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Entry version 79 (18 Sep 2019)
Sequence version 1 (20 May 2008)
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Protein
Submitted name:

Hemagglutinin/protease regulatory protein

Gene

hapR

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi39 – 58H-T-H motifPROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, Hydrolase, ProteaseImported
Biological processTranscription, Transcription regulationSAAS annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001683415:G1EY1-2348-MONOMER
GCF_001887395:G1FEI-631-MONOMER
GCF_001887415:G1FEK-1878-MONOMER
GCF_001887455:G1FEM-624-MONOMER
GCF_001887515:G1FEN-595-MONOMER
GCF_001887635:G1FES-2323-MONOMER
GCF_001887655:G1FEU-689-MONOMER
VCHO345073:G1GU4-643-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Hemagglutinin/protease regulatory proteinImported
Submitted name:
LuxR family transcriptional regulatorImported
Submitted name:
TetR/AcrR family transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hapRImported
ORF Names:C9J66_10080Imported, EN12_02415Imported, ERS013138_01392Imported, ERS013140_02369Imported, ERS013173_01523Imported, ERS013186_00946Imported, ERS013193_02550Imported, ERS013198_01284Imported, ERS013202_02486Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio choleraeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri666 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248087 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000036184 Componenti: Chromosome 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi199InterchainCombined sources

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 76HTH tetR-typeInterPro annotationAdd BLAST61

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410630P Bacteria
ENOG410XUF9 LUCA

KEGG Orthology (KO)

More...
KOi
K10913

Database of Orthologous Groups

More...
OrthoDBi
1437290at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00440 TetR_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00455 HTHTETR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50977 HTH_TETR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2CKP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDASIEKRPR TRLSPQKRKL QLMEIALEVF AKRGIGRGGH ADIAEIAQVS
60 70 80 90 100
VATVFNYFPT REDLVDDVLN FVVRQYSNFL TDHIDLDLDV KTNLQTLCKE
110 120 130 140 150
MVKLAMTDCH WLKVWFEWSA STRDEVWPLF VSTNRTNQLL IRNMFMKAME
160 170 180 190 200
RGELCEKHDV DNMASLFHGI FYSIFLQVNR LGEQEAVYKL ADSYLNMLCI

YKN
Length:203
Mass (Da):23,692
Last modified:May 20, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35679B4297F29223
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU523708 Genomic DNA Translation: ACB30338.1
EU523709 Genomic DNA Translation: ACB30339.1
EU523710 Genomic DNA Translation: ACB30340.1
EU523724 Genomic DNA Translation: ACB30353.1
EU523726 Genomic DNA Translation: ACB30354.1
CP007653 Genomic DNA Translation: AKO74108.1
CWPD01000006 Genomic DNA Translation: CSA66282.1
CWPO01000003 Genomic DNA Translation: CSB28624.1
CWQA01000005 Genomic DNA Translation: CSB75272.1
CWPV01000012 Genomic DNA Translation: CSC25973.1
CWQG01000010 Genomic DNA Translation: CSC26025.1
CWRC01000021 Genomic DNA Translation: CSC67756.1
CWRE01000074 Genomic DNA Translation: CSD06953.1
PYRF01000008 Genomic DNA Translation: PYC82041.1

NCBI Reference Sequences

More...
RefSeqi
WP_000340098.1, NZ_UWOZ01000006.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AKO74108; AKO74108; EN12_02415
CSA66282; CSA66282; ERS013173_01523
CSB28624; CSB28624; ERS013186_00946
CSB75272; CSB75272; ERS013198_01284
CSC25973; CSC25973; ERS013193_02550
CSC26025; CSC26025; ERS013202_02486
CSC67756; CSC67756; ERS013138_01392
CSD06953; CSD06953; ERS013140_02369

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vcq:EN18_19905

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|666.1967.peg.2649

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU523708 Genomic DNA Translation: ACB30338.1
EU523709 Genomic DNA Translation: ACB30339.1
EU523710 Genomic DNA Translation: ACB30340.1
EU523724 Genomic DNA Translation: ACB30353.1
EU523726 Genomic DNA Translation: ACB30354.1
CP007653 Genomic DNA Translation: AKO74108.1
CWPD01000006 Genomic DNA Translation: CSA66282.1
CWPO01000003 Genomic DNA Translation: CSB28624.1
CWQA01000005 Genomic DNA Translation: CSB75272.1
CWPV01000012 Genomic DNA Translation: CSC25973.1
CWQG01000010 Genomic DNA Translation: CSC26025.1
CWRC01000021 Genomic DNA Translation: CSC67756.1
CWRE01000074 Genomic DNA Translation: CSD06953.1
PYRF01000008 Genomic DNA Translation: PYC82041.1
RefSeqiWP_000340098.1, NZ_UWOZ01000006.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6D7RX-ray2.10A/B1-203[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiAKO74108; AKO74108; EN12_02415
CSA66282; CSA66282; ERS013173_01523
CSB28624; CSB28624; ERS013186_00946
CSB75272; CSB75272; ERS013198_01284
CSC25973; CSC25973; ERS013193_02550
CSC26025; CSC26025; ERS013202_02486
CSC67756; CSC67756; ERS013138_01392
CSD06953; CSD06953; ERS013140_02369
KEGGivcq:EN18_19905
PATRICifig|666.1967.peg.2649

Phylogenomic databases

eggNOGiENOG410630P Bacteria
ENOG410XUF9 LUCA
KOiK10913
OrthoDBi1437290at2

Enzyme and pathway databases

BioCyciGCF_001683415:G1EY1-2348-MONOMER
GCF_001887395:G1FEI-631-MONOMER
GCF_001887415:G1FEK-1878-MONOMER
GCF_001887455:G1FEM-624-MONOMER
GCF_001887515:G1FEN-595-MONOMER
GCF_001887635:G1FES-2323-MONOMER
GCF_001887655:G1FEU-689-MONOMER
VCHO345073:G1GU4-643-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
PRINTSiPR00455 HTHTETR
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS50977 HTH_TETR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2CKP3_VIBCL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2CKP3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 18, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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Main funding by: National Institutes of Health

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