UniProtKB - B2CQD6 (B2CQD6_MOUSE)
Protein
Fibulin-1
Gene
Fbln1
Organism
Mus musculus (Mouse)
Status
Functioni
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- peptidase activator activity Source: InterPro
GO - Biological processi
- embryo implantation Source: Ensembl
- extracellular matrix organization Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Fibulin-1UniRule annotationARBA annotation |
Gene namesi | Name:Fbln1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:95487, Fbln1 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Keywords - Cellular componenti
Extracellular matrixUniRule annotation, SecretedPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
PeptideAtlasi | B2CQD6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000006369, Expressed in ear vesicle and 313 other tissues |
ExpressionAtlasi | B2CQD6, baseline and differential |
Interactioni
Subunit structurei
Homomultimerizes and interacts with various extracellular matrix components.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalARBA annotationPhylogenomic databases
HOGENOMi | CLU_004826_1_1_1 |
OrthoDBi | 1174178at2759 |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017048, Fibulin-1 IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 4 hits |
PIRSFi | PIRSF036313, Fibulin-1, 1 hit |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 9 hits SM00179, EGF_CA, 8 hits |
SUPFAMi | SSF57184, SSF57184, 3 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 1 hit PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 3 hits |
i Sequence
Sequence statusi: Complete.
B2CQD6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPVPSRLV PLPLLLLSSL SLLAARANAD ISMEACCTDG NQMANQHRDC
60 70 80 90 100
SLPYTSESKE CRMVQEQCCH NQLEELHCAT GINLASEPEG CASLHSYNSS
110 120 130 140 150
LETIFIKRCC HCCMLGKASL ARDQTCEPIV MISYQCGLVF RACCVKAREN
160 170 180 190 200
SDFVQGNGAD LQDPAKIPDE EDQEDPYLND RCRGGGPCKQ QCRDTGDEVI
210 220 230 240 250
CSCFVGYQLQ SDGVSCEDIN ECITGSHNCR LGESCINTVG SFRCQRDSSC
260 270 280 290 300
GTGYELTEDN NCKDIDECET GIHNCPPDFI CQNTLGSFRC RPKLQCKSGF
310 320 330 340 350
IQDALGNCID INECLSISAP CPVGQTCINT EGSYTCQKNV PNCGRGYHLN
360 370 380 390 400
EEGTRCVDVD ECSPPAEPCG KGHHCLNSPG SFRCECKAGF YFDGISRTCV
410 420 430 440 450
DINECQRYPG RLCGHKCENT PGSFHCSCSA GFRLSVDGRS CEDVNECLNS
460 470 480 490 500
PCSQECANVY GSYQCYCRRG YQLSDVDGVT CEDIDECALP TGGHICSYRC
510 520 530 540 550
INIPGSFQCS CPSSGYRLAP NGRNCQDIDE CVTGIHNCSI NETCFNIQGS
560 570 580 590 600
FRCLSFECPE NYRRSADTFR QEKTDTVRCI KSCRPNDEAC VRDPVHTVSH
610 620 630 640 650
TVISLPTFRE FTRPEEIIFL RAVTPLYPAN QADIIFDITE GNLRDSFDII
660 670 680 690 700
KRYEDGMTVG VVRQVRPIVG PFYAVLKLEM NYVLGGVVSH RNVVNVHIFV
SEYWF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU543224 mRNA Translation: ACB28460.1 |
RefSeqi | NP_034310.2, NM_010180.2 |
Genome annotation databases
GeneIDi | 14114 |
KEGGi | mmu:14114 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU543224 mRNA Translation: ACB28460.1 |
RefSeqi | NP_034310.2, NM_010180.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | B2CQD6 |
Protocols and materials databases
Antibodypediai | 886, 307 antibodies |
Genome annotation databases
GeneIDi | 14114 |
KEGGi | mmu:14114 |
Organism-specific databases
CTDi | 2192 |
MGIi | MGI:95487, Fbln1 |
Phylogenomic databases
HOGENOMi | CLU_004826_1_1_1 |
OrthoDBi | 1174178at2759 |
Miscellaneous databases
BioGRID-ORCSi | 14114, 0 hits in 17 CRISPR screens |
ChiTaRSi | Fbln1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006369, Expressed in ear vesicle and 313 other tissues |
ExpressionAtlasi | B2CQD6, baseline and differential |
Family and domain databases
CDDi | cd00017, ANATO, 2 hits |
InterProi | View protein in InterPro IPR000020, Anaphylatoxin/fibulin IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR017048, Fibulin-1 IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF12662, cEGF, 3 hits PF07645, EGF_CA, 4 hits |
PIRSFi | PIRSF036313, Fibulin-1, 1 hit |
SMARTi | View protein in SMART SM00104, ANATO, 3 hits SM00181, EGF, 9 hits SM00179, EGF_CA, 8 hits |
SUPFAMi | SSF57184, SSF57184, 3 hits |
PROSITEi | View protein in PROSITE PS01177, ANAPHYLATOXIN_1, 1 hit PS01178, ANAPHYLATOXIN_2, 3 hits PS00010, ASX_HYDROXYL, 4 hits PS01186, EGF_2, 3 hits PS50026, EGF_3, 4 hits PS01187, EGF_CA, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2CQD6_MOUSE | |
Accessioni | B2CQD6Primary (citable) accession number: B2CQD6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 10, 2021 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |