR33695, 1 hit |
Pfami | View protein in Pfam PF01252, Peptidase_A8, 1 hit |
PRINTSi | PR00781, LIPOSIGPTASE |
TIGRFAMsi | TIGR00077, lspA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2FTJ1_STRMK | |
Accessioni | B2FTJ1Primary (citable) accession number: B2FTJ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 10, 2008 |
Last sequence update: | June 10, 2008 | |
Last modified: | April 7, 2021 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |