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Entry version 28 (05 Dec 2018)
Sequence version 1 (10 Jun 2008)
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Protein

Phyllocladan-16-alpha-ol synthase

Gene

PaDC1

Organism
Phomopsis amygdali (Fusicoccum amygdali)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the synthesis of labdane-related hydrocarbons by catalyzing the conversion of geranylgeranyl diphosphate (GGDP) to phyllocladan-16-alpha-ol in a two step via type B cyclization into a (+)-copalyl diphosphate (+-CDP) intermediate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi667Magnesium 1By similarity1
Metal bindingi667Magnesium 2By similarity1
Metal bindingi671Magnesium 1By similarity1
Metal bindingi671Magnesium 2By similarity1
Metal bindingi872Magnesium 3By similarity1
Metal bindingi876Magnesium 3By similarity1
Metal bindingi880Magnesium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Lyase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:MONOMER-15022

BRENDA Comprehensive Enzyme Information System

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BRENDAi
4.2.3.45 10693

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phyllocladan-16-alpha-ol synthase (EC:4.2.3.45, EC:5.5.1.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PaDC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhomopsis amygdali (Fusicoccum amygdali)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1214568 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeDiaporthalesDiaporthaceaeDiaporthe

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004156661 – 1004Phyllocladan-16-alpha-ol synthaseAdd BLAST1004

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi321 – 324DXDD motif4
Motifi667 – 671DEXXE motif5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DXDD and DEXXE motifs are important for the catalytic activity.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the terpene synthase family.Curated

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K20514

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017057 Ent-kaurene_synthase_fun
IPR008930 Terpenoid_cyclase/PrenylTrfase

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036498 Ent-kaurene_synthase_fungi, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48239 SSF48239, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2DBF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIMDIDDHS RLRDLAVSLI RQAAEGYSPK YGYGSMSCAA YDTAWVSLVA
60 70 80 90 100
KPFNGIKKWL FPQSFKFLLE NQENDGSWGR QTSPVDRILN TAAPLLSLQR
110 120 130 140 150
HAREPLQLHD VCEDGDLDDR IHRATLSLQR QLSDWDIAST AHVGFEIIVP
160 170 180 190 200
ALLNLLAAEG LCFSFKAQDE LMKVNAAKLK RFDPEVLLYG KHKTTLLHSL
210 220 230 240 250
EAFVGIIDFD KVVHHKVGGS FMASPSATAA YLMNASCWDD EAEDYIKNVL
260 270 280 290 300
VNGSGRGHGA VPSAYPSSNF EYSWLLSTLL HAGFTAKDIE CPELCDVAGM
310 320 330 340 350
LENSFIEGQG TIGFARSISS DADDTAKAAF ALNKLGYDVS VNEMVKEFEV
360 370 380 390 400
KNHFQTYPSE RDASLSANCN TLLALLHQKQ VGAYQPQILK CVKFLTRCWW
410 420 430 440 450
NTDGPIRDKW NQSHLYSTML MVQALTEFQA ILDQKGLPYG LNTVEMARVS
460 470 480 490 500
ICLFQGCLRT MLQQCEDGSW SHSREQTAYA VLTLGQARRL STFKHLQSQI
510 520 530 540 550
DSAIDQAATF IRLHSVDLAQ QSLPEFIWTE KVSYTSPLVT EAYCLAALKV
560 570 580 590 600
ATSLVDNPGI VGESLDLGIP SRQRIDKYIW LFHQTPLFRS LPEWQLRASF
610 620 630 640 650
IEGHLFLPIV NEHRLDVFPR KNMDPDDDYI RLIPFTWTAT NNRNFTFASP
660 670 680 690 700
AWLYDMIMVS VVDYQADEFM EAVAGLTFSE DLSMLVGLIQ EVLTPYKTEP
710 720 730 740 750
ASPVTSLIDM SSVQCPRAKL SNIASGDIEE VRTCLRRFAS FFLDHPAVRN
760 770 780 790 800
AQRDDRATAW REVHNYLVAH VRHTQDNMRL NLQEQRRWYV SRNMPYFHWV
810 820 830 840 850
RSNDDIACPI TFGFVTCLVP YLVANPTVER AVIGNESESI VTSSDVSFDS
860 870 880 890 900
VESKYYADDV CRHITNVTRI YNDCGSVVRD ATEKNLNSVN FPEFAVTASG
910 920 930 940 950
SEKQALRAMG EYERACCQAA FQRLEEASLQ TATTEAERAK RRRRLDVWKV
960 970 980 990 1000
FLDTADPYGQ IYVVRDFTAR SVHVRETGIA STAKDVPLVS SSVPLVGGGP

MLVT
Length:1,004
Mass (Da):112,836
Last modified:June 10, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78D85416DEC79A5E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB252834 mRNA Translation: BAG30961.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ag:BAG30961

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB252834 mRNA Translation: BAG30961.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGiag:BAG30961

Phylogenomic databases

KOiK20514

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15022
BRENDAi4.2.3.45 10693

Family and domain databases

InterProiView protein in InterPro
IPR017057 Ent-kaurene_synthase_fun
IPR008930 Terpenoid_cyclase/PrenylTrfase
PIRSFiPIRSF036498 Ent-kaurene_synthase_fungi, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPADC1_PHOAM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2DBF0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: June 10, 2008
Last modified: December 5, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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