Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Binding sitei196SubstrateUniRule annotation1
Binding sitei226SubstrateUniRule annotation1
Binding sitei230SubstrateUniRule annotation1
Binding sitei231NADUniRule annotation1
Binding sitei283NADUniRule annotation1
Binding sitei318NADUniRule annotation1
Binding sitei384NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 199NADUniRule annotation3
Nucleotide bindingi260 – 265NADUniRule annotation6
Nucleotide bindingi339 – 341NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciCTAI977880:RALTA_RS00930-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:RALTA_A0188
OrganismiCupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424))
Taxonomic identifieri977880 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000001692 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001292801 – 472AdenosylhomocysteinaseAdd BLAST472

Proteomic databases

PRIDEiB2AGG2

Interactioni

Protein-protein interaction databases

STRINGi977880.RALTA_A0188

Structurei

3D structure databases

ProteinModelPortaliB2AGG2
SMRiB2AGG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2AGG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVTDLKQD YLVADINLAG WGRKEIAIAE TEMPGLMAIR DEFAAAQPLK
60 70 80 90 100
GARIAGSLHM TIQTAVLIET LKALGADVRW ASCNIFSTQD HAAAAIAAGG
110 120 130 140 150
TPVFAFKGES LKEYWDFTHR IFDWADGGTP NMILDDGGDA TLLLHLGARA
160 170 180 190 200
EKDQSVIANP GSEEETFLFA AIKEKLAKDP SWYSRNLAAI RGVTEETTTG
210 220 230 240 250
VHRLYQMAQK GELRFPAINV NDSVTKSKFD NLYGCRESLV DGIKRATDVM
260 270 280 290 300
IAGKIAVVAG YGDVGKGSAQ ALRALSAQVW VTEIDPICAL QAAMEGYRVV
310 320 330 340 350
TMDYAAEHGD IFVTCTGNYH VITHEHMAKM KDQAIVCNIG HFDNEIDIAS
360 370 380 390 400
IEKYEWDEIK PQVDHVKFPD GKKLIILAKG RLVNLGCATG HPSYVMSSSF
410 420 430 440 450
ANQTIAQIEL WQERDSGKYP VGVYTLPKHL DEKVARLQLR KLNAQLTELT
460 470
DQQAAYIGVK KEGPYKADHY RY
Length:472
Mass (Da):51,913
Last modified:May 20, 2008 - v1
Checksum:i21D807EC34110B95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633749 Genomic DNA Translation: CAP62861.1
RefSeqiWP_012351529.1, NC_010528.1

Genome annotation databases

EnsemblBacteriaiCAP62861; CAP62861; RALTA_A0188
GeneIDi29760792
KEGGicti:RALTA_A0188

Similar proteinsi

Entry informationi

Entry nameiSAHH_CUPTR
AccessioniPrimary (citable) accession number: B2AGG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: July 18, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health