Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase

Gene

phnN

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).By similarity

Catalytic activityi

ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase (phnN), Ribose 1,5-bisphosphate phosphokinase PhnN (phnN)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTAI977880:RALTA_RS17480-MONOMER
UniPathwayiUPA00087; UER00175

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylase
Including the following 2 domains:
Ribose 1,5-bisphosphate phosphokinase PhnN (EC:2.7.4.23)
Alternative name(s):
Ribose 1,5-bisphosphokinase
Putative thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:phnN
Ordered Locus Names:RALTA_B0356
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004127791 – 601Bifunctional ribose 1,5-bisphosphokinase-thymidine phosphorylaseAdd BLAST601

Proteomic databases

PRIDEiB2AIF3

Interactioni

Protein-protein interaction databases

STRINGi977880.RALTA_B0356

Structurei

3D structure databases

ProteinModelPortaliB2AIF3
SMRiB2AIF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the ribose 1,5-bisphosphokinase family.Curated
In the C-terminal section; belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CMW Bacteria
COG0213 LUCA
COG3709 LUCA
HOGENOMiHOG000252767
KOiK00758
OMAiVHSIGGV

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_00836 PhnN, 1 hit
MF_00703 Thymid_phosp_2, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR000312 Glycosyl_Trfase_fam3
IPR035902 Nuc_phospho_transferase
IPR027417 P-loop_NTPase
IPR012699 PhnN
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR028579 Thym_Pase_Put
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00941 PYNP_C, 1 hit
SUPFAMiSSF52418 SSF52418, 1 hit
SSF52540 SSF52540, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02322 phosphon_PhnN, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

B2AIF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASGTFFFV VGPSGAGKDA LMDGARAALD DNYVFARRVI TRPEGAVGEA
60 70 80 90 100
HEAVSEAEFA RRQRSGEFLV TWDAHDLRYG LPCSLMSELE RGRHVVANGS
110 120 130 140 150
RAVIAELAQR LPRFVVVLVT APQDVLARRI AARGRESGEQ IARRVARTGA
160 170 180 190 200
ALPPEVRCLT VLNDSTLEVG RARFVEALRH GTRVASDGAP ASRTNLMAKL
210 220 230 240 250
RGEPLDQAAY VAVLQDAMAG RYTEAELTEF LVAATRSLDD QEVVALARAR
260 270 280 290 300
TVFTPRIKWD EPIVVDKHSI GGVPGSRITL IVVPIVAAYG LAMPKTSSRA
310 320 330 340 350
ITSAAGTADA METVARVDLA HDDVRRCVAQ ARACIAWNGR LNHSVVDDVM
360 370 380 390 400
NAITRPLRLD SRRWAVASIL SKKYTAGATH VIVDLPYGPQ TKLATRADAE
410 420 430 440 450
ALGAMFEHVG KGLGLHVRAL VTDGSRPIGR GIGPALEVRD VRQVLANDPC
460 470 480 490 500
APADLREKAL RFAGEIIAFD ARVGSPAEGL RIATALLSEG KAKAAFDRIA
510 520 530 540 550
ATQGARPEPV APGAHTCVVS ATMQGRVAAI DGLRISGVAR AAGAPRELGA
560 570 580 590 600
GVDLLCTIGA KVESGQPLYR IHAGSDAALA AAAALARAGG ECSEAVRIDP

D
Length:601
Mass (Da):63,485
Last modified:May 20, 2008 - v1
Checksum:i2C4BD4BA05B4E774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633750 Genomic DNA Translation: CAP63552.1
RefSeqiWP_012355206.1, NC_010530.1

Genome annotation databases

EnsemblBacteriaiCAP63552; CAP63552; RALTA_B0356
GeneIDi29765621
KEGGicti:RALTA_B0356

Similar proteinsi

Entry informationi

Entry nameiRBKTP_CUPTR
AccessioniPrimary (citable) accession number: B2AIF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: May 20, 2008
Last modified: July 18, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health